Target therapy

IHC has became an indispensable tool adjunct to the conventional pathology in daily practice. This technique is called immunohistochemistry because it was combined by two aspects including immunology and histochemistry applied directly on the tissue (taken from the patient lesion) section embedded in paraffin.

4p viuchiha 06-01-2025 1 1   Download

Drug therapy to achieve the recommended target blood pressure remains the cornerstone of the management of hypertension. Today, there are strong evidences from randomized controlled trials that antihypertensive drugs are more effective than placebo at reducing cardiovascular mortality and morbidity.

8p viharuno 03-01-2025 2 2   Download

Colorectal cancer (CRC) is one of the most common malignant cancers of the colon worldwide. Several novel approaches to cancer treatment have emerged, including gene therapy, targeted therapy, and adjuvant therapies.

7p viharuno 03-01-2025 3 2   Download

This study with the following objectives: Study some characteristics of immune disorders, analysis of association with target organ damage and activity level (SLEDAI score) in patients with severe systemic lupus erythematosus. Evaluation of treatment outcome of pulsed methylprednisolone therapy combined with baseline treatment after 12 weeks in patients with severe systemic lupus erythematosus.

34p petsematary 02-06-2021 29 4   Download

The HIV-1 proteinase (PR) has proved to be a good target for antiretroviral therapy of AIDS, and various PR inhibi-tors are now in clinical use. However, there is a rapid selec-tionof viral variantsbearingmutations in theproteinase that are resistant to clinical inhibitors. Drug resistance also involves mutations of the nucleocapsid/p1 and p1/p6 clea-vage sites ofGag, bothin vitroandin vivo.

7p research12 23-04-2013 39 3   Download

Numerous adhesion molecules have been described, and the molecular mechanisms of lymphocyte trafficking across the endothelium is starting to be elucidated. Identification of the molecules involved in the organoselec-tivity of this process would help in the targeting of drug therapy to specific tissues. Adhesion-regulating molecule-1 (ARM-1) is an adhesion-regulating molecule previously identified on T cells. It does not belong to any known families of adhesion molecules.

12p awards 06-04-2013 35 4   Download

RNAreprogramming represents anewconcept incorrecting genetic defects at theRNA level.However, for the technique to be useful for therapy, the level of reprogrammingmust be appropriate. To improve the efficiency of group I ribozyme-mediated RNA reprogramming, when using theTetrahy-menaribozyme, regions complementary to the target RNA have previously been extended in length and accessible sites in the targetRNAs have been identified.

0p awards 05-04-2013 37 3   Download

Anti-poxvirus therapies are currently limited to cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine], but drug-resistant strains have already been characterized. In the aim of finding a new target, the thymidy-late (TMP) kinase from vaccinia virus, the prototype of Orthopoxvirus, has been overexpressed inEscherichia coliafter cloning the gene (A48R).

12p dell39 27-03-2013 40 4   Download

The capsid protein of HIV-1 (p24) (CA) forms the mature capsid of the human immunodeficiency virus. Capsid assembly involves hexamerization of the N-terminal domain and dimerization of the C-terminal domain of CA (CAC), and both domains constitute potential targets for anti-HIV therapy.

13p galaxyss3 07-03-2013 47 4   Download

Epidermal growth factor receptor (EGFR)-mediated signal transduction is often hyperactivated in tumour cells and therefore considered a promising target for cancer therapy. A number of computational models have been developed which describe the pathway in great detail.

13p media19 04-03-2013 40 3   Download

Integrase (IN) is one of only three enzymes encoded in the genomes of all retroviruses, and is the one least characterized in structural terms. IN cata-lyzes processing of the ends of a DNA copy of the retroviral genome and its concerted insertion into the chromosome of the host cell.

21p viettel02 22-02-2013 29 3   Download

The discovery that signaling by the epidermal growth factor receptor (EGFR) plays a key role in tumorigenesis prompted efforts to target this receptor in anticancer therapy. Two different types of EGFR-targeted ther-apeutic agents were subsequently developed: mAbs, such as cetuximab and panitumumab, which target the extracellular domain of the receptor,

7p mobifone23 18-01-2013 48 3   Download

It is becoming increasingly clear that signals generated in tumor microenvi-ronments are crucial to tumor cell behavior, such as survival, progression and metastasis. The establishment of these malignant behaviors requires that tumor cells acquire novel adhesion and migration properties to detach from their original sites and to localize to distant organs.

15p cosis54 05-01-2013 36 5   Download

HIV-1 reverse transcriptase (RT) has two associated activities, DNA poly-merase and RNase H, both essential for viral replication and validated drug targets. Although all RT inhibitors approved for therapy target DNA poly-merase activity, the search for new RT inhibitors that target the RNase H function and are possibly active on RTs resistant to the known non-nucleoside inhibitors (NNRTI) is a viable approach for anti-HIV drug development.

14p cosis54 05-01-2013 58 4   Download

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : The application of carbon nanotubes in target drug delivery systems for cancer therapies

22p dauphong11 06-02-2012 77 8   Download

Chỉ trong vài thập niên của cuối thế kỷ trước đã có một bước đột phá về sự hiểu biết bệnh ung thư nhờ các tiến bộ về sinh học. Các tiến trình sinh học ung thư ngày càng được hiểu rõ hơn: các đường dẫn tín hiệu tăng trưởng tế bào, các gen điều hòa chu trình tế bào, sự chết tế bào theo lập trình, sự sinh mạch... Chúng ta có được những cơ sở lôgic cho một liệu pháp mới toanh: liệu pháp nhắm trúng đích (targeted therapy) nhờ vào các hiểu...

6p ducthang9494 28-01-2012 213 43   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences

18p dauphong4 03-01-2012 68 6   Download

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences

11p dauphong3 03-01-2012 50 4   Download

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer

12p dauphong3 03-01-2012 67 6   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Targeted therapy in lymphoma

10p toshiba24 06-12-2011 52 6   Download