Thiourea derivatives
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Ebook "Development of novel hydrogen-bond donor catalysts" describes novel, effective hydrogen-bond (HB) donor catalysts based on a known bifunctional tertiary amine-thiourea, a privileged structure, which has been proven to be one of the most widely used organocatalysts. These HB donor catalysts derived from quinazoline and benzothiadiazine were initially synthesized as novel HB donors with their HB-donating abilities being measured by analytical methods.
119p coduathanh1122 27-03-2024 1 1 Download
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Cu9S5 nanocrystals were synthesized from unsymmetrical [(Hex)(Me)NC(S)NC(O)C6H3(NO2)2-3,5]2Cu(II) and [(Et)(Bu)NC(S)NC(O)C6H4-4-NO2]2Cu(II) complexes by colloidal thermolysis in the presence of surfactant oleylamine. The unsymmetrical copper complexes were synthesized by the reaction of copper(II) acetate with N-[hexyl(methyl)carbamothioyl]-3,5-dinitrobenzamide and N-[ethyl(butyl)carbamothioyl]-4-nitrobenzamide. The complexes were used as single-source precursors for the preparation of Cu9S5 nanocrsytals.
10p langthannam 29-12-2021 8 0 Download
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1-(Benzothiazol-2-yl)-3-phenylthiourea 2 was prepared and treated with hydrazonoyl chlorides 3a–e to yield the corresponding 5-(benzothiazol-2-ylimino)-1,3,4-thiadiazole derivatives 6a–e, respectively. Reaction of the thiourea derivative 2 with ethyl 2-chloro-3-oxobutanoate 9 afforded the corresponding 2-(benzothiazol-2-ylimino)thiazole5-carboxylate derivative 11. The newly synthesized heterocyclic derivatives were confirmed from their elemental and spectral analyses.
6p langthannam 29-12-2021 5 0 Download
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The latter compounds react also by grinding method with nitrogen nucleophiles such as hydrazine hydrate, phenylhydrazine, and thiosemicarbazide to afford the corresponding pyrazol-3-yl pyrazolines. A series of 6-pyrazolylpyrimidine2-thione derivatives were prepared by reaction of the above chalcones with thiourea by grinding method in the presence of a catalytic amount of sodium hydroxide at room temperature. In addition, 7-pyrazolylpyridopyrimidine-3-thione was prepared by reaction of chalcone with 6-aminothiouracil.
15p langthannam 29-12-2021 6 0 Download
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A novel four component modified Biginelli reaction for the synthesis of C-2 functionalized dihydropyrimidines has been established. The approach uses assembly of less explored acetyl acetone with aromatic aldehyde, thiourea, and dimethyl sulphate to construct a novel 5-acetyl 2-methylthio dihydropyrimidine system, which works as an efficient well-designed intermediate for generating C-2 modified Biginelli libraries with nitrogen nucleophiles.
20p langthannam 29-12-2021 10 0 Download
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A series of novel 2,5-dioxopyrrolidines were synthesized by the one-pot reaction of coumarin-3-carboxylic acids 1 with thiourea derivatives and alkyl isocyanides in the presence of Fe 3 O4 NPs @ lipase as heterogeneous reusable nanobiocatalysts with high yields. Multicomponent reactions (MCRs) are useful tools for the efficient synthesis of heterocyclic compounds due to their environmental friendliness, atomic economy, and green specifications.
12p tudichquannguyet 29-11-2021 12 1 Download
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Twenty-five new hydroxy- and methoxy-substituted 4,6-diarylpyrimidin-2(1H)-ol (20–34) and 4,6-diarylpyrimidine-2(1H)-thiol derivatives (35–44) were synthesized from the reaction of the corresponding 1,3-diaryl-2-propene-1- one compounds (1–19) with urea or thiourea using the solid-phase microwave method. All the new synthetic compounds (20–44) were evaluated with regard to their α-glucosidase activity. However, only compounds 22–25, 27, 31, 34, 35, 37, and 40 exhibited a greater inhibitory effect than standard acarbose. The IC50 values of the active compounds ranged between 2.36 and 13.
16p tudichquannguyet 29-11-2021 9 1 Download
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Pyrimidine derivatives are well known due to their remarkable pharmacological potential in various fields of science, and they are also present in some natural substances like DNA and RNA. These scaffolds manifest diversified biological activities such as antimicrobial, antiinflammatory, anti-HIV, antitubercular, antitumor, antineoplastic, and antimalarial. A pyrimidine ring is constructed when chalcones, amidines, guanidine, nitriles, isocyanates, urea, thiourea, and aminopyrazoles undergo condensation, coupling, or cyclization reactions.
38p tudichquannguyet 29-11-2021 11 1 Download
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The main objective of this work was to synthesize novel compounds with a benzo[de][1,2,4]triazolo[5,1-a]isoquinoline scafold by employing (dioxo-benzo[de]isoquinolin-2-yl) thiourea as a building block. Molecular docking was conducted in the COX-2 active site to predict the plausible binding mode and rationalize the structure–activity relation‑ ship of the synthesized compounds.
14p vijiraiya2711 27-05-2020 15 1 Download
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Many thiourea derivatives have exhibited biological activities including anticancer activity through several mechanisms. On the other hand, benzenesulfonamide derivatives have proven to be good anticancer agents. Hybrids of both moieties could be further developed to explore their biological activity as anticancer.
13p vijiraiya2711 27-05-2020 13 0 Download
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Various thiourea derivatives have been used as starting materials for compounds with better biological activities. Molecular modeling tools are used to explore their mechanism of action.
14p vijiraiya2711 27-05-2020 9 1 Download
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A series of novel N-(2, 6-dimethoxypyrimidin-4-yl)-4-(3-(aryl)thioureido) benzenesulfonamides 3a–t was synthesized by the addition of N-(2,6-dimethoxypyrimidin-4-yl)-4-isothiocyanatobenzenesulfonamide 2 to the appropriate aromatic amine.
12p vijiraiya2711 27-05-2020 12 0 Download
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In this study, the selective oximation of structurally diverse aromatic aldehydes (versus ketones) to the corresponding aldoxime derivatives was investigated using the combination system of NH2OH·HCl and bis-thiourea complexes of cobalt, nickel, copper and zinc chlorides, MII(tu)2Cl2, in a mixture of CH3CN-H2O (1:1).
10p tocectocec 25-05-2020 9 1 Download
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World population is expected to reach 9.7 billion by 2050, which makes a great challenge the achievement of food security. The use of urease inhibitors in agricultural practices has long been explored as one of the strategies to guarantee food supply in enough amounts. This is due to the fact that urea, one of the most used nitrogen (N) fertilizers worldwide, rapidly undergoes urease-driven hydrolysis on soil surface yielding up to 70% N losses to environment.
9p trinhthamhodang1 14-11-2019 11 0 Download
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Some compounds of N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-N-(benzothiazole-2- yl)thioureas have been synthesized from corresponding 2,3,4,6-tetra-O-acetyl--Dglucopyranosyl isothiocyanate and the substituted derivatives of 2-aminobenzothiazoles executing in home microwave oven. Their spectroscopic properties have been recorded and the relationships between their structures and spectral properties (IR, 1 H- and 13C-NMR) have been discussed.
5p giesumanh 13-11-2018 20 0 Download