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Báo cáo khoa học: Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:14

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ArylamineN-acetyltransferases (NATs) play an important role in both the detoxification of arylamine and hydrazine drugs and the activation of aryl-amine carcinogens. Because the catalytic triad, Cys-His-Asp, of mammalian NATs has been shown to be essential for maintaining protein stability, ren-dering it impossible to assess alterations of the triad on catalysis, we explored the impact of the highly conserved proximal residue

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Nội dung Text: Báo cáo khoa học: Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190

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