Transgenic model

Part 2 book "Pharmaceutical design and development" includes content: Rational design of drugs based on molecular structure, nucleic acid therapies, transgenic animal models, diagnostic applications of biotechnology, future prospects.

104p muasambanhan10 03-04-2024 3 2   Download

Alzheimer’s disease (AD) is characterized by the intra- and extracellular accumulation of amyloid-β (Aβ) peptides. How Aβ aggregates perturb the proteome in brains of patients and AD transgenic mouse models, remains largely unclear.

32p vicwell 29-02-2024 3 1   Download

In ebook "Prion proteins (Topics in current chemistry, Volume 305)" we have assembled a set of chapters highlighting various aspects of prion diseases in humans and animals which show the intriguing features of both physiological and pathogenic PrP conformers. In addition, a wide spectrum of methodological approaches are described, ranging from in silico, chemical, and in vitro approaches to animal models, to illustrate the elaborate and extensive technology established in the prion field, allowing the analysis of disease mechanisms and the development of diagnostic and therapeutic strategies.

308p manmanthanhla0201 26-02-2024 11 1   Download

Part 2 book "The genetics of the pig" includes content: Transgenics and modern reproductive technologies; developmental genetics; pig genetic resources; genetics of performance traits; genetics of meat quality and carcass traits; genetic improvement of the pig; pigs as a model for biomedical sciences; breeds of pigs; standard genetic nomenclature of the pig, with glossaries.

274p muasambanhan05 22-01-2024 5 2   Download

Part 1 book "Mouse as a model organism" includes content: Genomic insulators in transgenic animals, the german mouse clinic running an open access platform, nature and nurture - impacts on mouse phenotypes and translational research, the informatics of high throughput mouse phenotyping - Eumodic and beyond.

104p muasambanhan03 25-12-2023 2 1   Download

Part 1 book "The laboratory rabbit, guinea pig, hamster, and other rodents" includes content: Ethical considerations and regulatory issues; anesthesia and analgesia; clinical biochemistry and hematology; euthanasia and necropsy; zoonoses and occupational health; the domestic rabbit, oryctolagus cuniculus - origins and history; rabbit genetics and transgenic models; anatomy, physiology, and behavior; rabbit colony management and related health concerns; basic experimental methods in the rabbit.... and other contents.

442p muasambanhan02 25-12-2023 3 3   Download

Part 2 book "Animal models in cardiovascular research" includes content: Iatrogenic, transgenic, and naturally occurring models of cardiomyopathy and heart failure; naturally occurring, iatrogenic and transgenic models of atherosclerotic disease; animal models for the study of neurohumeral and central neural control of the cardiovascular system;....and other contents.

198p oursky10 07-12-2023 3 3   Download

Part 1 book "Transgenic mouse - Methods and protocols" includes content: Introduction - Strategies for developing genetically modified mice; genetic modification of the mouse - general technology – pronuclear and blastocyst injection; generation of chimeras by aggregation of embryonic stem cells with diploid or tetraploid mouse embryos; cryopreservation of mouse spermatozoa and in vitro fertilization; autopsy and histological analysis of the transgenic mouse; transgene design; inducible transgenic mouse models; lentiviral transgenesis; transgenesis in mouse embryonic stem cells.

175p oursky09 12-11-2023 4 3   Download

Part 2 book "Rabbit biotechnology - Rabbit genomics, transgenesis, cloning and models" includes content: Rabbit as a model for the study of human diseases, transgenic rabbits to prepare pharmaceutical proteins, derivation and characterization of rabbit embryonic stem cells - a review, rabbit cloning, the european rabbit genome.

68p oursky05 20-09-2023 2 1   Download

Cathelicidins, a family of host-defence peptides, are present in a diverse range of species, including fish, amphibians, birds, reptiles, and mammals. The evidence for the role of these cationic antimicrobial peptides in innate host defenses is convincing from the data of animal model and transgenic animal experiments as well as wildlife or domestic animals, indicating that the peptides protect against inflammatory and immune system after induction by bacterial infection.

8p vicaptainmarvel 21-04-2023 4 2   Download

Plant elicitor peptides (Peps) are endogenous molecules that induce and amplify the first line of inducible plant defense, known as pattern-triggered immunity, contributing to protect plants against attack by bacteria, fungi and herbivores. Pep topic application and transgenic expression have been found to enhance disease resistance in a small number of model plant-pathogen systems.

12p vinarcissa 21-03-2023 2 1   Download

BEX family genes are expressed in various tissues and play significant roles in neuronal development. A mouse model of Bex3 gene knock-out was generated in this study, using the CRISPR-Cas9 system. Transcriptomic analysis of the brain was performed to identify genes and pathways under Bex3 regulation. Essential biological functions under the control of Bex3 related to brain development were identified.

21p lyhuyenthu 31-01-2023 4 2   Download

Although uveal melanoma (UM) at the early stage is controllable to some extent, it inevitably ultimately leads to death due to its metastasis. At present, the difficulty is that there is no way to effectively tackle the metastasis.

13p vikolindagrabar 27-07-2022 3 1   Download

The CRISPR-Cas9 system is a widely utilized platform for transgenic animal production in various species, although its off-target effects should be addressed. Several applications of this tool have been proposed in model animals but remain insufficient for transgenic livestock production.

15p vialfrednobel 29-01-2022 5 1   Download

Conditional knockout mice and transgenic mice expressing recombinases, reporters, and inducible transcriptional activators are key for many genetic studies and comprise over 90% of mouse models created. Conditional knockout mice are generated using labor-intensive methods of homologous recombination in embryonic stem cells and are available for only ~25% of all mouse genes.

15p vialfrednobel 29-01-2022 14 0   Download

There is increasing interest in whether anesthetic agents affect the risk or progression of Alzheimer’s disease (AD). To mitigate many of the methodological issues encountered in human retrospective cohort studies we have used a transgenic model of AD to investigate the effect of propofol on AD pathology.

8p vampires36 30-12-2021 8 0   Download

In this study, we investigated whether osteoporosis-like phenotype could be induced in the transgenic larvae when heat-shock was applied at earlier time points, namely when larvae were at 1,2,3,4,5, or 6 dpf. The obtained results show that heat-shocks from the time point of 3 dpf onwards resulted in osteoporosis-like phenotype, while heat-shock at 1 or 2 dpf did not affect mineralized bone matrix in 11 dpf larvae.

7p guitaracoustic02 08-12-2021 7 1   Download

It is well known that development of prostate cancer (PC) can be attributed to somatic mutations of the genome, acquired within proto-oncogenes or tumor-suppressor genes. What is less well understood is how germline variation contributes to disease aggressiveness in PC patients. To map germline modifiers of aggressive neuroendocrine PC, we generated a genetically diverse F2 intercross population using the transgenic TRAMP mouse model and the wild-derived WSB/EiJ (WSB) strain.

16p vibeauty 23-10-2021 6 0   Download

Hydractinia symbiolongicarpus, a Hydractinia symbiolongicarpus, is a tractable model system for many cnidarianspecific and general biological questions. Until recently, tests of gene function in Hydractinia have relied on laborious forward genetic approaches, randomly integrated transgenes, or transient knockdown of mRNAs.

17p vitzuyu2711 29-09-2021 11 1   Download

Accumulation of protein aggregates are a major hallmark of progressive neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease. Transgenic Caenorhabditis elegans nematodes expressing the human synaptic protein α-synuclein in body wall muscle show inclusions of aggregated protein, which affects similar genetic pathways as in humans.

12p visilicon2711 20-08-2021 8 1   Download