![](images/graphics/blank.gif)
Therapeutic activity
-
Hepatocellular carcinoma (HCC) is highly malignant with a dismal prognosis, although the available therapies are insufficient. No efficient ubiquitinase has been identified as a therapeutic target for HCC despite the complicating role that of proteins ubiquitination plays in the malignant development of HCC.
14p
vishanshan
27-06-2024
2
1
Download
-
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. Acquired functional mutations in the tyrosine-protein kinase growth factor receptor proto-oncogene (KIT) and platelet-derived growth factor-alpha gene lead to increased tyrosine kinase activity, which is considered a key factor in the pathogenesis of GIST.
14p
vikoch
27-06-2024
1
1
Download
-
Breast carcinoma (BC) ranks as a predominant malignancy and constitutes the second principal cause of mortality among women globally. Epirubicin stands as the drug of choice for BC therapeutics. Nevertheless, the emergence of chemoresistance has significantly curtailed its therapeutic efficacy.
13p
vikoch
27-06-2024
3
1
Download
-
Ebook "Small molecule therapeutics for schizophrenia" covers all relevant aspects of drug research, e.g.
327p
tracanhphuonghoa1007
22-04-2024
3
3
Download
-
Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding the time course of molecular changes responsible for the development of acquired resistance could enable optimization of patients’ treatment options.
22p
vibransone
28-03-2024
3
2
Download
-
Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy characterized by tumor heterogeneity, locoregional metastases, and resistance to existing treatments. Although a number of genomic and molecular alterations associated with HNSCC have been identified, they have had limited impact on the clinical management of this disease.
18p
vibransone
28-03-2024
9
2
Download
-
Recent work has reported that the activation of the p53 pathway in primary cells hampers the efficiency of genome editing by CRISPR/Cas9 via induction of apoptosis or cell cycle arrest. These findings highlight the importance of wholly comprehending cellular responses to programmable nucleases in therapeutically relevant cell types to fulfill the promise of genome editing for therapeutic applications for human diseases.
4p
vibransone
28-03-2024
5
2
Download
-
Small cell lung cancer (SCLC) is a more aggressive subtype of lung cancer that often results in rapid tumor growth, early metastasis, and acquired therapeutic resistance. Consequently, such phenotypical characteristics of SCLC set limitations on viable procedural options, making it difficult to develop both screenings and effective treatments.
20p
vibransone
28-03-2024
3
2
Download
-
Next-generation sequencing (NGS) of cancer gene panels are widely applied to enable personalized cancer therapy and to identify novel oncogenic mutations. Methods: We performed targeted NGS on 932 clinical cases of non-small-cell lung cancers (NSCLCs) using the Ion AmpliSeq™ Cancer Hotspot panel v2 assay.
11p
vioraclene
31-03-2024
3
2
Download
-
Cancer patients often show no or only modest benefit from a given therapy. This major problem in oncology is generally attributed to the lack of specific predictive biomarkers, yet a global measure of cancer cell activity may support a comprehensive mechanistic understanding of therapy efficacy. We reasoned that network analysis of omic data could help to achieve this goal.
12p
vioraclene
31-03-2024
3
1
Download
-
Ebook "Handbook of gas sensor materials (Properties, advantages and shortcomings for applications - Volume 2: New trends and technologies)" provide a detailed and comprehensive account of materials for gas sensors, including the properties and relative advantages of various materials. Since these sensors can be applied for the automation of myriad industrial processes, as well as for everyday monitoring of such activities as public safety, engine performance, medical therapeutics, and in many other situations, this handbook is of great value.
453p
tudohanhtau1006
29-03-2024
4
1
Download
-
Ebook "Mesenchymal stromal cells: Biology and clinical applications" have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs.
697p
duongthandue0501
28-02-2024
3
1
Download
-
Ebook "Handbook of gas sensor materials: Properties, advantages and shortcomings for applications (Volume 1: Conventional approaches)" provide a detailed and comprehensive account of materials for gas sensors, including the properties and relative advantages of various materials. Since these sensors can be applied for the automation of myriad industrial processes, as well as for everyday monitoring of such activities as public safety, engine performance, medical therapeutics, and in many other situations, this handbook is of great value.
454p
nhanphanguyet
28-01-2024
5
2
Download
-
The globus pallidus internus is the main target for the treatment of dystonia by deep brain stimulation. Unfortunately, for some genetic etiologies, the therapeutic outcome of dystonia is less predictable. In particular, therapeutic outcomes for deep brain stimulation in craniocervical and orolaryngeal dystonia in DYT6-positive patients are poor.
6p
vilazada
31-01-2024
7
2
Download
-
Diabetic mastopathy is a rare breast condition that occurs in women with poorly controlled diabetes and is characterized by hardening of the breast tissue. The purpose of this case report is to provide an overview of the clinical characteristics and therapeutic principles of this rare disease to support front-line physicians in their crucial activity of case identification.
4p
vitiki
30-01-2024
2
2
Download
-
Ebook "Animal lectins: Form, function and clinical applications (Volume 1)" presents up-to-date knowledge of animal lectins. Detailed descriptions on biological activities, tissue and/or subcellular distribution, molecular structure, gene organization, possible functions, clinical applications, lectin-ligand interactions and their intervention for therapeutic purposes are provided.
1122p
tachieuhoa
28-01-2024
8
2
Download
-
Ebook "Anthocyanins and human health: Biomolecular and therapeutic aspects" presents comprehensive coverage of anthocyanins. The text covers the scientific literature and clinical significance of this Flavonoid sub-group, with a special focus on their therapeutic aspects. In focusing on secondary metabolites in plants, this work aims to cover the resulting therapeutic potential for humans by referencing the numerous herbal-derived substances which have been evaluated and the rapidly growing data on the interactions of anthocyanins with the microbiome.
145p
lamquandat
28-12-2023
4
2
Download
-
Ebook "Conquering RAS: From biology to cancer therapy" provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene.
272p
lamquandat
28-12-2023
3
2
Download
-
Ebook "Human T-lymphotropic viruses: Methods and protocols" detailed volume draws attention to other members of the Retrovirus family, namely the Human T-lymphotropic Viruses (HTLVs), featuring the most updated technical information about HTLV determination and the methods to investigate their interaction with the host immune system and interfering pathogens.
221p
lucchinguyen
28-12-2023
6
2
Download
-
The integrated stress response (ISR) facilitates cellular adaptation to unfavorable conditions by reprogramming the cellular response. ISR activation was reported in neurological disorders and solid tumors; however, the function of ISR and its role as a possible therapeutic target in hematological malignancies still remain largely unexplored.
17p
vileonardodavinci
23-12-2023
4
3
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)