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Systems biology despite
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Despite the known association between healthy lifestyles and reduced risk of breast cancer, it remains unclear whether systemic inflammation, as a consequence of unhealthy lifestyles, may mediate the association.
9p
vikoch
27-06-2024
2
1
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Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. However, despite extensive clinical and genomic studies, the molecular basis of AD development and progression remains elusive.
21p
vioraclene
31-03-2024
2
2
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Ebook "Ultrafast phenomena in molecular sciences: Femtosecond physics and chemistry" presents the latest developments in Femtosecond Chemistry and Physics for the study of ultrafast photo-induced molecular processes. Molecular systems, from the simplest H2 molecule to polymers or biological macromolecules, constitute central objects of interest for Physics, Chemistry and Biology, and despite the broad range of phenomena that they exhibit, they share some common behaviors.
298p
nhanphanguyet
28-01-2024
15
2
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Radiotherapy (RT) is the standard of care for most advanced head and neck squamous cell carcinoma (HNSCC) and results in an unfavorable 5-year overall survival of 40%. Despite strong biological rationale, combining RT with immune checkpoint inhibitors does not result in a survival benefit.
8p
visharma
20-10-2023
3
2
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The lymphatic and the blood vasculature are closely related systems that collaborate to ensure the organism’s physiological function. Despite their common developmental origin, they present distinct functional fates in adulthood that rely on robust lineage-specific regulatory programs.
10p
vihagrid
30-01-2023
4
3
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Promoter-proximal pausing of RNA polymerase II (RNAPII) is a critical step for the precise regulation of gene expression. Despite the apparent close relationship between promoter-proximal pausing and nucleosome, the role of chromatin remodeler governing this step has mainly remained elusive.
29p
viarchimedes
26-01-2022
7
0
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Gene regulatory network inference remains a challenging problem in systems biology despite the numerous approaches that have been proposed. When substantial knowledge on a gene regulatory network is already available, supervised network inference is appropriate.
14p
viwyoming2711
16-12-2020
10
1
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Optimization is the key to solving many problems in computational biology. Global optimization methods, which provide a robust methodology, and metaheuristics in particular have proven to be the most efficient methods for many applications. Despite their utility, there is a limited availability of metaheuristic tools.
9p
vikentucky2711
26-11-2020
6
0
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High quality functional annotation is essential for understanding the phenotypic consequences encoded in a genome. Despite improvements in bioinformatics methods, millions of sequences in databanks are not assigned reliable functions.
12p
viconnecticut2711
28-10-2020
15
1
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Isolation and functional characterization of a high affinity urea transporter from roots of Zea mays
Despite its extensive use as a nitrogen fertilizer, the role of urea as a directly accessible nitrogen source for crop plants is still poorly understood. So far, the physiological and molecular aspects of urea acquisition have been investigated only in few plant species highlighting the importance of a high-affinity transport system.
15p
viminato2711
22-05-2020
11
1
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Algal biofuel has a potential for reducing dependence on fossil fuel while curbing CO2 emissions. Despite these potential benefits, a scalable, sustainable, and commercially viable system has not yet been developed.
9p
viharuno2711
24-04-2020
8
1
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The above procedure for testing the statistical significance of performance differences between types can also be used to explore the potential benefits of combining the two typologies. It might be argued, for example, that despite (possible) structural similarities PR regions are, prima facie, very different, from Intermediate ones, and that the Structural Typology should therefore be applied to the Intermediate and PR regions, or to each of the D-P types separately.
172p
nhacsihuytuan
13-04-2013
51
5
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Temperature has a strong influence on most individual biochemical reac-tions. Despite this, many organisms have the remarkable ability to keep certain physiological fluxes approximately constant over an extended tem-perature range. In this study, we show how temperature compensation can be considered as a pathway phenomenon rather than the result of a single-enzyme property.
11p
galaxyss3
21-03-2013
32
2
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Multiple proteases of the same family are quite often present in the same species in biological systems. These multiple proteases, despite having high homology in their primary and tertiary structures, show deviations in prop-erties such as stability, activity, and specificity.
14p
media19
05-03-2013
30
2
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The repressor protein and cognate operator DNA of any temperateStaph-ylococcus aureusphage have not been investigated in depth, despite having the potential to enrich the molecular biology of the staphylococcal system. In the present study, using the extremely pure repressor of temperate Staphylococcus aureusphage/11 (CI)
11p
viettel02
22-02-2013
36
2
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Despite the aberrant expression of cholinesterases in tumours, the question of their possible contribution to tumorigenesis remains unsolved. The identifica-tion in kidney of a cholinergic system has paved the way to functional studies, but details on renal cholinesterases are still lacking. To fill the gap and to determine whether cholinesterases are abnormally expressed in renal tumours, paired pieces of normal kidney and renal cell carcinomas (RCCs) were compared for cholinesterase activity and mRNA levels....
11p
viettel02
19-02-2013
31
1
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Peer-to-peer systems and applications are distributed systems without any centralized control or hierarchical organization, in which each node runs software with equivalent functionality. A review of the features of recent peer-to-peer applications yields a long list: redundant storage, permanence, selection of nearby servers, anonymity, search, authentication, and hierarchical naming. Despite this rich set of features, the core operation in most peer-to-peer systems is efficient location of data items.
14p
doiroimavanchuadc
06-02-2013
46
3
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Despite the many perks of renewable energy systems, there are several barriers to market development. The first and foremost of these barriers is cost. Most small-scale renewable energy technologies are substantially more expensive on a dollars-per-watt basis than conventional sources. Part of this cost inequity can be attributed to the array of generous subsidies for fossil and nuclear power. (These subsidies are so long-standing and well entrenched in the marketplace that they are hardly considered subsidies any longer.
362p
mebachano
01-02-2013
37
6
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There has been a great deal of progress since the original breast guidance was published, so much so that it may seem to some that implementation of that guidance is largely achieved, that modern multidisciplinary breast cancer care is ‘a done deal’. But the challenges of rising numbers of new referrals, the need to respond within tight time-scales, and advances in diagnosis and treatment mean that teams must be very well organised and well supported to succeed. Despite obvious progress, breast teams do not all work optimally.
0p
taisaokhongthedung
07-01-2013
48
1
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Creating institutions to meet the challenge of sustainability is arguably the most important task confronting society; it is also dauntingly complex. Ecological, economic, and social elements all play a role, but despite ongoing efforts, researchers have yet to succeed in integrating the various disciplines in a way that gives adequate representation to the insights of each.Panarchy, a term devised to describe evolving hierarchical systems with multiple interrelated elements, offers an important new framework for understanding and resolving this dilemma.
650p
greengrass304
14-09-2012
59
14
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