Thereby pathogenesis

Breast cancer (BC) is a prevalent disease that harms women’s health, and in-depth investigations of the pathogenesis, treatment, and prevention of BC are the focus of many research programs. Chidamide (CHI) is a histone deacetylase suppressor that depresses histone deacetylase functions, thereby influencing cell growth through an epigenetic mechanism.

10p vischultz 20-10-2023 2 1   Download

Major trauma patients (TP) developing imbalanced immune response are at high risk for infectious post-injury complications including pneumonia. Neutrophils play a central role in the host defense against bacteria and thereby pathogenesis of infections.

10p vimaine2711 26-03-2021 7 2   Download

The ‘‘sunshine’’ vitamin is a hot topic that attracted ample attention over the past decades, specially that a considerable proportion of the worldwide population are deficient in this essential nutrient. Vitamin D was primarily acknowledged for its importance in bone formation, however; increasing evidence point to its interference with the proper function of nearly every tissue in our bodies including brain, heart, muscles, immune system and skin.

12p trinhthamhodang1 16-11-2019 30 2   Download

Uric acid is a key product of the metabolism of purines, the backbone of Desoxyribonucleic acid (DNA). Being a fundamental component of every living cell, the total Earth’s DNA base pairs is estimated to weigh 50 billion tons [1], which translates into a huge abundance of uric acid in our planet. It would be naive to think of all these virtual heaps of uric acid as useless, inert waste produces. Indeed, they are not. Uric acid in the environment is a rich source of nitrogen (33% of its weight) to plant life, hence its important role in the universal food chain.

4p trinhthamhodang1 14-11-2019 13 0   Download

Since the global financial crisis began in 2007, there has been a lot of hand-wringing about the independence of central banks. Some commentators today would suggest that the recent large scale purchases of government bonds by central banks inherently represent a compromise of their independence from elected officials. Others will assert that the central banks which purchased private-sector securities, thereby jeopardizing their balance sheets and supposedly making political asset allocations, are the ones which have put their independence at risk.

0p taisaocothedung 12-01-2013 50 4   Download

Model systems are important tools for the investigation of pathogenic processes. Especially for diseases with a late onset of symptoms and slow progression, like most spinocerebellar ataxias (SCA), it is time-consuming or even impossible to analyze all aspects of the pathogenesis in humans.

206p hotmoingay 03-01-2013 41 3   Download

A cholesterol-rich diet causes postprandial hyperlipaemia with an accumulation of chylomicrons. This accumulation leads to a redistribution of the very-low-density lipoproteins (VLDL), thereby determining the elimination of the coarsest particles, the residual chylomicrons, which promote the onset of atherogenesis [1]. For some years, cholesterol-rich food has been associated with the subsequent development of complications such as the formation of atheromatous plaque and lipid deposits at the ocular level.

194p xunu1311 02-11-2012 48 1   Download

Therefore, the brain hormonal milieu in which exogenous hormones are introduced is markedly different in menopause from that in menstruating women. In the ovariectomized animals, however, the hormonal changes in the animals are abrupt in contrast to the gradual hormonal changes found in the menopausal transition. It might be the concerted lack of estradiol and progesterone that facilitate the seizure susceptibility. Both estradiol and progesterone affect γ-amino butyric acid (GABA) ergic function (Scharfman et al, 2005; Nakumura et al, 2005; Kokate et al, 1994).

228p ti_du_hoang 15-08-2012 64 15   Download