Toxicity studies

This study aimed to investigate the acute and subchronic toxicities of “Thong ta yeu phuong” capsules through oral administration in experimental animals. The acute toxicity was determined using the Litchfield Wilcoxon method in mice.

8p vikoch 27-06-2024 2 1   Download

Traditional herbal medicine has been used to prevent and treat various diseases for years. The present study evaluated the potential toxicity of Phatra Tricholes soft capsule after acute and subchronic administration in experimental research.

9p vikoch 27-06-2024 1 1   Download

“Dứa tre Lão nhà quê” extract (DTLNQ extract) was intended to treat several diseases such as dyslipidemia and venous insufficiency. To provide information on the its safety, this study evaluated the subchronic toxicity of DTLNQ extract.

8p vikoch 27-06-2024 2 1   Download

The objective of this study was to describe real-world adjuvant therapy (AT) use by disease substage and assess determinants of treatment choice among patients with stage III melanoma. This non-interventional retrospective study included survey responses and data from patient records pro‑ vided by US medical oncologists.

13p vishanshan 27-06-2024 1 1   Download

Nervous system toxicity (NST) is one of the most frequent and dangerous side effects of chimeric antigen receptor T-cell (CAR-T) therapy, which is an effective treatment for related tumors in most relapsed/refractory (r/r) hematologic malignancies. Current clinical trial data do not fully reflect the real-world situation. Therefore, this study evaluated the NST of CAR-T therapy using the FDA Adverse Event Reporting System (FAERS).

11p vishanshan 27-06-2024 2 1   Download

The ongoing crisis in Syria has divided the country, leading to significant deterioration of the healthcare infrastructure and leaving millions of people struggling with poor socioeconomic conditions. This study aimed to provide insights into how humanitarian assistance can alleviate the financial burdens associated with cancer treatment in conflict-affected regions.

11p vishanshan 27-06-2024 1 1   Download

The prognosis of patients with Relapsed/Refractory Osteosarcoma (R/R OS) remains dismal without an agreement on systemic therapy. The use of High-Dose Ifosfamide (14 g/sqm) with an external pump in outpatient setting (14-IFO) in R/R OS patients is limited. This study represents the first retrospective cohort analysis focused on evaluating the activity and toxicity of 14-IFO in this setting.

12p vikoch 27-06-2024 1 1   Download

Checkpoint inhibitors (CPIs) are widely used in cancer treatment, with transformative impacts on survival. They nonetheless carry a significant risk of toxicity in the form of immune-related adverse events (IrAEs), which may be sustained and life-altering. IrAEs may require high-dose and/or prolonged steroid use and represent a significant healthcare burden.

11p vikoch 27-06-2024 1 1   Download

Definitive concurrent chemoradiotherapy (dCCRT) is the gold standard for the treatment of locally advanced esophageal squamous cell carcinoma (ESCC). In this study, we aim to generate evidence regarding consolidation chemotherapy efficacy in patients with locally advanced, inoperable ESCC.

8p vikoch 27-06-2024 2 1   Download

This study aimed to investigate the levels of contamination of potentially toxic trace elements in the soil of Dong Nai Province, Vietnam. To achieve this, the Instrument Neutron Activation Analysis (INAA) method was employed to measure the concentrations of five potentially toxic trace elements, including manganese (Mn), arsenic (As), chromium (Cr), antimony (Sb), and zinc (Zn), across 30 soil samples collected from the region.

11p visergeyne 18-06-2024 1 0   Download

Toxic metals in water systems pose a global health risk. Thus, multifunctional water monitoring and treatment materials are indispensable. Nickel ions, a frequent heavy metal pollutant, affect ecosystem function. This study investigates the utilization of Al2O3@g-C3N4 (AlCN) nanosorbent for adsorbing Ni (II) ions from aqueous solutions.

9p visergeyne 18-06-2024 0 0   Download

The GLP regulations have developed from rules on how to exactly document the planning, conduct and reporting of toxicity studies to a quality system for the management of a multitude of study types, from the simple determination of a physical/chemical parameter to the most complex field tests or ecotoxicology studies. At the same time the term "Good Laboratory Practice" has become somewhat of a slogan with the aim to characterise any reliably conducted laboratory work.

432p vimeyers 29-05-2024 5 2   Download

The increased exposure to toxins, toxicants and novel drugs has promoted toxicology to become one of the most important areas of research with emerging innovative toxicity testing protocols, techniques, and regulation being placed.

236p vimeyers 29-05-2024 5 2   Download

Ebook "Bioremediation technology: Recent advances" discusses bioremediation technology-based remediation to restore contaminated sites and protect the environment. It studies the opportunities for more efficient biological processes in molecular biology and ecology. Notable accomplishments of these studies include the cleaning up of polluted water and contaminated land. The book includes invited papers by eminent contributors who provide cost-effective bioremediation strategies to immobilize contaminants for cleanup of environment.

391p giangdongdinh 28-05-2024 1 1   Download

Pluchea pteropoda, an annual plant in the Asteraceae family, has traditionally been used in Vietnamese folk medicine as an alternative treatment for high fever, indigestion, and painful and swollen wounds. The present study investigates the acute toxicity and antiinflammatory effects of P. pteropoda aerial parts ethanol extract (EtPP) in animal models. EtPP exhibited no toxicity in mice with a single dose of up to 5000 mg/kg.

5p vicarlos 16-05-2024 0 0   Download

The result pointed out that only 5 g of soft tissue from N. glans (equivalent to 2–3 specimens) containing maximum toxicity detected in the present study may cause human death if consumed. Fhe first time, this study identified TTXs in the gastropods as a causative toxin in the poisoning in Vietnam. Moreover, 65.5% of studied specimens with high toxicity higher than 100 MU/g, including 16.1%, showing extremely high toxicity (> 1,000 MU/g). The results suggested that this gastropod is quite dangerous for human consumption and should be alerted to public awareness.

6p dianmotminh02 03-05-2024 3 1   Download

The present works deals with the preparation of bioadsorbent from the dried mature leaves of Water hyacinth plant (Eichhornia crassipes) that can be used for removal of cationic contaminants, Pb2+ and Cu 2+ from spiked water.

15p dianmotminh02 03-05-2024 2 1   Download

The kinetic study was also carried out by studying the adsorption process at different temperatures using these two adsorbents to find the rate of adsorption process, its mechanism and to determine different thermodynamic parameters. For this purpose, different kinetic models were used which include film diffusion, particle diffusion, intraparticle diffusion, Elovich, Lagergren pseudo first order, Lagergren pseudo second order, simple first order and second order equations.

17p dianmotminh02 03-05-2024 2 1   Download

This study aimed to assess the antimicrobial and antioxidant activities of 61 marine fungal strains isolated from 34 samples collected in the research journey of the Akademik Oparin vessel in the North Sea of Vietnam in 2021. Of these, 23 were from sponges, 21 from seaweeds, 15 from sediments, and only 2 from seawater.

13p dianmotminh02 03-05-2024 2 1   Download

This study, a range of temperatures, lighting periods and salinity levels were examined for cyst hatching. The quality nauplii from optimized cyst hatching conditions were used to determine the toxicity of 26 methanol extracts of 24 poisonous plant species collected from the mountainous regions in Quang Tri province of Vietnam.

13p dianmotminh02 03-05-2024 2 1   Download