Tablet formulation
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The dissolution and the release kinetics of the active ingredient of the reference tablet Tylenol 8 Hour 650 mg were surveyed in order to formulate the paracetamol 650mg prolonged release tablet and there was an in vitro equivalent evaluation between the prepared paracetamol 650mg prolonged release tablet and the reference tablet Tylenol 8 Hour 650 mg.
9p vispacex 16-11-2023 4 2 Download
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To design and optimize the formula of amlodipine 5 mg immediate-release film-coated tablets and formulate a film coating for amlodipine 5 mg immediate-release film-coated tablets. Methods: The immediate-release tablet was formulated by direct compression method and designed by Design-Expert software with different types and numbers of super disintegrants.
9p vistarlord 24-06-2023 2 2 Download
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The recent pharmaceutical interest toward confinement effects on the physical state, solubility and release of drugs has paved the way to new material designs for drug delivery. Deeper understanding on how the pore size or the additional functionalities of the nanocarriers can influence the bioavailability of the cargo is nonetheless needed to explore further the potential of nanocarriers in this area.
8p vironald 15-12-2022 10 2 Download
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Robenacoxib (Onsior™) is a non-steroidal anti-inflammatory drug developed for canine and feline use for the control of pain and inflammation. It is available as both tablets and solution for injection. The objective of this study was to evaluate the safety of the interchangeable use of commercially available robenacoxib formulations when administered to cats orally using 6 mg tablets and subcutaneously using a solution for injection containing 20 mg/mL.
13p vigandhi 23-02-2022 7 1 Download
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Quantitation was performed with multiple reaction monitoring in the negative ionization mode. The response of the method was linear over a dynamic range of 0.5–500, 1.0–750, and 0.25–150 ng/mL for LOS, EXP-3174, and HCTZ, respectively. Extent of signal suppression/enhancement was examined through postcolumn infusion. The effect of matrix components was evaluated by postextraction spiking and calculation of the slope of calibration lines. The method was successfully applied to a bioequivalence study of 50 mg losartan and 12.
20p langthannam 29-12-2021 8 0 Download
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Developing a capillary zone electrophoresis method for determining simultaneously paracetamol and diclofenac in pharmaceutical formulations (2) Applying this method on the products circulated on the market. Materials and methods: Paracetamol and diclofenac in Zengesic and Ripaigesic film-coated tablets were used in this research. The method was developed and validated according to AOAC 2016 and ICH 2005 guidelines.
7p cothumenhmong11 06-05-2021 17 2 Download
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A new method for the determination of dopamine (DA) and paracetamol (PCT), based on the azo “coupling reaction with oxidized 2,4-dinitrophenylhydrazine (DNPH), has been established. This method was based on the fact that in the HCl buffer solution, potassium ioadate oxidized 2,4- dinitrophenylhydrazine to form the diazonium chloride at 0e5oC and then the diazonium ion reacted with the phenolic compounds to form azo-compounds
6p larachdumlanat129 14-01-2021 14 1 Download
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A new formulation of effervescent tablets containing microbial consortium was prepared for tomato with an objective to improve its survival and effectiveness. Three agriculturally beneficial microorganisms viz. Azotobacter chroococcum, Pseudomonas fluorescens and Bacillus megaterium were used in consortium. Tablets were prepared using wet granulation method using talc or compost as diluent. Effectiveness of these inoculants formulations was studied in tomato (Lycopersicon esculentum Mill.) in a greenhouse.
9p angicungduoc8 07-11-2020 13 1 Download
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To prepare extended release push - pull osmotic tablets containing 5 mg felodipine in 10.000 tablets/batch successfully; to prepare extended release push - pull osmotic tablets containing 5 mg felodipine in 10.000 tablets/batch successfully.
36p angicungduoc6 21-07-2020 10 2 Download
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The study was conducted at Department of Veterinary Clinical Medicine, Ethics and Jurisprudence. The polyherbal tablet comprising Artimisia maritima, Butea frondosa, Vernonia anthelmintica and Holarrhena antidysentrica was prepared and its anthelmintic efficacy and effect on body weight was studied on goats naturally infected with Haemonchus contortus.
10p angicungduoc5 12-06-2020 13 1 Download
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In the present study two diferent RSLC columns, Acclaim RSLC 120 C18, 5.0 µm, 4.6×150 mm (column A) and Acclaim RSLC 120 C18, 2.2 µm, 2.1×100 mm (Column B) were utilized for the analysis of velpatasvir (VPS) in presence of sofosbuvir (SFV), where due to the encountered fluorescent properties of VPS fluorescent detection at 405 nm after excitation at 340 nm (Method 1) was used for its detection where the non-fluorescent SFV did not interfere.
15p vijiraiya2711 27-05-2020 9 1 Download
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Paracetamol is an analgesic-antipyretic drug and Ibuprofen is a non-steroidal anti-infammatory drug. They are coformulated as tablets to improve analgesia, to simplify prescribing and to improve patient compliance. Three accurate, simple and sensitive spectrophotometric methods were developed for the simultaneous determination of Paraceta‑ mol and Ibuprofen in their co-formulated dosage form.
8p vijiraiya2711 27-05-2020 19 1 Download
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Ombitasvir/paritaprevir/ritonavir/dasabuvir (Viekira Pak®) are the newest medicines approved for use in the treatment of hepatitis C virus (HCV) and are available in tablet form as an oral combination. Specifically, these agents are indicated in the treatment of HCV in patients with genotype 1 infection.
8p vijiraiya2711 27-05-2020 11 0 Download
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Qualitative risk assessment methods are often used as the first step to determining design space boundaries; however, quantitative assessments of risk with respect to the design space, i.e., calculating the probability of failure for a given severity, are needed to fully characterize design space boundaries. Quantitative risk assessment methods in design and operational spaces are a significant aid to evaluating proposed design space boundaries.
12p caothientrangnguyen 09-05-2020 15 0 Download
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Currently available anti-ulcer drugs suffer from serious side effects which limited their uses and prompted the need to search for a safe and efficient new anti-ulcer agent. Boswellia gum resin (BR) emerged as a safe, efficient, natural, and economic potential cytoprotective agent. Thus, it is of medical importance to develop gastroretentive (GR) formulations of BR to enhance its bioavailability and antiulcer efficacy. Early attempts involved the use of organic solvents and non-applicability to large-scale production.
11p caothientrangnguyen 09-05-2020 12 0 Download
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Alcohol-induced dose dumping is a serious concern for the orally administered prolonged release dosage forms. The study was designed to optimize the independent variables, propylene glycol alginate (PGA), Eudragit RS PO (ERS) and coating in mucoadhesive quetiapine prolonged release tablets 200 mg required for preventing the alcohol-induced dose dumping. Optimal design based on response surface methodology was employed for the optimization of the composition. The formulations are evaluated for in vitro drug release in hydrochloric acid alone and with 40% v/v ethanol.
8p caothientrangnguyen 09-05-2020 13 0 Download
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Derivatized celluloses, such as methylcellulose (MC) and hydroxypropyl methylcellulose (HPMC), are of pharmaceutical importance and extensively employed in tablet matrices. Each batch of derivatized cellulose is thoroughly characterized before utilized in tablet formulations as batch-to-batch differences can affect drug release.
8p viuchiha2711 21-04-2020 5 1 Download
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Biphasic immediate-release (IR)/extended-release (ER) hydrocodone bitartrate (HB)/acetaminophen (APAP) 7.5/325-mg tablets are formulated with gastroretentive ER drug delivery technology that has been associated with clinically meaningful food effects in other approved products.
10p vienzym2711 30-03-2020 11 1 Download
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Ginger powder with high antioxidant activity, phenols, crude fibre and ash content was utilized for the preparation of ginger appetizing functional tablets. The flow properties of ginger powder categorized it good on the basis of carr compressibility (12.28%) and hausner ratio (1:1.14) and excellent (27o ) on the basis of angle of repose. The tablets were prepared by wet granulation method with varying concentrations of ginger powder (5g to 30g) using gulkand as natural binding agent and hypertonic sugar syrup.
8p nguaconbaynhay1 04-12-2019 19 0 Download
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Repeated dose medication usually maximizes adverse effects, while sustained release systems did not offer a fast onset of action. Etodolac was formulated to enable pulsatile and sustained drug release, which was chronologically more suitable as an anti-inflammatory drug. Eudragit RSPO, Eudragit RLPO, and HPMC K15M were added in the sustained release layer and tried in different ratios. Croscarmellose sodium or sodium starch glycolate were used as superdisintegrants for the fast release layer offering the loading dose for rapid onset of drug action.
11p trinhthamhodang1 14-11-2019 16 1 Download