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Tissue transglutaminase
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Breast cancer (BC) is the most common malignant tumor among women worldwide. Tissue transglutaminase 2 (TG2) has been reported as a major player across several types of cancer. However, the effects of TG2 in breast cancer are less known.
11p
vileonardodavinci
23-12-2023
3
2
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Kaempferol, a natural flavonoid, exhibits anticancer properties by scavenging reactive oxygen species (ROS). However, increasing evidence has demonstrated that, under certain conditions, kaempferol can inhibit tumor growth by upregulating ROS levels.
11p
vianrose2711
27-04-2021
8
1
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Appropriate interpretation of a positive celiac antibody test by an ordering physician is important in order to institute proper management. We evaluated why children with an initial positive celiac serology were not referred for diagnostic biopsy or followed with serial testing by the ordering physician.
6p
virome2711
13-01-2020
15
1
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Celiacdisease isan intestinalmalabsorptioncharacterizedby an intolerance to cereal proteins accompanied by immuno-logical responses to dietary gliadins and an autoantigen located in the endomysium. The latter has been identified as the enzyme tissue transglutaminase which belongs to a family of enzymes that catalyze protein cross-linking reac-tions and is constitutivelyexpressed inmany tissues aswell as being activated during apoptosis.
7p
tumor12
22-04-2013
37
1
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Transglutaminases form a large family of intracellular and extracellular enzymes that catalyse the Ca 2+ -dependent post-translational modification of proteins. Despite significant advances in our understanding of the biolo-gical role of most mammalian transglutaminase isoforms, recent findings suggest new scenarios, most notably for the ubiquitous tissue transglutami-nase.
17p
awards
05-04-2013
42
2
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The multifunctional tissue transglutaminase 2 (TG2) has a four-domain structure with several Ca 2+ -regulated biochemical activities, including transglutamylation and GTP hydrolysis. The structure of the Ca 2+ -binding form of the human enzyme is not known, and its Ca 2+ -binding sites have not been fully characterized.
14p
vinaphone15
25-02-2013
28
1
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Tissue transglutaminase (TG2) is a ubiquitously expressed member of the transglutaminase family of Ca 2+ -dependent crosslinking enzymes. Unlike other family members, TG2 is a multifunctional protein, which has several other well documented enzymatic and non-enzymatic functions.
13p
cosis54
08-12-2012
37
1
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