Tolerance intervals

A Bayesian approach with frequentist validity has been developed to support inferences derived from a BLevel A^ in vivo-in vitro correlation (IVIVC). Irrespective of whether the in vivo data reflect in vivo dissolution or absorption, the IVIVC is typically assessed using a linear regression model. Confidence intervals are generally used to describe the uncertainty around the model. While the confidence intervals can describe population-level variability, it does not address the individual-level variability.

16p caothientrangnguyen 09-05-2020 39 2   Download