Therapeutic proteins

Modulation of DNA damage repair in lung squamous cell carcinoma (LUSC) can result in the generation of neoantigens and heightened immunogenicity. Therefore, understanding DNA damage repair mechanisms holds significant clinical relevance for identifying targets for immunotherapy and devising therapeutic strategies.

15p vishanshan 27-06-2024 1 1   Download

Hepatocellular carcinoma (HCC) is highly malignant with a dismal prognosis, although the available therapies are insufficient. No efficient ubiquitinase has been identified as a therapeutic target for HCC despite the complicating role that of proteins ubiquitination plays in the malignant development of HCC.

14p vishanshan 27-06-2024 1 1   Download

Combination therapy is the primary treatment for unresectable hepatocellular carcinoma (u-HCC). The hepatic functional reserve is also critical in the treatment of HCC. In this study, u-HCC was treated with combined hepatic arterial infusion chemotherapy (HAIC), tyrosine kinase inhibitors (TKIs), and programmed cell death protein-1 (PD-1) inhibitors to analyze the therapeutic response, progression-free survival (PFS), and safety.

10p vishanshan 27-06-2024 2 1   Download

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. Acquired functional mutations in the tyrosine-protein kinase growth factor receptor proto-oncogene (KIT) and platelet-derived growth factor-alpha gene lead to increased tyrosine kinase activity, which is considered a key factor in the pathogenesis of GIST.

14p vikoch 27-06-2024 1 1   Download

Glioblastoma (GBM) is an aggressive brain tumor that exhibits resistance to current treatment, making the identification of novel therapeutic targets essential. In this context, cellular prion protein (PrPC ) stands out as a potential candidate for new therapies.

17p vikoch 27-06-2024 1 1   Download

This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development.

339p vimeyers 29-05-2024 4 2   Download

Ebook "Forkhead transcription factors: Vital elements in biology and medicine" provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in multiple systems throughout the body. Leading international authorities provide their knowledge and insights to offer a novel perspective for translational medicine that highlights the role of forkhead genes and proteins that may have the greatest impact for the development of new strategies for a broad array of disorders.

283p ladongphongthanh1008 22-04-2024 3 2   Download

Ebook "Current topics in complement II" to discuss recent advances in this rapidly-evolving field. This volume represents a collection of topics on the “novel” functions of complement, pathophysiology, protein structures, and complement therapeutics discussed during the conference.

333p ladongphongthanh1008 22-04-2024 3 1   Download

Ebook "Heat shock proteins and plants" provides the most up-to-date and concise reviews and progress on the role of heat shock proteins in plant biology, structure and function and is subdivided into chapters focused on Small Plant HSPs (Part I), Larger Plant HSPs (Part II) and HSPs for Therapeutic Gain (Part III).

341p tracanhphuonghoa1007 22-04-2024 2 2   Download

Ebook "Breast cancer chemosensitivity" include in-depth discussions on multidrug resistance by P-glycoprotein and the multidrug resistance protein family, resistance to therapeutic agent-induced apoptosis, cell cycle deregulation, deregulation of DNA repair, loss of tumor suppressor genes, integrin-mediated adhesion, insulin-like growth factors, epidermal growth factor, and ErbB2 in modulating breast cancer response to systemic therapy, especially, certain chemotherapeutic agents.

187p tracanhphuonghoa1007 22-04-2024 3 1   Download

Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding the time course of molecular changes responsible for the development of acquired resistance could enable optimization of patients’ treatment options.

22p vibransone 28-03-2024 3 2   Download

The number of druggable tumor-specific molecular aberrations has grown substantially in the past decade, with a significant survival benefit obtained from biomarker matching therapies in several cancer types. Molecular pathology has therefore become fundamental not only to inform on tumor diagnosis and prognosis but also to drive therapeutic decisions in daily practice.

19p vibransone 28-03-2024 2 2   Download

Heat shock proteins (HSPs), a representative family of chaperone genes, play crucial roles in malignant progression and are pursued as attractive anti-cancer therapeutic targets. Despite tremendous efforts to develop anti-cancer drugs based on HSPs, no HSP inhibitors have thus far reached the milestone of FDA approval.

16p vibransone 28-03-2024 3 2   Download

Medulloblastoma (MB) is the most common malignant paediatric brain tumour and a leading cause of cancer-related mortality and morbidity. Existing treatment protocols are aggressive in nature resulting in significant neurological, intellectual and physical disabilities for the children undergoing treatment. Thus, there is an urgent need for improved, targeted therapies that minimize these harmful side effects.

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Although anti-apoptotic proteins of the B-cell lymphoma-2 (BCL2) family have been utilized as therapeutic targets in acute myeloid leukaemia (AML), their complicated regulatory networks make individualized therapy difficult.

13p viellison 28-03-2024 2 2   Download

In ebook "Nucleic acid drugs (Advances in Polymer science, Volume 249)" the basic concept of antisense and siRNA strategies is summarized by Dr. Yano of Nippon Shinyaku Co. The antisense strategy can be regarded as the striking NAD concept that was logically innovated in the mid-1970s. Originally, oligonucleotides complementary to mRNAs were thought to physically block translational steps in gene expression resulting in the blocking of protein synthesis.

189p coduathanh1122 27-03-2024 1 1   Download

Ebook "Characterization of protein therapeutics using mass spectrometry" highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity, selectivity, and specificity.

408p coduathanh1122 27-03-2024 2 1   Download

Ebook "Future trends in biotechnology (Advances in Biochemical engineering/biotechnology, Volume 131)" provides readers with contents including: systems metabolic engineering - the creation of microbial cell factories by rational metabolic design and evolution; impacts of quorum sensing on microbial metabolism and human health; CHO glycosylation mutants as potential host cells to produce therapeutic proteins with enhanced efficacy;...

175p coduathanh1122 27-03-2024 2 1   Download

Ebook "Field-flow fractionation in biopolymer analysis" collection of important biomedical applications for a set of separation/characterization techniques that are rapidly gaining popularity due to their wide dynamic range, high resolution, and ability to function in most commonly used solvent systems. Importantly, the field-flow fractionation (FFF) technique has recently emerged as a prominent complement to size exclusion chromatography for protein pharmaceuticals.

306p coduathanh1122 27-03-2024 9 1   Download

The proteome is a major source of therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) study to identify candidate protein markers and therapeutic targets for colorectal cancer (CRC).

13p vicwell 29-02-2024 2 1   Download