Termed cancer stem cells

Ebook "Mesenchymal stem cells and immunomodulation" explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to discover methods of suppressing the causal inflammatory response.

94p tracanhphuonghoa1007 22-04-2024 4 2   Download

Neuroblastoma (NB) is a childhood malignant tumor,50% of high-risk NB children still have recurrence, and the long-term survival rate is very low. NB tumors expressing high levels of BDNF/TrkB are associated with poor survival outcomes.In this study, we show that the trends of serum concentration of BDNF at different growth stages after birth, and explore the relationship with NB replase.

9p vioracle 29-09-2023 3 2   Download

CD133 has been identified as a putative cancer stem cell marker in colorectal cancer (CRC). However, the clinical and prognostic significance of CD133 in CRC remains controversial. Methods: Publications were identified which assessed the clinical or prognostic significance of CD133 in CRC up to October 2012. A meta-analysis was performed to clarify the association between CD133 expression and clinical outcomes.

6p vijisoo2711 30-09-2020 10 1   Download

Atypical teratoid rhabdoid tumor (ATRT) patients display a dismal median overall survival of less than 1 year. A consistent fraction of cases carries de-novo SMARCB1/INI1 constitutional mutations in the setting of the “rhabdoid tumor predisposition syndrome” and the outcome is worst in infant syndromic ATRT patients.

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Current treatment of ovarian cancer patients with chemotherapy leaves behind a residual tumor which results in recurrent ovarian cancer within a short time frame. We have previously demonstrated that a single short-term treatment of ovarian cancer cells with chemotherapy in vitro resulted in a cancer stem cell (CSC)-like enriched residual population which generated significantly greater tumor burden compared to the tumor burden generated by control untreated cells.

22p virose2711 24-09-2020 17 0   Download

Accumulating evidences suggest that tumors are driven by a small population of cells, termed “cancer stem cells” (CSCs), which may be resistant to current therapeutic approaches. In breast carcinoma, the CSCs have been identified as a CD44+ /CD24− cell population.

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It has been proposed that cancer establishment, maintenance, and recurrence may be attributed to a unique population of tumor cells termed cancer-initiating cells (CICs) that may include characteristics of putative cancer stem cell-like cells.

10p vibaku2711 22-07-2020 15 2   Download

No standard of care is established for plasmablastic lymphoma (PBL) and prognosis remains extremely poor, given that patients relapse early after chemotherapy and display resistance to commonly applied cytostatic drugs.

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Prior to the Separation on October 27, 2004, we were a business division of Old DreamWorks Studios, the diversified entertainment company formed in October 1994 by Steven Spielberg, Jeffrey Katzenberg and David Geffen. As a division of Old DreamWorks Studios, we conducted our business primarily through Old DreamWorks Studios’ animation division. On October 28, 2004, our Class A common stock began trading on the New York Stock Exchange in connection with our initial public offering.

32p hoangphiyeah1tv 24-04-2013 48 4   Download

Finance is all about the systems, institutions and instruments involved in the transfer of funds between individuals, businesses and governments. This includes vital, short-run decisions such as cash management and credit policy, which affect the survival of an organisation, as well as long-term decisions such as investment in plant and equipment, fund-raising, and mergers and takeovers, which determine the wealth of stakeholders. Your studies in finance can lead to career opportunities and also provide useful personal money management strategies.

77p bi_ve_sau 05-02-2013 62 7   Download

Conditions experienced early in life or in utero have been shown to have persistent and long- term effects on health, education, and socioeconomic outcomes (see seminal work by Stein et al. (1975) and more recent papers by Maccini and Yang (2009) and Maluccio et al. (2009)). Barker (1998) argues that health shocks suffered in utero can cause irreversible adaptations to the local food environment and that children cannot catch up even if they later have good nutrition and health care.

39p can_thai 12-12-2012 60 3   Download

Strategic Approach: 1) Utilize high throughput genomic/genetic platforms to characterize genetic susceptibility biomarkers of childhood cancer/cancer stem cells and to identify targets for novel tumour stem cell-directed molecular therapeutics, 2) develop advanced mechanisms and ethical/regulatory guidelines to conduct population-based genetic/genomic studies in children, 3) link biobanks to high-throughput functional analysis of individual tumours to assess responses to drugs and growth factors, adverse reactions to treatment, long-term side effects of treatment, and genome-wide ex...

0p connhobinh 10-12-2012 58 2   Download