Translational biomarkers
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Ebook "Bioinformatics for diagnosis, prognosis and treatment of complex diseases" introduces the bioinformatics tools, databases and strategies for the translational research, focuses on the biomarker discovery based on integrative data analysis and systems biological network reconstruction. With the coming of personal genomics era, the biomedical data will be accumulated fast and then it will become reality for the personalized and accurate diagnosis, prognosis and treatment of complex diseases.
219p lamquandat 28-12-2023 10 2 Download
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Ebook "Difference gel electrophoresis: Methods and protocols" provides a comprehensive update of this key method on gel-based proteomics. Chapters present an introduction into the development of methods on principles of differential protein labeling and two-dimensional gel electrophoresis, techniques on optimized proteomic workflows using advanced mass spectrometry for protein identification, and the application of those methods in basic biological research, pathobiology and applied biomarker discovery.
310p lucchinguyen 28-12-2023 5 2 Download
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The utilization of basket trials in oncology has gained popularity because of the drive for precision medicine and the increasing ease of genetically profiling tumors. However, it is unknown if this has translated into patient benefit, either through higher response rates because of precision treatment or because of increasing options for less-common tumor types that are less represented in oncology drug trials.
8p vileonardodavinci 23-12-2023 5 2 Download
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Part 1 book "Biomarkers in medicine, drug discovery, and environmental health" includes content: Biomarkers - An evolutionary perspective; genomics; proteomics for biomarker discovery; metabolic profiling for biomarker discovery; the bittersweet promise of glycobiology, biomarkers of alzheimer's and parkinson's disease; biomarkers of cardiac injury; lung injury biomarkers; translational biomarkers of acute drug induced liver injury - the current state, gaps, and future opportunities; biomarkers of acute kidney injury; in search of biomarkers for drug induced vascular injury.
336p oursky09 12-11-2023 5 3 Download
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Part 2 book "Biomarkers in medicine, drug discovery, and environmental health" includes content: Biomarkers of immunotoxicity; biomarkers in obstetric medicine; biomarkers in cancer, biomarkers of HIV, biomarkers of in vitro drug induced mitochondrial dysfunction, immunoassay based technologies for the measurement of biological materials used for biomarkers discovery and translational research, nanoscale techniques for biomarker quantification, immunodiagnostics with a focus on lateral flow point of care devices,.... and other contents.
312p oursky09 12-11-2023 3 2 Download
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Part 1 book "Biomarkers - In medicine, drug discovery, and environmental health" includes content: Biomarkers - An evolutionary perspective; genomics; proteomics for biomarker discovery; metabolic profiling for biomarker discovery, the bittersweet promise of glycobiology; biomarkers of Alzheimer's and Parkinson's disease; biomarkers of cardiac injury; lung injury biomarkers; translational biomarkers of acute drug induced liver injury - the current state, gaps, and future opportunities; biomarkers of acute kidney injury; in search of biomarkers for drug induced vascular injury.
336p oursky07 23-10-2023 3 1 Download
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Part 2 book "Biomarkers - In medicine, drug discovery, and environmental health" includes content: Biomarkers of immunotoxicity; biomarkers in obstetric medicine; biomarkers in cancer; biomarkers of HIV; biomarkers of in vitro drug induced mitochondrial dysfunction; immunoassay based technologies for the measurement of biological materials used for biomarkers discovery and translational research; nanoscale techniques for biomarker quantification; immunodiagnostics with a focus on lateral flow point of care devices,... and other contents.
312p oursky07 23-10-2023 7 1 Download
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Gliomas are the most common brain tumours with the high-grade glioblastoma representing the most aggressive and lethal form. Currently, there is a lack of specific glioma biomarkers that would aid tumour subtyping and minimally invasive early diagnosis. Aberrant glycosylation is an important post-translational modification in cancer and is implicated in glioma progression.
15p vischultz 20-10-2023 1 1 Download
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Bladder and urinary tract cancers account for approximately 21,000 new diagnoses and 5,000 deaths annually in the UK. Approximately 90% are transitional cell carcinomas where advanced disease is treated with platinum based chemotherapy and PD-1/PD-L1 directed immunotherapy.
11p vioracle 29-09-2023 2 2 Download
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Urothelial carcinoma (UC) is among the most prevalent malignancies. The muscle-invasive bladder cancer (MIBC) shows an invasive feature and has poor prognosis, while the non-muscle invasive bladder cancer (NMIBC) shows a better prognosis as compared with the MIBC.
16p vikolindagrabar 27-07-2022 3 1 Download
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The phase III clinical study of adjuvant liposomal muramyl tripeptide (MTP-PE) in resected high-grade osteosarcoma (OS) documented positive results that have been translated into regulatory approval, supporting initial promise for innate immune therapies in OS.
14p visusanwojcicki 28-06-2022 11 2 Download
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Post-translational modification plays an important role in the occurrence and development of various tumors. However, few researches were focusing on the SUMOylation regulatory genes as tumor biomarkers to predict the survival for specific patients. Here, we constructed and validated a two-gene signature to predict the overall survival (OS) of non-small cell lung cancer (NSCLC) patients.
12p visusanwojcicki 28-06-2022 9 3 Download
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Transcripts with alternative 5′-untranslated regions (UTRs) result from the activity of alternative promoters and they can determine gene expression by influencing its stability and translational efficiency, thus executing complex regulation of developmental, physiological and pathological processes.
9p vielonmusk 21-01-2022 10 0 Download
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Human cancer cell line profiling and drug sensitivity studies provide valuable information about the therapeutic potential of drugs and their possible mechanisms of action. The goal of those studies is to translate the findings from in vitro studies of cancer cell lines into in vivo therapeutic relevance and, eventually, patients’ care.
18p vilichoo2711 23-06-2021 22 1 Download
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Lung cancer is the leading cause of cancer-related death worldwide. Tremendous research efforts have been devoted to improving treatment procedures, but the average five-year overall survival rates are still less than 20%. Many biomarkers have been identified for predicting survival; challenges arise, however, in translating the findings into clinical practice due to their inconsistency and irreproducibility.
10p viwyoming2711 16-12-2020 9 1 Download
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Discovering robust markers for cancer prognosis based on gene expression data is an important yet challenging problem in translational bioinformatics. By integrating additional information in biological pathways or a protein-protein interaction (PPI) network, we can find better biomarkers that lead to more accurate and reproducible prognostic predictions.
10p vioklahoma2711 19-11-2020 11 0 Download
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Biomarker detection presents itself as a major means of translating biological data into clinical applications. Due to the recent advances in high throughput sequencing technologies, an increased number of metagenomics studies have suggested the dysbiosis in microbial communities as potential biomarker for certain diseases.
17p viflorida2711 30-10-2020 12 1 Download
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Analysis of high-throughput multi-’omics interactions across the hierarchy of expression has wide interest in making inferences with regard to biological function and biomarker discovery. Expression levels across different scales are determined by robust synthesis, regulation and degradation processes, and hence transcript (mRNA) measurements made by microarray/RNA-Seq only show modest correlation with corresponding protein levels.
13p vicolorado2711 23-10-2020 9 1 Download
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Bevacizumab, an antibody neutralizing Vascular Endothelial Growth Factor (VEGF), is licensed for the management of patients with advanced colon cancer. However, tumor biomarkers identifying the molecular tumor subsets most amenable to angiogenesis modulation are lacking.
10p virose2711 25-09-2020 15 1 Download
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The role of pERK, pAKT and p53 as biomarkers in patients with advanced pancreatic cancer has not yet been defined. Methods: Within the phase III study AIO-PK0104 281 patients with advanced pancreatic cancer received an erlotinib-based 1st-line regimen. Archival tissue from 153 patients was available for central immunohistochemistry staining for pERK, pAKT and p53.
10p vilisa271 22-09-2020 8 1 Download