The vascular endothelium

Laparoscopic nephrectomy is a preferred technique for living kidney donation. However, positivepressure pneumoperitoneum may have an unfavorable effect on the remaining kidney and other distant organs due to inflamed vascular endothelium and renal tubular cell injury in response to increased systemic inflammation. Early detection of vascular endothelial and renal tubular response is needed to prevent further kidney injury due to increased intraabdominal pressure induced by pneumoperitoneum.

17p vizhangzhidong 29-12-2021 11 0   Download

The Follicle Stimulating Hormone receptor (FSHR) is expressed by the vascular endothelium in a wide range of human tumors. It was not determined however if FSHR is present in metastases which are responsible for the terminal illness.

8p vijennie2711 29-09-2020 6 1   Download

Resistin, adipocyte-secreting adipokine, may play critical role in modulating cancer pathogenesis. The aim of this study was to investigate the effects of resistin on HCC adhesion to the endothelium, and the mechanism underlying these resistin effects.

9p virose2711 25-09-2020 13 1   Download

The Intratumoral Microvessel Density (IMVD) is commonly used to quantify tumoral vascularization and is usually assessed by pan-endothelial markers, such as CD31. Endoglin (CD105) is a protein predominantly expressed in proliferating endothelium and the IMVD determined by this marker measures specifically the neovascularization.

11p vibaku2711 22-07-2020 11 1   Download

Uric acid is synthesized mainly in the liver, intestines and the vascular endothelium as the end product of an exogenous pool of purines, and endogenously from damaged, dying and dead cells, whereby nucleic acids, adenine and guanine, are degraded into uric acid. Mentioning uric acid generates dread because it is the established etiological agent of the severe, acute and chronic inflammatory arthritis, gout and is implicated in the initiation and progress of the metabolic syndrome.

7p trinhthamhodang1 14-11-2019 28 1   Download

Aging is a main risk factor for development of cardiovascular diseases associated with the impairment of endothelial function in both sexes. In the present study, age-related changes in vascular responsiveness, epigenetic modifications of vessel wall, and blood biomarkers related to endothelial functions were examined in an age- and sex-dependent manner.

11p nutifooddau 27-01-2019 24 2   Download

(bq) part 1 book “managing cardiovascular complications in diabetes” has contents: the vascular endothelium in diabete, new biomarkers of cardiovascular disease in diabetes, kidney disease in diabetes, vascular imaging, hypertension and cardiovascular disease and its management,… and other contents.

180p tieu_vu15 07-09-2018 26 1   Download

Sir John Vane named vascular endothelium ‘the maestro of blood circula-tion’. Recently, ‘the maestro’ has become a target for pharmacotherapy of atherothrombotic and diabetic vasculopathies with well known cardio-vascular drugs belonging to the families of Angiotensin Converting Enzyme inhibitors, HMG CoA reductase inhibitors or b1 -Adrenoceptor antagonists. These drugs became upgraded to a position of the pleiotropic endothelial drugs.

12p fptmusic 11-04-2013 36 1   Download

Although group IIA secretory phospholipase A2 (sPLA2-IIA) is known to be abundantly present in the joints of patients with rheumatoid arthritis (RA), expression of other sPLA2 s in this disease has remained unknown. In this study, we examined the expression and localization of six sPLA2s (groups IIA, IID, IIE, IIF, V and X) in human RA.

18p awards 05-04-2013 38 2   Download

NO is a gaseous molecule, synthesized by NO synthase (NOS), an enzyme that catalyses the oxidation of L-arginine to NO and L-citrulline. At least two types of NOS can be reported, constitutive NOS (cNOS) and inducible NOS (iNOS) (168) . cNOS is produced by many cells in the upper and lower respiratory system, such as parasympathetic vasodilator nerves, endothelial cells and ciliated mucosa cells (169) .

81p nhacnenzingme 28-03-2013 51 4   Download

The recruitment of leukocytes from the circulation into tissues requires leu-kocyte migration through the vascular endothelium. The mechanisms by which leukocytes attach and firmly adhere to the endothelial cell surface have been studied in detail. However, much less is known about the last step in this process, the diapedesis of leukocytes through the vascular endo-thelium.

9p inspiron33 25-03-2013 38 4   Download

Leukocyte adhesion deficiency II (LAD II) belongs to a group of human congenital diseases in which the interactions of leukocytes with the vascular endothelium are strongly impaired. LAD II is based on a defect in the syn-thesis of fucosylated glycostructures. This leads to an immunodeficiency owing to the absence of functional selectin ligands and to strong psycho-motor defects, as a result of as-yet unknown reasons.

9p inspiron33 25-03-2013 32 3   Download

In the 16th century, Leonardo da Vinci had described “The narrowing of the passage of blood vessels, thickening of the coats of these vessels and hardening of arteries”. This is the first documentation of atherosclerosis, but today our understanding of atherogenesis as a process of a chronic inflammatory disease has been updated by many mechanisms such as hypercholesterolemia, dysfunction of endothelial cells, oxidation of lipoproteins and espe‐ cially oxidative stress. In particular, the endothelium is responsible for the...

260p lyly_5 22-03-2013 61 11   Download

Senescence is a biological process that causes a progressive deterioration of structure and function of all organs chronologically. Recent studies have revealed the detailed molecular mechanisms of senescence using cell culture system and experimental organisms. It is thought that senescence is a potential cause for the development of various age-related disorders such as cancer, cardiovascular and neurodegenerative disorders.

158p japet75 25-02-2013 67 6   Download

The vascular endothelium is exposed to an array of physical forces, includ-ing shear stress via blood flow, contact with other cells such as neighboring endothelial cells and leukocytes, and contact with the basement membrane. Endothelial cell morphology, protein expression, stiffness and cytoskeletal arrangement are all influenced by these mechanochemical forces.

14p mobifone23 18-01-2013 38 2   Download

Arterial CO2 tension is a powerful modulator of cerebral vascular calibre, CBF and ICP (12-15.) While the mechanisms are incompletely understood, CO2 relaxes pial arterioles by interactions between the endothelium, vascular smooth muscle, pericytes, adjacent neurons and glial cells. Studies supported that cerebral vessels are sensitive to changes in extracellular pH, rather than a direct response to CO2 or bicarbonate. In the limits of physiological PaCO2, 20-60 mmHg, the relationship between PaCO2 and CBF is linear.

234p wqwqwqwqwq 21-07-2012 80 13   Download

Reactive oxygen species (ROS) were shown to mediate aberrant contractility in hypertension, yet the physiological roles of ROS in vascular smooth muscle contraction have remained elusive. This study aimed to examine whether ROS regulate a1-adrenoceptor-activated contraction by altering myosin phosphatase activities. Methods: Using endothelium-denuded rat tail artery (RTA) strips, effects of anti-oxidants on isometric force, ROS production, phosphorylation of the 20-kDa myosin light chain (MLC20), and myosin phosphatase stimulated by a1-adrenoceptor agonist phenylephrine were examined.

10p toshiba23 18-11-2011 50 2   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis...

12p thulanh13 14-10-2011 49 1   Download

Other Organ Systems and the Future The use of stem cells in regenerative medicine has been studied for many other organ systems and cell types, including skin, eye, cartilage, bone, kidney, lung, endometrium, vascular endothelium, smooth muscle, striated muscle, and others. In fact, the potential for stem cell regeneration of damaged organs and tissues is virtually limitless. However, numerous obstacles must be overcome before stem cell therapies can become a widespread clinical reality.

5p konheokonmummim 03-12-2010 115 8   Download