The first report

Metformin is an oral antidiabetic drug from the biguanide class and it is the first-line drug chosen for the treatment of type 2 diabetes. This is a drug on the list of pharmaceutical substances required to report bioequivalence study data when registering the drug. Objectives: (1) To develope a capillary zone electrophoresis method for determining metformin hydrochloride in human plasma. (2) To validate the method.

10p viuchiha 03-01-2025 3 1   Download

In the present study, cooling of PV module using a paraffin-based phase change material (PCM) in hot climate of Vietnam is investigated. Thermal modelling is first validated against experimental data reported in literature and then transient thermal simulations are carried out for a duration of 24 hours to assess the effect of PCM itself and PCM with internal fins.

6p vibenya 31-12-2024 1 1   Download

In direct speech the information go from people firstly to second (people firstly said direct to people second.In reported speech the information go from firstly to second person to third person. By then sentence is changed about gammar

26p xuka3012 28-02-2010 437 230   Download

The focus of this thesis was to study the chemotaxonomic relationship of selected southern Australian marine brown algae of the genera Cystophora and Sargassum. Consequently, this resulted in the isolation and structure elucidation of six new terpenoids from two southern Australian marine brown algae Cystophora moniliformis and Sargassum fallax together with 10 previously reported natural products. As a result of the re-isolation of these known secondary metabolites, updated and complete structural characterisation data could be provided for the first time for 7 of these compounds.

132p runthenight07 01-03-2023 9 3   Download

This thesis examines the strategic and potentially legitimising nature of voluntary environmental reporting. First, the thesis examines the relationship between emission levels on the National Pollutant Inventory and the quantity of total voluntary environmental disclosures, voluntary emission disclosures and positive voluntary environmental disclosures in annual reports. Second, an examination of changes in the quantity of disclosures discussing compliance with the National Pollutant Inventory and/or disclosures concerning pollution emissions is undertaken.

218p runthenight04 02-02-2023 6 2   Download

This research is comprised of three interrelated stages of a broader study of the climate change-related corporate governance disclosure practices of Australian companies. The first stage of the study investigates the climate change-related corporate governance disclosure practices of five major Australian energy-intensive companies over a 16-year period (from 1992 to 2007). The five companies are BHP Billiton, Caltex, Origin Energy, Rio Tinto and Santos Limited.

240p runthenight04 02-02-2023 9 2   Download

The research "Social and environmental reporting practices of the gambling industry: an Australian perspective" explores the corporate social and environmental disclosure (CSD) practices of Australian gambling companies to understand what information is reported in CSDs, and why. The first part of the study performs an analysis of the two gambling companies; annual reports (1995-2009) to investigate the changing trend of the CSDs.

272p runthenight04 02-02-2023 6 2   Download

India is one of the most intimidating business environments for first generation entrepreneurs. One has to become entrepreneur because there is no better option of work. Global Entrepreneurship Monitor 2013- India report suggests introduction of entrepreneurship education at undergraduate university level as well as at engineering and technical institutions.

9p guineverehuynh 22-06-2020 10 1   Download

In the first lesson of inorganic chemistry lab, preparing and testing solutions are two basic tasks needed to perform well. Dissolving a solid solute in the solvent or diluting the stock solution (a dilution series by using two techniques that are making parallel dilutions and serial dilutions) is to prepare solution with desired concentration of solute or desired volume.

11p suplo28475858 24-05-2020 37 3   Download

AR-42, a new orally bioavailable, potent, hydroxamate-tethered phenylbutyrate class I/IIB histone deacetylase inhibitor currently is under evaluation in phase 1 and 2 clinical trials and has demonstrated activity in both hematologic and solid tumor malignancies. This report focuses on the preclinical characterization of the pharmacokinetics of AR-42 in mice and rats.

9p caothientrangnguyen 09-05-2020 18 3   Download

This case report represents the first-time use of 4DCT to localize parathyromatosis. Parathyromatosis is a rare but problematic cause of recurrent hyperparathyroidism. Ultrasound and 4DCT may represent the best imaging modalities for identification and perioperative management to remove all affected tissue without reseeding. (AACE Clinical Case Rep. 2019;5:e384-e387)

4p caothientrangnguyen 09-05-2020 13 2   Download

The first report of pestalotiopsis sp. causing crown rot disease on strawberries in Dalat. Study on the pathogens causing strawberries crown rot disease was complied with the methodology of Koch. Results from isolating 150 samples of infected plant parts collected from three strawberry cultivated areas in Dalat (Ward 7, Ward 8 and Ward 12) indicated that there were 327 isolates belonging to six fungal species.

13p lehasiphuong 22-05-2018 40 2   Download

Research objectives: The first research objective is to determine the factors of measurement quality of(financial reporting information) FRI of listed companies in Vietnam. The second research objective is aimed at determining the impact of CG characteristics on the quality of FRI. The last research objective is to assess the reality of quality of FRI and the impact of CG on the quality of FRI of listed companies in Vietnam.

24p change03 06-05-2016 67 3   Download

The Toyota Motor Corporation was founded in 1937 by Kiichiro Toyoda. It originally started as a subsidiary of his father’s company Toyoda Industries. The first vehicle, the Toyota AA, was produced in 1936 whilst the company was still associated with Toyoda. The brand as we know it became established as an independent company in 1937 and changed their name to Toyota. The name change was implemented to signify a separation of work and home, to simplify the pronunciation and because it only took 8 brush strokes (which is considered lucky) to write in Japanese.

26p grace_lady 12-07-2013 387 47   Download

Register your name and address on the Web site in order to ------- a purchase online. (A) make (B) shop (C) owe (D) use 102. All ------- for time off must go through the Human Resources Department first. (A) request (B) requests (C) requested (D) requesting 103. Despite it being his first time in an authority position, Mark led the project remarkably -------. (A) partly (B) even (C) yet (D) well 104. The detailed analyses of third and fourth quarter sales are included in ------- final report. (A) he (B) his (C) him (D) himself...

10p logomay 12-06-2013 93 15   Download

A series of thylakoid membrane proteins, including PsbX, PsbY and PsbW, are synthesized with cleavable signal peptides yet inserted using none of the known Sec/SRP/Tat/ Oxa1-type insertion machineries. Here, we show that, although superficially similar to Sec-type signal peptides, these thylakoidal signal peptides contain very different determinants.

11p system191 01-06-2013 46 4   Download

The interaction between the c11ring and thececomplex, forming the rotor of theIlyobacter tartaricus ATP synthase, was probed by surface plasmon resonance spectroscopy andin vitro reconstitution analysis. The results pro-vide, for the first time, a direct and quantitative assessment of the stability of the rotor. The data indicated very tight binding between the c11ring and the cecomplex, with an apparent Kd value of approximately 7.4 nm.

13p research12 29-04-2013 47 3   Download

The Na + /H + exchanger is a ubiquitous membrane protein of bacteria, plants and mammals. The first isoform discov-ered (NHE1) is present on the mammalian plasma mem-brane and transports oneH + out of cells inexchange for one extracellular Na + . With solubilization in standard SDS/ PAGE buffer, this protein had a high tendency to aggregate when subjected to elevated temperature. The aggregates were stable and did not dissociate in high concentrations of SDSor 2-mercaptoethanol.

9p research12 29-04-2013 46 3   Download

For the biosynthesis of punicic acid (18:3 D9Z,11E,13Z )a (11,14)-linoleoyl desaturase activity has been proposed. To isolate this acyl-lipid-desaturase, PCR-based cloning was used. This approach resulted in the isolationof twocomplete cDNAs. The first isolated full-length cDNA harbors a sequence of 1350 bp encoding a protein of 395 amino acids. The second cDNA was 1415 bp long encoding a protein of 387 amino acids.

8p research12 29-04-2013 41 3   Download

Two novel pore-forming peptides have been isolated from the venom of the South-African scorpion Opistophtalmus carinatus. These peptides,designated opistoporin 1 and 2, differ by only one amino acid and belong to a group of a-helical,cationic peptides. For the first time,a comparison of the primary structures ofa-helical pore-forming peptides from scorpion venom was undertaken.

12p research12 29-04-2013 45 3   Download