The clinical applications

5-Fluorouracil (5FU) is a primary chemotherapeutic agent used to treat oral squamous cell carcinoma (OSCC). However, the development of drug resistance has significantly limited its clinical application. Therefore, there is an urgent need to determine the mechanisms underlying drug resistance and identify effective targets.

16p vishanshan 27-06-2024 2 1   Download

The clinical value and impact in patients with EGFR mutation on survival outcomes is further needed to be elucidated to decide whether the application of EGFR-TKIs was appropriate in early lung adenocarcinoma (LUAD) stage appearing as subsolid nodules.

9p vishanshan 27-06-2024 4 1   Download

Whole-mount histopathology (WMH) has been a powerful tool to investigate the characteristics of prostate cancer. However, the latest advancement of WMH was yet under summarization. In this review, we offer a comprehensive exposition of current research utilizing WMH in diagnosing and treating prostate cancer (PCa), and summarize the clinical advantages of WMH and outlines potential on future prospects.

13p vishanshan 27-06-2024 2 1   Download

Over the past few decades, the utilization of Artificial Intelligence (AI) has surged in popularity, and its application in the medical field is witnessing a global increase. Nevertheless, the implementation of AI-based healthcare solutions has been slow in developing nations like Pakistan. This unique study aims to assess the opinion of clinical specialists on the future replacement of AI, its associated benefits, and its drawbacks in form southern region of Pakistan.

11p vishanshan 27-06-2024 1 1   Download

Tumor hypoxia is associated with prostate cancer (PCa) treatment resistance and poor prognosis. Pimonidazole (PIMO) is an investigational hypoxia probe used in clinical trials. A better understanding of the clinical significance and molecular alterations underpinning PIMO-labeled tumor hypoxia is needed for future clinical application.

12p vikoch 27-06-2024 1 1   Download

To explore the clinical value of tumor abnormal protein (TAP) in the diagnosis and prognosis evaluation of prostate cancer. Methods This study enrolled a total of 265 patients who underwent prostate biopsy procedures from December 2017. TAP levels were assayed in their blood samples using a validated TAP testing kit.

7p vikoch 27-06-2024 1 1   Download

Esophageal cancer (EC) is a deadly disease with limited therapeutic options. Although circulating tumor DNA (ctDNA) could be a promising tool in this regard, the availiable evidence is limited. We performed a systematic review and meta-analysis to summarize the clinical applicability of the next-generation sequencing (NGS) and droplet digital polymerase chain reaction (ddPCR) technology on the ctDNA detection of the EC and listed the current challenges.

12p vikoch 27-06-2024 1 1   Download

Cancer cachexia is associated with impaired functional and nutritional status and worse clinical outcomes. Global Leadership Initiative in Malnutrition (GLIM) consensus recommended the application of GLIM criteria to diagnose malnutrition in patients with cachexia. However, few previous study has applied the GLIM criteria in patients with cancer cachexia.

11p vikoch 27-06-2024 2 1   Download

Recently, propolis has shown potential cardioprotective effects against myocardial infarction. However, challenges in its clinical application have arisen, primarily due to concerns regarding dosage and potential adverse effects. To address this, we suggest integrating propolis into polyvinyl alcohol (PVA)/gelatin hydrogel to regulate the localized release of propolis at infarcted sites.

7p visergeyne 18-06-2024 0 0   Download

This volume has been authored by internationally reputed experts from Japan and Europe and reflects the state of the art in the field of pediatric surgery. The first section on constipation and incontinence shows the fast pace of research in Japan on the subject. In particular, pathophysiological studies have led to improved diagnostic techniques and the clinical application of anorectal manometry.

241p vimeyers 29-05-2024 2 2   Download

This book is intended to aid course participants in their lessons and practi­ cal exercises and also to guide the clinical practitioner in the application of AO/ ASIF principles. Basel, September 1988 B.SPIESSL VII Acknowledgments I have received help from many sources. The colleagues of the past 20 years who have contributed to the case material upon which this manual is based are too numerous to credit by name.

387p vimeyers 29-05-2024 4 2   Download

The chapters of this book describe the principles, insertion technique, and clinical applications of double-balloon endoscopy, which will become the gold standard of enteroscopy and may well eliminate the need for intraoperative enteroscopy in many patients. As such, this book will provide an invaluable source of reference for all practitioners working in the field.

124p vimeyers 29-05-2024 4 2   Download

Ebook Gray’s surface anatomy and ultrasound includes the following main contents: Concise text and high quality illustrations, photographs, CT, MRI and ultrasound scans provide a clear, integrated understanding of the anatomical basis for modern clinical practice; Highly accessible and at a level appropriate for medical students and a wide range of allied health students and professionals;...

228p vimeyers 29-05-2024 2 2   Download

This reference provides a concise overview of the key principles in dose selection and optimization and demonstrates applicability to recent successful new drug applications. Compiling key issues and current research on safety, efficacy, and clinical pharmacology, and PK-PD, this volume critically highlights the multidisciplinary nature of drug development and spans the fields of pharmacokinetics, clinical pharmacology, biostatistics, and experimental medicine.

301p vimeyers 29-05-2024 4 2   Download

Ebook "Biomedical nanotechnology: Methods and protocols" is to provide an overview of biomedical nanotechnology, from the conception of novel materials in the laboratory to the application of such structures in the clinic. After a brief introductory chapter, the first section consists of protocol chapters which provide practical information on the synthesis of a variety of solution-phase and surface-bound nanomaterials and their application in sensing, imaging, and/or therapeutics; most chapters provide step-by-step instructions and insight into overcoming possible pitfalls and challenges.

447p dongmelo 27-05-2024 3 2   Download

Ebook "Lymphangiogenesis in cancer metastasis" covers all aspects of this new field from the fundamental role that protein growth factors and their receptors play in lymphangiogenesis to the potential application of these advances to cancer diagnosis and treatment. Other clinical aspects explored include the mechanisms and importance of lymph node metastasis, the role of the lymphatics in lymphangioleiomyomatosis and Kaposi’s sarcoma, and approaches for imaging lymphatics in cancer.

254p dongmelo 27-05-2024 6 2   Download

To evaluate the results of soft tissue defect treatment with ALT composite flaps in covering secondary soft tissue defects after radical tumors resection. Method: From October 2017 to April 2023, we performed a series of 10 single-stage surgeries using composite anterior lateral thigh flap to cover secondary tissue defects in 2 cases covered Achilles tendon defects and 8 cases covered secondary defects after resection of tumors.

6p viambani 21-05-2024 2 1   Download

Describe the clinical and laboratory features of neuroblastoma in children; distribution of pediatric neuroblastoma stages according to the INRGSS 2009 classification and its value in predicting survival outcomes.

9p vicarlos 16-05-2024 1 0   Download

This book provides a resource for better understanding of surgical procedures and potential complications in general terms. The application of this material will depend on the individual patient and clinical context. Part 1 book "Cardio thoracic, vascular, renal and transplant surgery" includes content: Introduction; blood transfusion; arterial surgery; venous surgery; amputation surgery.

103p zizaybay1101 30-04-2024 2 2   Download

Ebook "Complement therapeutics" highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis.

323p ladongphongthanh1008 22-04-2024 3 3   Download