Transcriptional function

Lung adenocarcinoma (LUAD) is a non-small cell carcinoma. Ribonuclease/angiogenin inhibitor 1 (RNH1) exerts multiple roles in virous cancers. E2F1 is a critical transcription factor involved in the LUAD development. Here, we analyze the expression of RNH1 in LUAD patients, investigate the biological function of RNH1 in LUAD, and demonstrate its potential mechanisms through E2F1 in LUAD.

17p vikoch 27-06-2024 1 1   Download

Ebook "Rb and tumorigenesis" examines how recent advances have demonstrated the interaction of Rb with chromatin remodeling enzymes. This new title explores the potential roles of these interactions in Rb functions and provides some evidence that distinct Rb co-repressor may target different genes in different phases of the cell cycle.

129p ladongphongthanh1008 22-04-2024 3 3   Download

Ebook "CtBP family proteins" are unique in several aspects. They were the first among proteins containing a metabolic enzyme fold to be implicated in transcriptional regulation. The vertebrate CtBPs exhibit distinct nuclear and cytosolic activities. The crystal struaures of CtBPl and molecular modeling studies have illuminated the molecular basis of its dual activity and the interaction with target peptides.

131p ladongphongthanh1008 22-04-2024 5 2   Download

Ebook "Molecular and cellular biology of platelet formation: Implications in health and disease" gives a comprehensive insight into platelet biogenesis, platelet signal transduction, involvement of platelets in disease, the use of diverse animal models for platelet research and future perspectives in regard to platelet production and gene therapy. Being written by international experts, the book is a concise state-of-the art work in the field of platelet biogenesis, biology and research.

456p ladongphongthanh1008 22-04-2024 3 2   Download

Ebook "The molecular mechanisms of axenfeld-rieger syndrome" presents detailed information and clinical descriptions and diagnosis of ARS, phenotypical descriptions of patients with ARS, molecular aspects of ARS and gene structure/function studies; describes state-of-the-art scientific methods used to assay genes, gene products and structure/function activities of transcription factors;...

115p tracanhphuonghoa1007 22-04-2024 4 2   Download

Ebook "Ten years of progress in GW/P body research" richly explores these original scienti fi c discoveries and many of the subsequent detailed studies of the components and functions of RNA processing that take place in GW/P bodies. The author list is truly impressive and reading the history will pique the interests of students and senior investigators, and hopefully, provide insights into future directions of the fi eld of RNA biology.

280p tracanhphuonghoa1007 22-04-2024 1 1   Download

Accumulating evidence suggests alternative splicing (AS) is a co-transcriptional splicing process not only controlled by RNA-binding splicing factors, but also mediated by epigenetic regulators, such as chromatin structure, nucleosome density, and histone modification. Aberrant AS plays an important role in regulating various diseases, including cancers.

11p vibransone 28-03-2024 5 2   Download

Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy characterized by tumor heterogeneity, locoregional metastases, and resistance to existing treatments. Although a number of genomic and molecular alterations associated with HNSCC have been identified, they have had limited impact on the clinical management of this disease.

18p vibransone 28-03-2024 9 2   Download

Currently, circRNA studies are shifting from the identification of circular transcripts to understanding their biological functions. However, such endeavors have been limited by large-scale determination of their full-length sequences and also by the inability of accurate quantification at the isoform level.

20p vibransone 28-03-2024 3 2   Download

Current computational methods on Hi-C analysis focused on identifying Mb-size domains often failed to unveil the underlying functional and mechanistic relationship of chromatin structure and gene regulation. We developed a novel computational method HiSIF to identify genome-wide interacting loci.

13p vibransone 28-03-2024 7 2   Download

The mitochondrial genome is transcribed as continuous polycistrons of RNA containing multiple genes. As a consequence, post-transcriptional events are critical for the regulation of gene expression and therefore all aspects of mitochondrial function.

12p vioraclene 31-03-2024 4 2   Download

The bromodomain containing 1 (BRD1) gene has been implicated with transcriptional regulation, brain development, and susceptibility to schizophrenia and bipolar disorder. To advance the understanding of BRD1 and its role in mental disorders, we characterized the protein and chromatin interactions of the BRD1 isoforms, BRD1-S and BRD1-L.

20p vioraclene 31-03-2024 4 1   Download

The heat shock transcriptional response is essential to effective cellular function under stress. This is a highly heritable trait but the nature and extent of inter-individual variation in heat shock response remains unresolved.

13p vioraclene 31-03-2024 2 2   Download

NF-κB is widely involved in lymphoid malignancies; however, the functional roles and specific transcriptomes of NF-κB dimers with distinct subunit compositions have been unclear. Using combined ChIP-sequencing and microarray analyses, we determined the cistromes and target gene signatures of canonical and non-canonical NF-κB species in Hodgkin lymphoma (HL) cells.

16p vioraclene 31-03-2024 9 2   Download

Genome-wide association studies (GWASs) have identified multiple risk loci for bipolar disorder (BD). However, pinpointing functional (or causal) variants in the reported risk loci and elucidating their regulatory mechanisms remain challenging.

20p viellison 28-03-2024 3 2   Download

Ebook "Post-transcriptional regulation by STAR proteins: Control of RNA metabolism in development and disease" reviews the available information on the structure of the RNA binding STAR domain and provides insights into how these proteins discriminate between different RNA targets; Overviews of the post-translational modifications of STAR proteins and their effects on biological functions.

176p cotieubac1004 15-03-2024 3 0   Download

Part 1 book "Molecular cell biology" includes content: Life begins with cells, chemical foundations, protein structure and function, basic molecular genetic mechanisms, biomembranes and cell architecture, integrating cells into tissues, transport of ions and small molecules across cell membranes, cellular energetics, molecular genetic techniques and genomics, molecular structures of genes and chromosomes, transcriptional control of gene expression.

490p muasambanhan07 18-02-2024 2 2   Download

TGF-β-induced factor homeobox 2 (TGIF2) is a transcription regulator that is phosphorylated by EGFR/ ERK signaling. However, the functions of phosphorylated (p)-TGIF2 in cancer are largely unknown. Here, we investigated the roles of p-TGIF2 in promoting epithelial–mesenchymal transition (EMT) and metastasis in lung adenocarcinoma (LUAD).

15p vileonardodavinci 23-12-2023 4 2   Download

Novel strategies are needed to combat multidrug resistance in pancreatic ductal adenocarcinoma (PDAC). We applied genomic approaches to understand mechanisms of resistance in order to better inform treatment and precision medicine. Altered function of chromatin remodeling complexes contribute to chemoresistance.

14p vileonardodavinci 23-12-2023 6 2   Download

Increasing evidence suggests that cancer-derived extracellular vesicles (EVs) alter the phenotype and functions of fibroblasts and trigger the reprogramming of normal fibroblasts into cancer-associated fibroblasts (CAFs). Here, we for the first time studied the effects of urinary EVs from PC patients and healthy males on the transcriptional landscape of prostate CAFs and normal foreskin fibroblasts.

12p vialfrednobel 23-12-2023 6 3   Download