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Báo cáo khoa học: Substrate specificity of vaccinia virus thymidylate kinase
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Anti-poxvirus therapies are currently limited to cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine], but drug-resistant strains have already been characterized. In the aim of finding a new target, the thymidy-late (TMP) kinase from vaccinia virus, the prototype of Orthopoxvirus, has been overexpressed inEscherichia coliafter cloning the gene (A48R).
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