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Therapeutic goal
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Cancer patients often show no or only modest benefit from a given therapy. This major problem in oncology is generally attributed to the lack of specific predictive biomarkers, yet a global measure of cancer cell activity may support a comprehensive mechanistic understanding of therapy efficacy. We reasoned that network analysis of omic data could help to achieve this goal.
12p
vioraclene
31-03-2024
3
1
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Part 2 book "Handbook of veterinary pain management" includes content: Glucocorticoids; alternative drugs and novel therapies used to treat pain; factors influencing analgesic drug selection, dose, and routes of drug administration; energy modalities; physical therapy and rehabilitation in dogs; physical examination with emphasis on isolating and detecting pain;.... and other contents.
353p
oursky10
07-12-2023
4
3
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Over the past decade, there has been increasing availability of novel therapeutics with improved tolerability and efficacy for advanced non-small cell lung cancer (NSCLC). The study goals were: to compare the uptake of systemic therapy (ST) before and after the availability of targeted tyrosine kinase inhibitors (TKI) and immunotherapy and to examine the changes in overall survival (OS) over time between younger and older adults with advanced NSCLC.
11p
vischultz
20-10-2023
2
1
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Patients presenting with inoperable colon cancer at first onset (ICF) or at time of relapse (ICR) are considered in unrecoverable. The therapeutic goal for unrecoverable cancer is to prolong overall survival (OS) and maintain a high quality of life (QOL).
7p
visharma
20-10-2023
4
2
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Glycaemia control (GC) remains an important therapeutic goal in critically ill patients. The enhanced Model Predictive Control (eMPC) algorithm, which models the behaviour of blood glucose (BG) and insulin sensitivity in individual ICU patients with variable blood samples, is an effective, clinically proven computer based protocol successfully tested at multiple institutions on medical and surgical patients with different nutritional protocols.
10p
viisaacnewton
25-04-2022
11
1
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Optimizing cardiac stroke volume during major surgery is of interest to many as a therapeutic target to decrease the incidence of postoperative complications. Because dynamic preload indicators are strongly correlated with stroke volume, it is suggested that these indices can be used for goal directed fluid therapy. However, threshold values of these indicators depend on many factors that are influenced by surgery, including opening of the abdomen.
5p
viisaacnewton
26-04-2022
10
1
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Human cancer cell line profiling and drug sensitivity studies provide valuable information about the therapeutic potential of drugs and their possible mechanisms of action. The goal of those studies is to translate the findings from in vitro studies of cancer cell lines into in vivo therapeutic relevance and, eventually, patients’ care.
18p
vilichoo2711
23-06-2021
22
1
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Therefore, it is necessary to investigate and determine the biological characteristics of phages for practical therapeutic applications and to expand our understanding of phages as alternatives to antibiotics. With the goal of improving treatment and prevention of S. suis infection, we isolated, characterized lytic phage against S. suis strains
7p
trinhthamhodang11
27-04-2021
21
0
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The aim of the present study was to evaluate the therapeutic effect of high-fow nasal cannula (HFNC) oxygen therapy on patients with aspiration pneumonia accompanied by respiratory failure in the post-stroke sequelae stage, with the goal of providing more effective oxygen therapy and improving patient prognosis.
8p
vimichigan2711
26-03-2021
13
2
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Pulmonary exacerbations (PEx) are a major driver of morbidity and mortality in cystic fibrosis and reducing their frequency by extending the time between them is an important therapeutic goal. Although treatment decisions for exacerbations are often made based on dynamic changes in lung function, it is not clear if these changes truly impact future exacerbation risk.
8p
vimaine2711
26-03-2021
7
2
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Remission is arguably the ultimate therapeutic goal in rheumatoid arthritis (RA). Applying modern strategies, clinical remission can be achieved in a substantial number of patients with early RA (ERA). Even in those patients, the number and scope of erosions can increase.
9p
vitennessee2711
02-02-2021
17
2
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Tendon injuries amount to one of the leading causes of career-ending injuries in horses due to the inability for tendon to completely repair and the high reinjury potential. As a result, novel therapeutics are necessary to improve repair with the goal of decreasing leg lameness and potential reinjury.
11p
vimariana2711
22-12-2020
7
1
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Cancer stem cells (CSCs) are considered the cell subpopulation responsible for breast cancer (BC) initiation, growth, and relapse. CSCs are identified as self-renewing and tumor-initiating cells, conferring resistance to chemo- and radio-therapy to several neoplasias. Nowadays, th (about 10mM)e pharmacological targeting of CSCs is considered an ineludible therapeutic goal.
17p
vialabama2711
21-09-2020
11
0
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There is increasing evidence supporting the concept of cancer stem cells (CSCs), which are responsible for the initiation, growth and metastasis of tumors. CSCs are thus considered the target for future cancer therapies. To achieve this goal, identifying potential therapeutic targets for CSCs is essential.
11p
viamsterdam
18-09-2020
11
0
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Primary invasive Extramammary Paget’s vulvar disease is a rare tumor that is challenging to control. Wide surgical excision represents the standard treatment approach for Primary invasive Extramammary Paget’s vulvar disease. The goal of the current study was to analyze the appropriate indications of radiotherapy in Primary invasive Extramammary Paget's vulvar disease because they are still controversial.
8p
vimale2711
25-08-2020
10
1
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Functional hand splinting is a common therapeutic intervention for children with neurological conditions. The aim of this study was to investigate the effectiveness of the Cognitive Orientation to daily Occupational Performance (CO-OP) approach over and above conventional functional hand splinting, and in combination with splinting, for children with cerebral palsy or brain injury.
12p
vidublin2711
13-01-2020
21
1
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Surveys can help you gather performance information from a variety of sources. Typically, survey questions are geared to the categories established by in the executive job description, though they could also be tied to goals specified in an annual plan. Such areas might include finance, fundraising, community relations, human resources, program performance, planning, and governance.
126p
thamgiacongdong
02-05-2013
51
9
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Cancer cells develop strong anti-apoptotic signaling pathways and therefore escape many therapeutic regimens. Recognizing this feature of cancer cells, we have focused on two approaches: dis-arming the cancer cell from its anti-apoptotic weaponry [1, 2] and applying strategies aimed at enhancing pro-apoptotic signa-ling pathways selectively in the cancer cell [3]. The first goal has been achieved by developing highly selective Aktstatins [1, 2] that inhibit PKB 100 times better than PKA or PKC.
20p
fptmusic
11-04-2013
31
1
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The potential benefits are large and greatly exceed the expected costs of improved fuel economy. Cutting global average automotive fuel consumption (L/100 km) by 50% (i.e. doubling MPG) would reduce emis- sions of CO2 by over 1 gigatonne (Gt) a year by 2025 and over 2 gigatonnes (Gt) by 2050, and result in savings in annual oil import bills alone worth over USD 300 billion in 2025 and 600 billion in 2050 (based on an oil price of USD 100/bbl). The Initiative proposes several steps and actions to work towards the 50:50 overall goal and each step will achieve some of...
13p
nhacnenzingme
23-03-2013
35
3
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As said above, ADAS supports the driver performing driving tasks. As a result, the use of these systems may increase traffic safety, traffic efficiency and improve the sustainability of the vehicle. Another aspect, comfort, can also be improved by the use of ADAS, however, the focus and goal of ADAS development is usually safety improvement. The implementation of ADAS (or intelligent transportation systems in general) may lead to a fatality decrease of 40%3 . It's pointed out that new systems should be well designed and thoroughly tested before introduction.
275p
nhacnenzingme
23-03-2013
61
5
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