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Therapeutic treatment
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Nowadays, different therapeutic options are available for the first-line treatment of metastatic renal cell carcinoma (mRCC). Immuno-combinations are the standard first-line therapy in all mRCC patients regardless of the International Metastatic RCC Database Consortium (IMDC) risk category, even though TKI monotherapy is still a therapeutic option in selected patients.
5p
vishanshan
27-06-2024
1
1
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With the increasing of novel therapeutics for the treatment of Biliary Tract Cancers (BTC), and the need to assess their socio-economic impacts for national licence approvals, it is as important as ever to have real-life data in national populations.
10p
vishanshan
27-06-2024
1
1
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Leptomeningeal metastasis (LM) of small cell lung cancer (SCLC) is a highly detrimental occurrence associated with severe neurological disorders, lacking effective treatment currently. Proteolysis-targeting chimeric molecules (PROTACs) may provide new therapeutic avenues for treatment of podophyllotoxin derivatives-resistant SCLC with LM, warranting further exploration.
12p
vishanshan
27-06-2024
2
1
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One-third of diffuse large B-cell lymphoma (DLBCL) patients suffer relapse after standard treatment. Eukaryotic initiation factor 3a (eIF3a) is a key player in the initial stage of translation, which has been widely reported to be correlated with tumorigenesis and therapeutic response. This study aimed to explore the biological role of eIF3a, evaluate its prognostic and therapeutic potential in DLBCL.
16p
vishanshan
27-06-2024
2
1
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Biliary tract cancer (BTC) is a relatively rare but aggressive gastrointestinal cancer with a high mortality rate. Cancer stem cell (CSC) populations play crucial roles in tumor biology and are responsible for the low response to anti-cancer treatment and the high recurrence rate. This study investigated the role of Transgelin-2 (TAGLN2), overexpressed in CSC in BTC cells, and analyzed its expression in patient tissues and serum to identify potential new targets for BTC.
15p
vishanshan
27-06-2024
1
1
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Endostar, an anti-angiogenic drug, has been approved for treating non-small cell lung cancer (NSCLC). At present, endostar combined with radiotherapy or chemotherapy has achieved ideal results in the treatment of some tumors, but there is a lack of application and study in NSCLC. This study investigated the therapeutic effect and potential mechanism of endostar combined with cisplatin (EC) in NSCLC.
16p
vishanshan
27-06-2024
1
1
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Combination therapy is the primary treatment for unresectable hepatocellular carcinoma (u-HCC). The hepatic functional reserve is also critical in the treatment of HCC. In this study, u-HCC was treated with combined hepatic arterial infusion chemotherapy (HAIC), tyrosine kinase inhibitors (TKIs), and programmed cell death protein-1 (PD-1) inhibitors to analyze the therapeutic response, progression-free survival (PFS), and safety.
10p
vishanshan
27-06-2024
2
1
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The aim of this study was to compare the therapeutic value and treatment-related complications of radical hysterectomy with those of concurrent chemoradiotherapy (CCRT) for locally resectable (T1a2–T2a1) stage IIIC1r cervical cancer.
6p
vikoch
27-06-2024
1
1
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Glioblastoma (GBM) is an aggressive brain tumor that exhibits resistance to current treatment, making the identification of novel therapeutic targets essential. In this context, cellular prion protein (PrPC ) stands out as a potential candidate for new therapies.
17p
vikoch
27-06-2024
2
1
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Brain metastasis is a common outcome in non-small cell lung cancer, and despite aggressive treatment, its clinical outcome is still frustrating. In recent years, immunotherapy has been developing rapidly, however, its therapeutic outcomes for primary lung cancer and brain metastases are not the same, suggesting that there may be differences in the immune microenvironment of primary lung cancer and brain metastases, however, we currently know little about these differences.
15p
vikoch
27-06-2024
2
1
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Predicting tumor responses to neoadjuvant chemotherapy (NAC) is critical for evaluating prognosis and designing treatment strategies for patients with breast cancer; however, there are no reliable biomarkers that can effectively assess tumor responses. Therefore, we aimed to evaluate the clinical feasibility of using extracellular vesicles (EVs) to predict tumor response after NAC.
12p
vikoch
27-06-2024
1
1
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Despite some therapeutic advances, improvement in survival rates of unresectable and/or metastatic pancreatic ductal adenocarcinoma (PDAC) has been minimal over recent decade. We aimed to evaluate the impact of different treatment sequences on clinical outcomes of advanced PDAC at our academic institution.
11p
vikoch
27-06-2024
1
1
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Tacrolimus, a calcineurin inhibitor, is a first-choice drug for the anti-rejection treatment regimen after kidney transplantation. The daily adjusted Tacrolimus dose by therapeutic drug monitoring is essential for patients to achieve optimal effects and minimize complications.
9p
visergeyne
18-06-2024
1
0
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Prevention, diagnosis and treatment are the watchwords in stroke research, for basic neuroscientists and clinicians alike. This 2002 book, from the 22nd Princeton Conference on Cerebrovascular Disease, contains contributions from outstanding investigators on numerous topics in stroke research. The contents cover the status and future directions of stroke pathophysiology, diagnosis and treatment, with special emphasis on the molecular and cellular mechanisms of ischaemic cell death and repair, and clinical issues including imaging, risk factors and therapeutic strategies in stroke.
456p
vimeyers
29-05-2024
4
2
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Dr. Richard Polin’s Neonatology Questions and Controversies series highlights the most challenging aspects of neonatal care, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today’s practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient.
452p
vimeyers
29-05-2024
2
2
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Ebook Pharmacotherapy handbook, tenth edition delivers the essential information students and practitioners need to quickly and confidently make drug therapy decisions for more than 140 of the diseases and disorders most commonly encountered in a clinical setting. Featuring a convenient alphabetized presentation, this handy guide utilizes text, tables, figures, and treatment algorithms to make important drug data readily accessible and easily understood.
1304p
vimeyers
29-05-2024
3
2
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Established for more than 75 years, Ebook The Washington manual of medical therapeutics, 36th edition, provides concise, high-yield content that reflects today’s fast-changing advances in medical technology and therapeutics. In one convenient, portable resource, you’ll find complete coverage of every area of medicine and the core subspecialties—all at your fingertips for quick review and reference. Discover why housestaff and faculty worldwide depend on this best-selling resource for day-to-day clinical practice in internal medicine.
3623p
vimeyers
29-05-2024
4
2
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Pluchea pteropoda, an annual plant in the Asteraceae family, has traditionally been used in Vietnamese folk medicine as an alternative treatment for high fever, indigestion, and painful and swollen wounds. The present study investigates the acute toxicity and antiinflammatory effects of P. pteropoda aerial parts ethanol extract (EtPP) in animal models. EtPP exhibited no toxicity in mice with a single dose of up to 5000 mg/kg.
5p
vicarlos
16-05-2024
0
0
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Ebook "Oxidative stress in cancer biology and therapy" in order to stimulate the discussion of how the knowledge gained in the emerging field of oxidative stress in cancer biology can be utilized to more effectively design interventions to enhance therapeutic responses while causing fewer treatment limiting complications.
465p
tracanhphuonghoa1007
22-04-2024
2
2
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Psychosocial and educational intervention approaches employ diverse treatment frameworks, most of which involve delivering some form of feedback to participants about their behavior. General conceptions of feedback are well-known to underlie mainstream therapeutic and educational approaches. Recently emerging ‘smart’ approaches also rely on feedback principles.
13p
viarnault
25-04-2024
4
2
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