Therapeutic outcomes
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Combination therapy is the primary treatment for unresectable hepatocellular carcinoma (u-HCC). The hepatic functional reserve is also critical in the treatment of HCC. In this study, u-HCC was treated with combined hepatic arterial infusion chemotherapy (HAIC), tyrosine kinase inhibitors (TKIs), and programmed cell death protein-1 (PD-1) inhibitors to analyze the therapeutic response, progression-free survival (PFS), and safety.
10p vishanshan 27-06-2024 2 1 Download
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Brain metastasis is a common outcome in non-small cell lung cancer, and despite aggressive treatment, its clinical outcome is still frustrating. In recent years, immunotherapy has been developing rapidly, however, its therapeutic outcomes for primary lung cancer and brain metastases are not the same, suggesting that there may be differences in the immune microenvironment of primary lung cancer and brain metastases, however, we currently know little about these differences.
15p vikoch 27-06-2024 2 1 Download
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Despite some therapeutic advances, improvement in survival rates of unresectable and/or metastatic pancreatic ductal adenocarcinoma (PDAC) has been minimal over recent decade. We aimed to evaluate the impact of different treatment sequences on clinical outcomes of advanced PDAC at our academic institution.
11p vikoch 27-06-2024 1 1 Download
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Ebook Pharmacotherapy handbook, tenth edition delivers the essential information students and practitioners need to quickly and confidently make drug therapy decisions for more than 140 of the diseases and disorders most commonly encountered in a clinical setting. Featuring a convenient alphabetized presentation, this handy guide utilizes text, tables, figures, and treatment algorithms to make important drug data readily accessible and easily understood.
1304p vimeyers 29-05-2024 3 2 Download
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Sensory disturbance is a common symptom of post-stroke. In traditional Chinese medicine (TCM), this symptom is classified as numbness (Ma Mu). While there have been many studies on the therapeutic effect of numbness in TCM, little research has been conducted on the characteristics of numbness. This study aimed to investigate the characteristics of numbness in patients with ischemic stroke in the early rehabilitation phase.
13p viohoyo 25-04-2024 3 1 Download
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Ebook "Oxidative stress in cancer biology and therapy" in order to stimulate the discussion of how the knowledge gained in the emerging field of oxidative stress in cancer biology can be utilized to more effectively design interventions to enhance therapeutic responses while causing fewer treatment limiting complications.
465p tracanhphuonghoa1007 22-04-2024 2 2 Download
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Personalized therapy provides the best outcome of cancer care and its implementation in the clinic has been greatly facilitated by recent convergence of enormous progress in basic cancer research, rapid advancement of new tumor profiling technologies, and an expanding compendium of targeted cancer therapeutics.
20p vioraclene 31-03-2024 2 2 Download
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Prognosis evaluation of advanced breast cancer and therapeutic strategy are mostly based on clinical features of advanced disease and molecular profiling of the primary tumor. Very few studies have evaluated the impact of metastatic subtyping during the initial metastatic event in a prospective study.
15p vibransone 28-03-2024 7 2 Download
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High-grade serous tubo-ovarian cancer (HGSTOC) is characterised by extensive inter- and intratumour heterogeneity, resulting in persistent therapeutic resistance and poor disease outcome. Molecular subtype classification based on bulk RNA sequencing facilitates a more accurate characterisation of this heterogeneity, but the lack of strong prognostic or predictive correlations with these subtypes currently hinders their clinical implementation.
30p vibransone 28-03-2024 6 2 Download
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While understanding molecular heterogeneity across patients underpins precision oncology, there is increasing appreciation for taking intra-tumor heterogeneity into account. Based on large-scale analysis of cancer omics datasets, we highlight the importance of intra-tumor transcriptomic heterogeneity (ITTH) for predicting clinical outcomes.
14p vibransone 28-03-2024 4 2 Download
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Diffuse pleural mesothelioma (DPM) is an aggressive malignancy that, despite recent treatment advances, has unacceptably poor outcomes. Therapeutic research in DPM is inhibited by a paucity of preclinical models that faithfully recapitulate the human disease.
19p viellison 28-03-2024 3 2 Download
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Part 1 book "Basic concepts of psychiatric mental health nursing" includes content: Self awareness; history and trends in psychiatric mental health nursing; development of psychiatric mental health nursing theory; spiritual, cultural, and ethnic issues; ethical and legal issues; forensic nursing practice; loss, grief, and end of life care; continuum of care; aassessment of psychiatric mental health clients; nursing diagnosis, outcome identification, planning, implementation, and evaluation; therapeutic communication and relationships; the therapeutic milieu,... and other contents.
342p muasambanhan08 01-03-2024 6 1 Download
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Novel immunotherapy combination therapies have improved outcomes for patients with hepatocellular carcinoma (HCC), but responses are limited to a subset of patients. Little is known about the inter- and intra-tumor heterogeneity in cellular signaling networks within the HCC tumor microenvironment (TME) that underlie responses to modern systemic therapy.
14p vicwell 29-02-2024 6 2 Download
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The globus pallidus internus is the main target for the treatment of dystonia by deep brain stimulation. Unfortunately, for some genetic etiologies, the therapeutic outcome of dystonia is less predictable. In particular, therapeutic outcomes for deep brain stimulation in craniocervical and orolaryngeal dystonia in DYT6-positive patients are poor.
6p vilazada 31-01-2024 7 2 Download
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Subcutaneous low molecular weight heparin is a commonly used anticoagulant. Catastrophic hemorrhage is a known adverse outcome associated with anticoagulant use. Of all potential bleeding sites, hemorrhage into the rectus sheath is a rare and unusual complication.
4p vitiki 30-01-2024 5 2 Download
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Since the identification of multiple therapeutic targets, as is the case of anaplastic lymphoma kinase (ALK) translocation, the paradigm of treating patients with non-small cell lung cancer (NSCLC) has improved. In order to guarantee the possibility of longer survival outcomes with a better quality of life we must invest in the determination, in suitable time, of the consensual biomarkers and in the availability of the best treatments to our patients.
5p vitiki 30-01-2024 8 3 Download
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LncRNA N6-methylandenosine (m6A) modification has been shown to be associated with the constitution of the tumor microenvironment (TME) and tumorigenesis. It’s essential to understand the mechanisms of lncRNA m6A modification in hepatocellular carcinoma (HCC) and identify relative prognostic predictors to guide therapy and explore potential therapeutic targets. Pearson correlation analysis was performed to identify m6A-related lncRNAs in 374 patients with HCC.
18p vimichaelfaraday 28-12-2023 3 3 Download
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KRAS-mutated non-small cell lung cancer (NSCLC) accounts for 23–35% and 13–20% of all NSCLCs in white patients and East Asians, respectively, and is therefore regarded as a major therapeutic target. However, its epidemiology and clinical characteristics have not been fully elucidated because of its wide variety of mutational subtypes.
9p vileonardodavinci 23-12-2023 5 2 Download
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Immune checkpoint inhibitors, including PD-L1 (programmed death ligand-1) inhibitors have well documented anticancer therapeutic effects in most types of cancers but its use in the treatment of ovarian cancer is not yet proven. The aim of our study is to explore the predictive biomarkers in ovarian cancer and its association with the outcomes.
16p vileonardodavinci 23-12-2023 4 2 Download
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Recurrent/ metastatic squamous cell carcinoma of head and neck (R/M SCCNH) is still a difficult-totreat disease with poor clinical outcomes and limited treatment choices. In view of locoregional recurrent versus dis‑ tant metastatic SCCHN, the therapeutic efcacy of cetuximab-containing regimen and relevant prognostic factors for these two groups may be different.
10p vileonardodavinci 23-12-2023 4 2 Download