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The aim of the study was to enhance colorectal cancer prognostication by integrating single nucleo‑ tide polymorphism (SNP) and gene expression (GE) microarrays for genomic and transcriptional alteration detection; genes with concurrent gains and losses were used to develop a prognostic signature.

13p visusanwojcicki 28-06-2022 11 2   Download

Open chromatin profiling integrates information across diverse regulatory elements to reveal the transcriptionally active genome. Tn5 transposase and DNase I sequencing-based methods prefer native or high cell numbers. Here, we describe NicE-seq (nicking enzyme assisted sequencing) for high-resolution open chromatin profiling on both native and formaldehyde-fixed cells.

15p vialfrednobel 29-01-2022 15 0   Download

The nuclear envelope (NE) that encapsulates the nuclear genome is a double lipid bilayer with several integral and peripherally associated proteins. It is a characteristic feature of the eukaryotes and acts as a hub for a number of important nuclear events including transcription, repair, and regulated gene expression.

13p vitzuyu2711 29-09-2021 13 1   Download

Transcriptional activity of genes depends on many factors like DNA motifs, conformational characteristics of DNA, melting etc. and there are computational approaches for their identification. However, in real applications, the number of predicted, for example, DNA motifs may be considerably large.

11p viwyoming2711 16-12-2020 11 1   Download

Stored biological samples with pathology information and medical records are invaluable resources for translational medical research. However, RNAs extracted from the archived clinical tissues are often substantially degraded.

16p vioklahoma2711 19-11-2020 3 1   Download

Plant transformation via Agrobacterium tumefaciens is characterized by integration of commonly low number of T-DNAs at random positions in the genome.

14p vishikamaru2711 29-04-2020 18 2   Download

Viral diseases are one of the major factors threatening crop production worldwide. It is estimated that about 15 percent of global crop production is lost due to various plant diseases, and phytopathogenic viruses are thought to cause more than one third of plant diseases. Viruses such as TYLCV, PRSV, CMV, BBTV are some major virus epidemics which cause heavy losses in horticultural crops. Management of plant virus diseases have acquired great importance in the realm of Plant Pathology and call for effective management against them.

14p chauchaungayxua3 07-02-2020 11 0   Download