Systemic toxicity

Nervous system toxicity (NST) is one of the most frequent and dangerous side effects of chimeric antigen receptor T-cell (CAR-T) therapy, which is an effective treatment for related tumors in most relapsed/refractory (r/r) hematologic malignancies. Current clinical trial data do not fully reflect the real-world situation. Therefore, this study evaluated the NST of CAR-T therapy using the FDA Adverse Event Reporting System (FAERS).

11p vishanshan 27-06-2024 2 1   Download

Diffuse midline glioma (DMG), H3 K27M-mutant is a type of diffuse high-grade glioma that occurs in the brain midline carrying an extremely poor prognosis under the best efforts of surgery, radiation, and other therapies. For better therapy, we explored the efficacy and toxicity of a novel therapy that combines apatinib and temozolomide in DMG.

12p vishanshan 27-06-2024 2 1   Download

The prognosis of patients with Relapsed/Refractory Osteosarcoma (R/R OS) remains dismal without an agreement on systemic therapy. The use of High-Dose Ifosfamide (14 g/sqm) with an external pump in outpatient setting (14-IFO) in R/R OS patients is limited. This study represents the first retrospective cohort analysis focused on evaluating the activity and toxicity of 14-IFO in this setting.

12p vikoch 27-06-2024 1 1   Download

Toxic metals in water systems pose a global health risk. Thus, multifunctional water monitoring and treatment materials are indispensable. Nickel ions, a frequent heavy metal pollutant, affect ecosystem function. This study investigates the utilization of Al2O3@g-C3N4 (AlCN) nanosorbent for adsorbing Ni (II) ions from aqueous solutions.

9p visergeyne 18-06-2024 0 0   Download

The GLP regulations have developed from rules on how to exactly document the planning, conduct and reporting of toxicity studies to a quality system for the management of a multitude of study types, from the simple determination of a physical/chemical parameter to the most complex field tests or ecotoxicology studies. At the same time the term "Good Laboratory Practice" has become somewhat of a slogan with the aim to characterise any reliably conducted laboratory work.

432p vimeyers 29-05-2024 5 2   Download

Ebook "Water treatment technologies for the removal of high-toxicity pollutants" process requires interdisciplinary approach; it is critically important to stimulate interactions between medical doctors, chemists, physicist, materials scientists, engineers and policy makers, which are already experienced in their specific areas. It is also our ethical obligation to preserve existing water resources and existing eco systems enhancing their biodiversity.

338p giangdongdinh 28-05-2024 1 1   Download

Ebook "Systems for drug delivery: Safety, animal, and microbial polysaccharides" details current developments in all natural polymers, with a focus on animal and microbial polysaccharides. The book examines, compares, and contrasts the efficiency of plant and algae based natural polymers in inducing immune reactions. Additionally, the book details the safety and toxicity profiles with respective regulations.

205p tracanhphuonghoa1007 22-04-2024 8 2   Download

Ebook "Nanotechnologies in food and agriculture" presents a comprehensive overview of new and emerging nanotechnologies. It includes aspects of nanoparticle monitoring, toxicity, and public perception, and covers applications that address both crop growing and treatment of agricultural wastewater. Topics include nanoagrochemicals (nanofertilizers, -pesticides, -herbicides), nanobiosensors, and nanotechnologies for food processing, packaging, and storage, crop improvement and plant disease control. The group of expert authors is led by an experienced team of editors.

352p tudohanhtau1006 29-03-2024 2 1   Download

Ebook "Major impacts and plate tectonics: A model for the Phanerozoic evolution of the Earth’s lithosphere" presents evidence to show that impacts can cause significant and dramatic changes in track, which cannot be explained by current theories of plate tectonics. The book also demonstrates that such major impact events often coincide with the development of continental flood basalts and oceanic plateau basalts and frequently coincide with major stratigraphic stage boundaries and toxicity, which in turn can be associated with periods of extinction.

358p duongthandue0501 28-02-2024 2 1   Download

Part 2 book "Neurology board review - An illustrated study guide" includes content: Neurocutaneous syndromes; inflammatory and demyelinating disorders of the central nervous system; neurology of infectious diseases; neoplasms of the nervous system and related topics; toxic and metabolic disorders of the nervous system; headache; neurology of sleep disorders; disorders of the spinal cord and anterior horn cells; disorders of the peripheral nervous system; disorders of the autonomicnervous system; disorders of neuromusculartransmission; disorders of muscle; inborn errors of metabolism.

483p muasambanhan07 20-02-2024 4 0   Download

Ebook Ecotoxicology: A comprehensive treatment - Part 1 includes content: The hierarchical science of ecotoxicology, the organismal ecotoxicology context, biochemistry of toxicants, cells and tissues, organs and organ systems, bioaccumulation,… and other contents. Invite you to consult the details.

501p longtimenosee03 01-02-2024 4 0   Download

Ebook A textbook of modern toxicology (Fourth edition): Part 2 includes content: Hepatotoxicity, toxicology of the nervous system, reproductive system, endocrine toxicology, respiratory toxicology, immune system, toxicity testing, forensic and clinical toxicology,… and other contents. Invite you to refer.

374p longtimenosee03 01-02-2024 2 0   Download

Part 2 book "Nutraceuticals in veterinary medicine" includes content: Nutraceuticals in organ and system disorders; nutraceuticals in specific animal species; safety and toxicity evaluation of nutraceuticals and functional foods; newer trends in nutraceutical research and product development; regulatory aspects and country specific requirements for nutraceuticals.

380p muasambanhan06 03-02-2024 14 1   Download

Ebook "Infectious diseases and nanomedicine I: First International Conference (ICIDN-2012), Dec. 15–18, 2012, Kathmandu, Nepal" addresses the interdisciplinary scientific approach for the systemic understanding of connections between major human diseases and their treatment regime by applying the tools and techniques of nanotechnology. It also highlights the interdisciplinary collaborative researches for innovation in Biomedical Sciences.

127p nhanphanguyet 28-01-2024 4 2   Download

Part 2 book "Goat medicine and surgery" includes content: Nervous system disorders, musculoskeletal disease including foot disorders, urinary tract disease, skin diseases, mammary gland disorders, sensory organ disease, metabolic disorders, trace element and vitamin disorders, poisoning and toxicities, exotic and emerging diseases, anaesthesia, fluid therapy, euthanasia, post mortem examination and sampling.

176p muasambanhan04 07-01-2024 5 1   Download

Part 1 book "Avian nutrition, poultry - Ratite and tamed birds" includes content: Introduction, feeds of poultry, nutrients, function of nutrients, feed additives, anti nutritional factors in poultry feed ingredients, harmful and toxic fungi in foods (mycotoxicosis and mycoses), physical quality assay of feeds, the digestive system, digestion, absorption and metabolism, poultry feed processing technology.

196p muasambanhan04 14-01-2024 3 2   Download

Part 1 book "Food safety - Basic concepts, recent issues, and future challenges" includes content: Food safety systems, regulations for food toxins, safe food production with minimum and judicious use of pesticides, toxic elements.

13p muasambanhan03 02-01-2024 4 2   Download

Ebook "Neural cell biology" delineates how systems biology, pharmacogenomic, and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. The text　reviews and　discusses approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development.

348p lucchinguyen 28-12-2023 7 2   Download

Ebook "Modelling the toxicity of nanoparticles" provides practical guidelines on how to develop and validate quantitative nanostructure-toxicity relationship (QNTR) models, which are ideal for rapidly exploring the effects of a large number of variables in complex scenarios.

360p lucchinguyen 28-12-2023 7 2   Download

Methotrexate (MTX) is a chemotherapy and immunosuppressive agent widely used to treat cancer, autoimmune diseases in children and adult patients, and ectopic pregnancy. However, MTX is highly toxic to the liver, kidney, and nervous system. This study aimed to quantify the concentration of MTX in human plasma using high-performance liquid chromatography (HPLC).

6p vikissinger 21-12-2023 1 1   Download