Target therapy

Evaluate the initial treatment results of non-small cell lung cancer with EGFR and ALK concurrent mutations. Subjects and methods: A prospective study, non-controlled description, and longitudinal follow-up of 6 patients with stage IIIB-IV non-small cell lung cancer, with EGFR and ALK concurrent mutations, at the National Lung Hospital, from January 2022 to July 2023.

5p vipanly 28-10-2024 0 0   Download

The aim of the present study was to investigate the anti-colorectal cancer effect of the DNA-PK inhibitor NU7441, which inhibits DNA-DSB repair by blocking the NHEJ pathway, in the HCT116 cell line.

7p viengfa 29-09-2024 1 1   Download

Drug therapy to achieve the recommended target blood pressure remains the cornerstone of the management of hypertension. Today, there are strong evidences from randomized controlled trials that antihypertensive drugs are more effective than placebo at reducing cardiovascular mortality and morbidity.

8p vifaye 20-09-2024 2 0   Download

To give advantages and disadvantages in pediatric Craniospinal Irradiation (CSI) planning with general anesthesia, to evaluate some criteria about doses covering at Planning Target Volume (PTV), Organs At Risk (OARs) and junction areas.

7p vinatisu 29-08-2024 3 1   Download

This study presents the development of a software support system aimed at improving targeted treatment outcomes in non-small cell lung cancer (NSCLC) by utilizing genetic mutation analysis data. PubMed BERT model were generated to identify tumor gene mutated features associated with gene-drug responses.

14p vinatisu 23-08-2024 4 1   Download

Human epidermal growth factor receptor 2 (HER2) has been identified as a molecular target for breast cancer therapy, such as Trastuzumab (Herceptin®). This has been shown to improve patient survival substantially.

10p vibego 02-02-2024 6 0   Download

Ovarian cancer constitutes one of the most lethal gynecologic malignancies for females. Currently, early detection strategies and therapeutic options for ovarian cancer are far from satisfactory, leading to high diagnosis rates at late stages and disease relapses. New avenues of therapy are needed that target key processes in ovarian cancer progression.

20p vimichaelfaraday 25-03-2022 15 1   Download

The clinical outcome of Philadelphia chromosome-negative B cell acute lymphoblastic leukemia (Phneg B-ALL) varies considerably from one person to another after clinical treatment due to lack of targeted therapies and leukemia’s heterogeneity.

16p vielonmusk 21-01-2022 9 0   Download

The aim of this study was to analyze the level of CD33 expression in patients with newly diagnosed AML and determine its correlation with clinical characteristics. Methods: Samples were collected for analysis from AML patients at diagnosis. We evaluated the level of CD33 expression by flow cytometry analysis of bone marrow.

7p vielonmusk 21-01-2022 16 2   Download

We sought to understand the clinical course and molecular phenotype of patients who showed disease progression after programmed cell death ligand 1 (PD-L1) inhibitor treatment but subsequently responded to PD-1 inhibitor treatment. We also explored the response to PD-1-axis targeted therapy of classical Hodgkin lymphoma (cHL) according to genetically driven PD-L1 and programmed cell death ligand 2 (PD-L2) expression.

8p vielonmusk 21-01-2022 15 1   Download

Understanding of the functions of microRNAs in breast cancer and breast cancer stem cells have been a hope for the development of new molecular targeted therapies. Here, it is aimed to investigate the differences in the expression levels of let-7a, miR10b, miR-21, miR-125b, miR-145, miR-155, miR-200c, miR-221, miR-222 and miR-335, which associated with gene and proteins in MCF-7 (parental) and MCF-7s (Mammosphere/stem cell-enriched population/CD44+/CD24-cells) cells treated with paclitaxel. MCF7s were obtained from parental MCF-7 cells.

12p thiencuuchu 27-11-2021 15 2   Download

This study with the following objectives: Study some characteristics of immune disorders, analysis of association with target organ damage and activity level (SLEDAI score) in patients with severe systemic lupus erythematosus. Evaluation of treatment outcome of pulsed methylprednisolone therapy combined with baseline treatment after 12 weeks in patients with severe systemic lupus erythematosus.

34p petsematary 02-06-2021 26 4   Download

In recent years, many researches have been developing towards biocompatible improvement and cellular penetrating ability of dendrimers in order to use in diagnosis and treatment therapy for several type of cancer. In this study, to enhance biocompatibility, drug loading efficiency and cellular uptake of the polyamidoamine dendrimer, the dendrimer generation 3.0 (G 3.0) was conjugated with hexanoyl chloride and targeted with acid folic (G3.0-C6-FA).

7p tangtuy01 01-03-2016 51 3   Download

The HIV-1 proteinase (PR) has proved to be a good target for antiretroviral therapy of AIDS, and various PR inhibi-tors are now in clinical use. However, there is a rapid selec-tionof viral variantsbearingmutations in theproteinase that are resistant to clinical inhibitors. Drug resistance also involves mutations of the nucleocapsid/p1 and p1/p6 clea-vage sites ofGag, bothin vitroandin vivo.

7p research12 23-04-2013 37 2   Download

Numerous adhesion molecules have been described, and the molecular mechanisms of lymphocyte trafficking across the endothelium is starting to be elucidated. Identification of the molecules involved in the organoselec-tivity of this process would help in the targeting of drug therapy to specific tissues. Adhesion-regulating molecule-1 (ARM-1) is an adhesion-regulating molecule previously identified on T cells. It does not belong to any known families of adhesion molecules.

12p awards 06-04-2013 34 4   Download

RNAreprogramming represents anewconcept incorrecting genetic defects at theRNA level.However, for the technique to be useful for therapy, the level of reprogrammingmust be appropriate. To improve the efficiency of group I ribozyme-mediated RNA reprogramming, when using theTetrahy-menaribozyme, regions complementary to the target RNA have previously been extended in length and accessible sites in the targetRNAs have been identified.

0p awards 05-04-2013 35 3   Download

Anti-poxvirus therapies are currently limited to cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine], but drug-resistant strains have already been characterized. In the aim of finding a new target, the thymidy-late (TMP) kinase from vaccinia virus, the prototype of Orthopoxvirus, has been overexpressed inEscherichia coliafter cloning the gene (A48R).

12p dell39 27-03-2013 39 4   Download

The capsid protein of HIV-1 (p24) (CA) forms the mature capsid of the human immunodeficiency virus. Capsid assembly involves hexamerization of the N-terminal domain and dimerization of the C-terminal domain of CA (CAC), and both domains constitute potential targets for anti-HIV therapy.

13p galaxyss3 07-03-2013 44 4   Download

Epidermal growth factor receptor (EGFR)-mediated signal transduction is often hyperactivated in tumour cells and therefore considered a promising target for cancer therapy. A number of computational models have been developed which describe the pathway in great detail.

13p media19 04-03-2013 38 3   Download

Integrase (IN) is one of only three enzymes encoded in the genomes of all retroviruses, and is the one least characterized in structural terms. IN cata-lyzes processing of the ends of a DNA copy of the retroviral genome and its concerted insertion into the chromosome of the host cell.

21p viettel02 22-02-2013 28 3   Download