Thioredoxin 1

There is a long-time unmet need for a means to detect breast cancer (BC) using blood. Although mammography is accepted as the gold standard for screening, a blood-based diagnostic can complement mammography and assist in the accurate detection of BC in the diagnostic process period of early diagnosis. We have previously reported the possible use of thioredoxin 1 (Trx1) in serum as a novel means to detect BC.

14p vielonmusk 21-01-2022 16 1   Download

Themosquito,Anopheles gambiae, is an important vector of Plasmodium falciparum malaria. Full genome analysis revealed that, as in Drosophila melanogaster,the enzyme glutathione reductase is absent inA. gambiaeand func-tionally substituted by the thioredoxin system. The key enzyme of this system is thioredoxin reductase-1, a homo-dimeric FAD-containing protein of 55.3 kDa per subunit, which catalyses the reaction NADPH + H + + thio-redoxin disulfidefiNADP + + thioredoxin dithiol.

10p tumor12 20-04-2013 31 3   Download

Observations of thioredoxin inhibition by cadmium and of a positive role for thioredoxin in protection from Cd 2+ led us to investigate the thioredoxin–cadmium interaction properties.We used calorimetric and spectroscopicmethods at different pHvalues to explore the relative contribution of putative binding residues (Cys32, Cys35, Trp28, Trp31 and Asp26) within or near the active site. At pH 8 or 7.5 two binding sites were identified by isothermal titration calorimetry with affinity constants of 10·10 6 M )1 and 1·10 6 M )1 . ...

11p dell39 03-04-2013 39 4   Download

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Altered expression of thioredoxin reductase-1 in dysplastic bile ducts and cholangiocarcinoma in a hamster model

6p hoami_266 16-09-2011 42 4   Download