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Transcriptional regulatory programs
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The liver X receptors (LXRs, NR1H2 and NR1H3) and peroxisome proliferator-activated receptor gamma (PPARG, NR1C3) nuclear receptor transcription factors (TFs) are master regulators of energy homeostasis. Intriguingly, recent studies suggest that these metabolic regulators also impact tumor cell proliferation.
16p
vioraclene
31-03-2024
5
2
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Non-base-contacting residues enable kaleidoscopic evolution of metazoan C2H2 zinc finger DNA binding
The C2H2 zinc finger (C2H2-ZF) is the most numerous protein domain in many metazoans, but is not as frequent or diverse in other eukaryotes. The biochemical and evolutionary mechanisms that underlie the diversity of this DNA-binding domain exclusively in metazoans are, however, mostly unknown.
15p
vialfrednobel
29-01-2022
7
0
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Somatic cell reprogramming is the process that allows differentiated cells to revert to a pluripotent state. In contrast to the extensively studied rewiring of epigenetic and transcriptional programs required for reprogramming, the dynamics of post-transcriptional changes and their associated regulatory mechanisms remain poorly understood.
30p
viarchimedes
26-01-2022
6
0
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High-resolution transcription start site (TSS) mapping in D. melanogaster embryos and cell lines has revealed a rich and detailed landscape of both cis- and trans-regulatory elements and factors. However, TSS profiling has not been investigated in an orthogonal in vivo setting. Here, we present a comprehensive dataset that links TSS dynamics with nucleosome occupancy and gene expression in the wandering third instar larva, a developmental stage characterized by large-scale shifts in transcriptional programs in preparation for metamorphosis.
20p
vibeauty
23-10-2021
12
0
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Transcription factors are essential regulators of gene expression and play critical roles in development, differentiation, and in many cancers. To carry out their regulatory programs, they must cooperate in networks and bind simultaneously to sites in promoter or enhancer regions of genes. We hypothesize that the mRNA co-expression patterns of transcription factors can be used both to learn how they cooperate in networks and to distinguish between cancer types.
14p
vitzuyu2711
29-09-2021
11
1
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Coexpression network analysis is a powerful tool to reveal transcriptional regulatory mechanisms, identify transcription factors, and discover gene functions. It can also be used to investigate changes in coexpression patterns in response to environmental insults or changes in experimental conditions.
12p
vijeeni2711
30-06-2021
15
1
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Transcription factors (TFs) are important regulatory proteins that govern transcriptional regulation. Today, it is known that in higher organisms different TFs have to cooperate rather than acting individually in order to control complex genetic programs.
21p
vioklahoma2711
19-11-2020
11
3
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Under both physiological and pathological conditions gene expression programs are shaped through the interplay of regulatory proteins and their gene targets, interactions between which form intricate gene regulatory networks (GRN).
14p
vioklahoma2711
19-11-2020
6
1
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Next-generation sequencing (NGS) approaches are commonly used to identify key regulatory networks that drive transcriptional programs. Although these technologies are frequently used in biological studies, NGS data analysis remains a challenging, time-consuming, and often irreproducible process.
16p
viflorida2711
30-10-2020
7
1
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Reactivation of the telomerase reverse transcriptase gene TERT is a central feature for unlimited proliferation of the majority of cancers. However, the underlying regulatory processes are only partly understood.
12p
vicolorado2711
23-10-2020
26
0
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The transcription factor GATA3 is a favorable prognostic indicator in estrogen receptor-α (ERα)-positive breast tumors in which it participates with ERα and FOXA1 in a complex transcriptional regulatory program driving tumor growth. GATA3 mutations are frequent in breast cancer and have been classified as driver mutations.
14p
virose2711
24-09-2020
12
0
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Leaf senescence is an important developmental programmed degeneration process that dramatically affects crop quality and yield. The regulation of senescence is highly complex. Although senescence regulatory genes have been well characterized in model species such as Arabidopsis and rice, there is little information on the control of this process in cotton.
18p
viminato2711
22-05-2020
14
0
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Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs) that affect prime naive T cells and create proper immune responses. The uncontrolled growth of cancer cells often results from the cell’s successful inhibition of cytotoxic T lymphocytes. In addition to conventional cancer treatments, including surgery, chemotherapy, and radiation therapy, immunotherapies have been seen to offer promising and innovative cancer treatments. Currently, DC therapy is one of the most popular immunotherapies because it uses tumour antigen-pulsed DC vaccines to fight against cancers.
5p
caygaocaolon1
13-11-2019
10
0
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Transcriptional regulatory programs underlying barley germination and regulatory functions of Gibberellin and abscisic acid
24p
panasonic02
14-12-2011
52
3
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A recent, genome-wide study shows that the transcriptional program underlying leaf senescence is active and complex, reflecting the activation of more than 2,000 genes in Arabidopsis, with gene products involved in a broad spectrum of regulatory, biochemical and cellular events. reports deposited research Aging and senescence in plants Senescence, aging and death - conceived of in the past as inevitable, negative processes - are now considered an integral part of differentiation and development. Leaf senescence is one of the most conspicuous...
0p
thulanh21
15-11-2011
65
2
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Modulation of the transcription regulatory program in yeast cells committed to sporulation...
14p
thulanh20
10-11-2011
32
1
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