Translational cancer research

Primary tumor removal by cytoreductive nephrectomy in synchronous metastatic renal cell carcinoma patients has been investigated in the context of various treatment regimens. Two randomized controlled trials investigated the role and timing of cytoreductive nephrectomy in the era of targeted therapy and demonstrated that upfront nephrectomy should no longer be performed when patients require systemic therapy.

8p vikoch 27-06-2024 1 1   Download

Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity.

774p vimeyers 29-05-2024 2 2   Download

The return of research results (RoR) remains a complex and well-debated issue. Despite the debate, actual data related to the experience of giving individual results back, and the impact these results may have on clinical care and health outcomes, is sorely lacking.

9p vioraclene 31-03-2024 5 2   Download

Hundreds of thousands of cancer patients have had targeted (panel) tumor sequencing to identify clinically meaningful mutations. In addition to improving patient outcomes, this activity has led to significant discoveries in basic and translational domains.

14p vibransone 28-03-2024 2 2   Download

Ebook "Nasopharyngeal carcinoma: Keys for translational medicine and biology" intends to contribute to “translational medicine and biology”. By this, we mean a bi-directional process whose aim is to develop knowledge from basic science towards diagnostic and therapeutic applications and reciprocally to raise new questions for basic scientists. One general requirement for translational research is to establish a multidisciplinary knowledge base shared by the actors of various specialties.

221p duongthandue0501 28-02-2024 4 1   Download

Ebook "Bioinformatics for diagnosis, prognosis and treatment of complex diseases" introduces the bioinformatics tools, databases and strategies for the translational research, focuses on the biomarker discovery based on integrative data analysis and systems biological network reconstruction. With the coming of personal genomics era, the biomedical data will be accumulated fast and then it will become reality for the personalized and accurate diagnosis, prognosis and treatment of complex diseases.

219p lamquandat 28-12-2023 10 2   Download

Research infrastructures such as biorepositories are essential to facilitate genomics and its growing applications in health research and translational medicine in Africa. Using a cervical cancer cohort, this study describes the establishment of a biorepository consisting of biospecimens and matched phenotype data for use in genomic association analysis and pharmacogenomics research.

12p vileonardodavinci 23-12-2023 3 2   Download

New concepts for a more efective anti-cancer therapy are urgently needed. Experimental faws rep‑ resent a major counter player of this development and lead to inaccurate and unreproducible data as well as unsuc‑ cessful translation of research approaches into clinics. In a previous study we have created epithelial cell cultures from head and neck squamous cell carcinoma (HNSCC) tissue.

13p vileonardodavinci 23-12-2023 2 2   Download

Part 2 book "Biomarkers in medicine, drug discovery, and environmental health" includes content: Biomarkers of immunotoxicity; biomarkers in obstetric medicine; biomarkers in cancer, biomarkers of HIV, biomarkers of in vitro drug induced mitochondrial dysfunction, immunoassay based technologies for the measurement of biological materials used for biomarkers discovery and translational research, nanoscale techniques for biomarker quantification, immunodiagnostics with a focus on lateral flow point of care devices,.... and other contents.

312p oursky09 12-11-2023 3 2   Download

Part 2 book "Biomarkers - In medicine, drug discovery, and environmental health" includes content: Biomarkers of immunotoxicity; biomarkers in obstetric medicine; biomarkers in cancer; biomarkers of HIV; biomarkers of in vitro drug induced mitochondrial dysfunction; immunoassay based technologies for the measurement of biological materials used for biomarkers discovery and translational research; nanoscale techniques for biomarker quantification; immunodiagnostics with a focus on lateral flow point of care devices,... and other contents.

312p oursky07 23-10-2023 8 1   Download

The prognosis of patients with advanced biliary tract cancer (BTC) who have progressed on gemcit‑abine plus cisplatin is dismal. Trifluridine/tipiracil (FTD/TPI) and irinotecan have proven efficacy in different gastroin‑ testinal malignancies. We therefore hypothesized that this combination might improve the therapeutic outcome in patients with BTC after failure of first-line treatment.

12p visharma 20-10-2023 3 2   Download

Heterogeneous tumor cells are thought to be a significant factor in the failure of endocrine therapy in estrogen receptor-positive (ER+) cancers. Culturing patient-derived breast cancer cells (PDBCCs) provides an invaluable tool in pre-clinical and translational research for the heterogeneity of cancer cells.

13p vioracle 29-09-2023 8 2   Download

Bladder and urinary tract cancers account for approximately 21,000 new diagnoses and 5,000 deaths annually in the UK. Approximately 90% are transitional cell carcinomas where advanced disease is treated with platinum based chemotherapy and PD-1/PD-L1 directed immunotherapy.

11p vioracle 29-09-2023 2 2   Download

Post-translational modification plays an important role in the occurrence and development of various tumors. However, few researches were focusing on the SUMOylation regulatory genes as tumor biomarkers to predict the survival for specific patients. Here, we constructed and validated a two-gene signature to predict the overall survival (OS) of non-small cell lung cancer (NSCLC) patients.

12p visusanwojcicki 28-06-2022 9 3   Download

Real-world data (RWD) is increasingly being embraced as an invaluable source of information to address clinical and policy-relevant questions that are unlikely to ever be answered by clinical trials. However, the largely unrealised potential of RWD is the value to be gained by supporting prospective studies and translational research.

9p visusanwojcicki 28-06-2022 10 2   Download

Cancer is a leading cause of mortality for both humans and dogs. As spontaneous canine cancers appear to be relevant models of human cancers, developing new therapeutic approaches could benefit both species. Oncolytic virotherapy is a promising therapeutic approach in cancer treatment.

13p vigandhi 23-02-2022 5 1   Download

Lung cancer is the leading cause of cancer-related death worldwide. Tremendous research efforts have been devoted to improving treatment procedures, but the average five-year overall survival rates are still less than 20%. Many biomarkers have been identified for predicting survival; challenges arise, however, in translating the findings into clinical practice due to their inconsistency and irreproducibility.

10p viwyoming2711 16-12-2020 9 1   Download

Bevacizumab, an antibody neutralizing Vascular Endothelial Growth Factor (VEGF), is licensed for the management of patients with advanced colon cancer. However, tumor biomarkers identifying the molecular tumor subsets most amenable to angiogenesis modulation are lacking.

10p virose2711 25-09-2020 15 1   Download

Translational biomedical research relies on the availability of human tissue to explore disease aetiology and prognostic factors, with the objective of developing better targeted treatments. The establishment of biobanks poses ongoing ethical considerations in relation to donors.

8p vialabama2711 21-09-2020 24 1   Download

Recently, the prognostic significance of circulating tumor cells (CTCs) in primary breast cancer as assessed using the Food-and-Drug-Administration-approved CellSearch® system has been demonstrated.

11p vinaypyidaw2711 26-08-2020 13 3   Download