Systemic therapy agents
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Prostate cancer is dependent on androgen receptor (AR) signaling, and androgen deprivation therapy (ADT) has proven effective in targeting prostate cancer. However, castration-resistant prostate cancer (CRPC) eventually emerges. AR signaling inhibitors (ARSI) have been also used, but resistance to these agents develops due to genetic AR alterations and epigenetic dysregulation.
12p vishanshan 27-06-2024 1 1 Download
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Ebook "Breast cancer chemosensitivity" include in-depth discussions on multidrug resistance by P-glycoprotein and the multidrug resistance protein family, resistance to therapeutic agent-induced apoptosis, cell cycle deregulation, deregulation of DNA repair, loss of tumor suppressor genes, integrin-mediated adhesion, insulin-like growth factors, epidermal growth factor, and ErbB2 in modulating breast cancer response to systemic therapy, especially, certain chemotherapeutic agents.
187p tracanhphuonghoa1007 22-04-2024 3 1 Download
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Part 1 book "Small animal clinical pharmacology and therapeutics" includes content: Principles of clinical pharmacology, clinical pharmacokinetics, adverse drug reactions, the pharmacology of the autonomic nervous system, anesthetic agents, behavior-modifying drugs, antibacterial drugs, systemic antifungal therapy, antiparasitic drugs,.... and other contents.
484p muasambanhan03 25-12-2023 3 1 Download
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Part 1 book "Small animal clinical pharmacology" includes content: Principles of clinical pharmacology, clinical pharmacokinetics, adverse drug reactions, the pharmacology of the autonomic nervous system, anesthetic agents, sedatives, behavior modifying drugs, antibacterial drugs, systemic antifungal therapy, antiparasitic drugs, glucocorticosteroids and antihistamines, immunomodulatory therapy.
291p muasambanhan03 25-12-2023 4 1 Download
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Central nervous system (CNS) metastases including brain metastases (BM) and leptomeningeal metastases (LM) are frequent in epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC), and are correlated with poor outcomes.
11p vischultz 20-10-2023 2 1 Download
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Part 2 book "Handbook of veterinary pharmacology" includes content: Respiratory pharmacology, drugs acting on the gastrointestinal tract, endocrine pharmacology, topical dermatology therapy, ocular pharmacology, antimicrobial drugs, antiparasitic agents, antineoplastic drugs, fluid and blood therapy, drug interactions and adverse drug reactions... and other contents.
330p oursky05 20-09-2023 4 2 Download
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High-grade and recurrent meningiomas are often treatment resistant and pose a therapeutic challenge after surgical and radiation therapy (RT) failure. Temozolomide (TMZ) is a DNA alkylating agent that appears to have a radiosensitizing effect when used in combination with RT and may be worthwhile in meningioma treatment.
6p vikolindagrabar 27-07-2022 6 2 Download
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This paper provides an overview of systematic reviews that assessed the effectiveness of SOT compared with the best supportive care (BSC) or placebo in patients with advanced esophageal or gastric cancers in an end-of-life context.
18p vimahuateng 26-11-2021 7 1 Download
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Re-excision rates following breast conserving surgery (BCS) remain as high as ~ 35%, with positive margins detected during follow-up histopathology. Additional breast cancer resection surgery is not only taxing on the patient and health care system, but also delays adjuvant therapies, increasing morbidity and reducing the likelihood of a positive outcome.
9p vianrose2711 27-04-2021 7 1 Download
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Chemo-radiotherapy and systemic therapies have proven satisfactory outcomes as standard treatments for various thoracic malignancies; however, adverse pulmonary efects, like pneumonitis, can be life-threatening. Pneumonitis is caused by direct cytotoxic efect, oxidative stress, and immune-mediated injury.
12p vimichigan2711 26-03-2021 12 2 Download
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At present, there are no widely accepted criteria for the use of radiofrequency ablation (RFA) for the treatment of colorectal liver metastases (CLM) in the context of effective modern-agent therapies. We aimed to define selection criteria for patients with liver-limited CLM who may benefit from adding RFA to systemic therapy with respect to long-term disease control.
11p virose2711 22-09-2020 12 4 Download
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Preclinical research indicate that vascular disrupting agent (VDA) treatment induces extensive tumor death but also a systemic mobilization of bone marrow derived cells including endothelial progenitor cells (EPC) leading to revascularization and renewed growth within the residual tumor.
11p vimale2711 25-08-2020 14 2 Download
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The rapidly expanding arsenal of chemotherapeutic agents approved in the past 5 years represents significant progress in the field. However, this poses a challenge for oncologists to choose which drug or combination of drugs is best for any individual. Because only a fraction of patients respond to any drug, efforts have been made to devise strategies to personalize care.
11p vimale2711 25-08-2020 7 1 Download
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The prognosis of patients with gastrointestinal stromal tumor (GIST) after the failure of standard therapies is poor with supportive care alone. Guidelines recommend clinical trials, and patients with good performance status following standard therapies are often eligible for phase I clinical trials of investigational agents; however, there are no detailed reports on the clinical outcomes of GIST patients enrolled in these trials.
9p vimale2711 25-08-2020 11 2 Download
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Spinal cord astrocytoma is a rare neoplasm, and patients usually recur within months after surgery. There is currently a lack of consensus regarding post-operative treatment. Clinical data on the activity of systemic treatment like chemoradiotherapy and anti-angiogenic agents also remained scant.
6p vidhaka2711 31-07-2020 11 2 Download
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The use of oral systemic anticancer therapies (SACT) has increased and led to improved cancer survival outcomes, particularly with the introduction of small molecule targeted agents and immunomodulators.
15p viputrajaya2711 22-06-2020 13 0 Download
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Blood stream infection is one of the major causes of mortality and morbidity of pediatric patients. Early detection of etiological agents and initiation of appropriate antibiotic therapy is utmost important for better prognosis and survival of such patients. BACTEC 9050 culture method is more sensitive than conventional blood culture method for detection of infection in respect to culture positivity rate and early detection.
6p nguathienthan5 04-06-2020 15 1 Download
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: Patients diagnosed with metastatic castration-refractory prostate cancer (mCRPC) rely on a limited number of therapeutic agents resulting in a median survival of 2–3 years. A subgroup of those patients with mCRPC presents with oligoprogressive disease.
7p viorochimaru2711 01-06-2020 5 1 Download
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Antibiotics play an indispensable role in animal health, welfare and production management. They find their place is as sub-therapeutic, prophylactic, metaphylactic and therapeutic agents for use in livestock sector. However, the possibility for transfer of antibiotics resistance genes among livestock through food chain and environment is probably a direct threat to public health. This review focuses on the prudential use of antibiotics and advocating various practices which can potentially minimize the usage of antibiotics in livestock production system.
18p kethamoi2 14-12-2019 29 0 Download
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Thyroid cancer is the second most common cancer diagnosed during pregnancy after breast cancer. The goal of management is to control malignancy and prevent maternal and fetal complications as a result of maternal hypothyroidism. The role of female sex hormones as an etiologic factor was investigated, with no clear association. Pregnancy can cause an increase in size of a previously existed thyroid nodule through the structural similarity between TSH and BHCG, and the normally expressed estrogen receptors on thyroid gland cells.
6p kequaidan1 16-11-2019 15 0 Download