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Báo cáo khoa học: Probing the molecular determinants of aniline dioxygenase substrate specificity by saturation mutagenesis
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Aniline dioxygenase is a multicomponent Rieske nonheme-iron dioxygenase enzyme isolated from Acinetobactersp. strain YAA. Saturation mutagen-esis of the substrate-binding pocket residues, which were identified using a homology model of theasubunit of the terminal dioxygenase (AtdA3), was used to probe the molecular determinants of AtdA substrate specificity.
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