The seven secrets

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Báo cáo khoa học: Elements of the C-terminal t peptide of acetylcholinesterase that determine amphiphilicity, homomeric and heteromeric associations, secretion and degradation

The C-terminal t peptide (40 residues) of vertebrate acetyl-cholinesterase (AChE) T subunits possesses a series of seven conserved aromatic residues and forms an amphiphilic a-helix; it allows the formation of homo-oligomers (mono-mers, dimers and tetramers) and heteromeric associations with the anchoringproteins, ColQ and PRiMA, which contain a proline-rich motif (PRAD). We analyzed the influenceofmutations in the t peptideofTorpedoAChETon oligomerization and secretion.

12p dell39 03-04-2013 39 4 Download

Báo cáo khoa học: PC1⁄3, PC2 and PC5⁄6A are targeted to dense core secretory granules by a common mechanism

There are seven members of the proprotein convertase (PC) family of secre-ted serine proteases that cleave their substrates at basic amino acids, thereby activating a variety of hormones, growth factors, and viruses. PC1⁄3, PC2 and PC5⁄6A are the only members of the PC family that are targeted to dense core secretory granules, where they carry out the process-ing of proteins that are secreted from the cell in a regulated manner.

9p media19 04-03-2013 20 2 Download