The molecular basis

This leading textbook in the field examines the mechanisms underlying toxicity, particularly the events at the molecular level and the factors that determine and affect toxicity. The new edition is updated to reflect the latest research into the biochemical basis of toxicology and the growing concerns over the adverse effects of drugs, environmental pollution, and occupational hazards.

467p vimeyers 29-05-2024 4 2   Download

Part 1 book "Chromatography and separation science" includes contents: Relating chromatography to separations, simple separation methods, equilibrium processes in separations, the molecular basis of separation, masstransport and separation, chromatographic methods.

113p dianmotminh01 14-05-2024 2 0   Download

Three chalcones with a 2,3-dihydrobenzofuran linkage were analyzed by applying the density functional theory (DFT) and B3LYP approach with the 6-311G(d,p) basis set in this report. Spectroscopic and theoretical analyses were used to examine the structures of these three chalcones. The chalcone molecules' HOMO-LUMO energy was determined. Chemical reactivity parameters and molecular electrostatic surface potential (MESP) plots were obtained to gain useful insight into the distribution of charge density.

11p dianmotminh02 03-05-2024 3 2   Download

Ebook "Molecular biology of metal homeostasis and detoxification: From microbes to man" brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription.

519p ladongphongthanh1008 22-04-2024 7 2   Download

Ebook "CtBP family proteins" are unique in several aspects. They were the first among proteins containing a metabolic enzyme fold to be implicated in transcriptional regulation. The vertebrate CtBPs exhibit distinct nuclear and cytosolic activities. The crystal struaures of CtBPl and molecular modeling studies have illuminated the molecular basis of its dual activity and the interaction with target peptides.

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Ebook "Proteomics and protein-protein interactions: Biology, chemistry, bioinformatics, and drug design" attempts to bridge the two extreme ends of protein science: on one end, systems proteomics, which describes, at a system level, the intricate connection network that proteins form in a cell, and on the other end, protein chemistry and biophysics, which describe the molecular properties of individual proteins and the structural and thermodynamic basis of their interactions within the network.

325p ladongphongthanh1008 22-04-2024 5 2   Download

Ebook "Evolutionary transitions to multicellular life: Principles and mechanisms" integrates our understanding of the factors and processes underlying the evolution of multicellularity by providing several complementary perspectives (both theoretical and experimental) and using examples from various lineages in which multicellularity evolved.

489p ladongphongthanh1008 22-04-2024 4 2   Download

Ebook "The plant cytoskeleton" is divided into three sections: (1) Molecular Basis of the Plant Cytoskeleton; (2) Cytoskeletal Reorganization in Plant Cell Division; and (3) The Cytoskeleton in Plant Growth and Development. This book is aimed at serving as a resource for anyone who wishes to learn about the plant cytoskeleton beyond ordinary textbooks.

333p tracanhphuonghoa1007 22-04-2024 2 1   Download

Ebook "Photochemistry: A modern theoretical perspective" offers an introduction to photochemistry for students with a minimal background in physical chemistry and molecular quantum mechanics. The focus is from a theoretical perspective and highlights excited state dynamics. The authors, experienced lecturers, describe the main concepts in photochemical and photophysical processes that are used as a basis to interpret classical steady-state experimental results (essentially product branching ratios and quantum yields) and the most advanced time-resolved techniques.

267p tracanhphuonghoa1007 22-04-2024 4 3   Download

Genome wide association studies have identified > 200 susceptibility loci accounting for much of the heritability of multiple sclerosis (MS). Epstein-Barr virus (EBV), a memory B cell tropic virus, has been identified as necessary but not sufficient for development of MS. The molecular and immunological basis for this has not been established.

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Pancreatic neuroendocrine tumors (PANETs) are rare, slow growing cancers that often present with local and distant metastasis upon detection. PANETS contain distinct karyotypes, epigenetic dysregulation, and recurrent mutations in MEN1, ATRX, and DAXX (MAD+); however, the molecular basis of disease progression remains uncharacterized.

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Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. However, despite extensive clinical and genomic studies, the molecular basis of AD development and progression remains elusive.

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Glioblastoma multiforme (GBM) constitutes nearly half of all malignant brain tumors and has a median survival of 15 months. The standard treatment for these lesions includes maximal resection, radiotherapy, and chemotherapy; however, individual tumors display immense variability in their response to these approaches. Genomic techniques such as whole-exome sequencing (WES) provide an opportunity to understand the molecular basis of this variability.

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Ebook "Nano-bio probe design and its application for biochemical analysis" eview the concept of nano-bio probe design for biochemical analysis on the basis of their recent published works. A unique biochemical analysis technology based on fluorescence polarization enhanced by nanoparticles is described here with successful applications in environmental monitoring, rapid and sensitive sensing protease activity and high-throughput screening of inhibitors.

83p coduathanh1122 27-03-2024 1 1   Download

Ebook "Molecular response functions for the polarizable continuum model: Physical basis and quantum mechanical formalism" presents the main aspects of the response functions theory (RFT) for molecular solutes described within the framework of the Polarizable Continuum Model (PCM). PCM is a solvation model for a Quantum Mechanical molecular system in which the solvent is represented as a continuum distribution of matter.

70p coduathanh1122 27-03-2024 3 0   Download

Ebook "Protein misfolding, aggregation, and conformational diseases - Part B: Molecular mechanisms of conformational diseases" continues to fill the gap in protein review and protocal literature while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders.

557p cotieubac1004 15-03-2024 0 0   Download

Ebook "Molecular biology of human cancers: An advanced student’s textbook" is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.

519p cotieubac1004 15-03-2024 1 0   Download

Part 2 book "Molecular biology of drug addiction" includes content: Influence of environmental and hormonal factors in sensitivity to psychostimulants; development and expression of behavioral sensitization - temporal profile of changes in gene expression; new advances in the identification and physiological roles of the components of the endogenous cannabinoid system; opioid system involvement in cannabinoid tolerance and dependence, genetic basis of ethanol reward,... and other contents.

215p muasambanhan08 04-03-2024 1 1   Download

Part 1 book "The innate immune response to noninfectious stressors - Human and animal models" includes contents: An overview of the innate immune response to infectious and noninfectious stressors, homeostatic inflammation as environmental adaptation strategy, the molecular basis of the immune response to stressed cells and tissues, modulation of innate immunity by hypoxia.

123p muasambanhan08 04-03-2024 5 1   Download

The cellular mechanisms of valvular heart disease have not been elucidated until the last decade. To date, there is no medical therapy that is FDA or CE mark approved for the treatment and/or slowing the progression of this disease. This textbook will provide the cellular basis for medical therapy. Over the past decade, research laboratories are more and more evolving into valvular biology programs from the traditional vascular biology.

164p duongthandue0501 28-02-2024 7 1   Download