Treatment settings
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Chemotherapeutic agents such as anthracyclines and taxanes are commonly used in the neoadjuvant setting. Bevacizumab is an antibody which binds to vascular endothelial growth factor A (VEGFA) and inhibits its receptor interaction, thus obstructing the formation of new blood vessels.
14p vibransone 28-03-2024 2 2 Download
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Small cell lung cancer (SCLC) is a more aggressive subtype of lung cancer that often results in rapid tumor growth, early metastasis, and acquired therapeutic resistance. Consequently, such phenotypical characteristics of SCLC set limitations on viable procedural options, making it difficult to develop both screenings and effective treatments.
20p vibransone 28-03-2024 2 2 Download
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Deep learning is a subdiscipline of artificial intelligence that uses a machine learning technique called artificial neural networks to extract patterns and make predictions from large data sets. The increasing adoption of deep learning across healthcare domains together with the availability of highly characterised cancer datasets has accelerated research into the utility of deep learning in the analysis of the complex biology of cancer.
17p vibransone 28-03-2024 2 2 Download
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Immune checkpoint inhibitor (ICI) therapy has revolutionized the treatment of many cancers. However, the limited population that benefits from ICI therapy makes it necessary to screen predictive biomarkers for stratifying patients. Currently, many biomarkers, such as tumor mutational burden (TMB), have been used in the clinic as indicative biomarkers.
21p viellison 28-03-2024 2 1 Download
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Resistance to third-generation cephalosporins, often mediated by extended-spectrum beta-lactamases (ESBLs), is a considerable issue in hospital-associated infections as few drugs remain for treatment. ESBL genes are often located on large plasmids that transfer horizontally between strains and species of Enterobacteriaceae and frequently confer resistance to additional drug classes.
13p viellison 28-03-2024 1 1 Download
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Part 1 book "Fast facts for the critical care nurse - Critical care nursing in a nutshell" includes content: Critical care nursing overview, the importance of documentation, advance directives and organ donation, withdrawal of treatment and palliative care, basic patient care in the critical care setting, patient nutrition, the sterile field, pre procedural patient preparation and consciouns sedation, isolation precautions and personal protective equipment, everything iv.
122p muasambanhan09 16-03-2024 1 1 Download
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Part 1 book "Varcarolis’ foundations of psychiatric-mental health nursing - A clinical approach" includes content: Mental health and mental illness, theories and therapies, theories and therapies, treatment settings, cultural implications, legal and ethical considerations, the nursing process and standards of care, therapeutic relationships, therapeutic communication, stress responses and stress management, childhood and neurodevelopmental disorders.
398p muasambanhan08 01-03-2024 0 0 Download
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Part 2 book "Practical physiotherapy for small animal practice" includes content: Therapeutic exercise; splints, supports and aids; pain; treatment protocols; setting up a physiotherapy clinic.
142p muasambanhan06 03-02-2024 4 1 Download
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Allergic rhinitis is the most common allergic disease encountered in a primary care setting. Diagnosis is often made clinically based on response to empiric therapy. However, with long-term treatment failure and/or atypical disease presentation, a differential diagnosis should be considered.
7p vilazada 31-01-2024 6 2 Download
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There is limited real-world evidence that describes patients with newly diagnosed multiple myeloma (NDMM) treated with the bortezomib, lenalidomide, and dexamethasone (VRd) triplet regimen. We evaluated patient characteristics and treatment outcomes among nontransplanted NDMM patients who received VRd as their first line of therapy (LOT) in US oncology practice settings.
9p vialfrednobel 23-12-2023 9 5 Download
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Although intrinsic immune-evasion is important in cancer proliferation, metastasis and response to treatment, it is unclear whether intrinsic immune-evasion patterns of gliomas can aid in predicting clinical prognosis and determining treatment.
17p vialfrednobel 23-12-2023 3 3 Download
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"Standard Specification for Quenched and Tempered Alloy Steel Bolts, Studs, and Other Externally Threaded Fasteners" covers the chemical and mechanical requirements of quenched and tempered alloy steel bolts, studs, and other externally threaded fasteners 4 in. and under in diameter for application at normal atmospheric temperatures, where high strength is required and for limited application at elevated temperature. Any alloy steel capable of meeting the minimum mechanical and chemical properties set forth in this specification may be used.
7p hth_hn_vn 10-12-2023 4 3 Download
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Part 2 book "Encyclopedia of aquarium and pond fish" includes content: What to consider, setting up the tank, lighting considerations, siting and substrate, heating and filtration, selecting the décor, preparing the tank, maintenance, food and feeding, monitoring and adjusting, illness and treatment; health concerns, breeding, reproduction and breeding,... and other contents.
200p oursky09 12-11-2023 8 4 Download
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The TROIKA trial established that HD201 and trastuzumab were equivalent in terms of primary end-points (total pathological complete response) following neoadjuvant treatment. The objective of the present analysis was to compare survival outcomes and final safety.
9p vischultz 20-10-2023 1 1 Download
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Optimal therapy for concomitant EGFR and TP53 mutated non-small cell lung cancer: A real-world study
Non-small cell cancer (NSCLC) patients with concomitant epidermal growth factor receptor (EGFR) and TP53 mutations have a poor prognosis with the treatment of tyrosine kinase inhibitors (TKIs), and may benefit from a combination regimen preferentially. The present study aims to compare the benefits of EGFR-TKIs and its combination with antiangiogenic drugs or chemotherapy in patients with NSCLC harboring EGFR and TP53 co-mutation in a reallife setting.
11p vischultz 20-10-2023 2 1 Download
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KRAS mutations occur frequently in advanced non-small cell lung cancer (aNSCLC); the G12C mutation is the most prevalent. Alterations in STK11 or KEAP1 commonly co-occur with KRAS mutations in aNSCLC.
11p vischultz 20-10-2023 4 1 Download
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Adjuvant postoperative treatment with aspirin and statins may improve survival in several solid tumors. This study aimed to assess whether these medications improve the survival after curatively intended treatment (including esophagectomy) for esophageal cancer in an unselected setting.
9p vischultz 20-10-2023 4 1 Download
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The long-term dynamic recurrence hazard of locally advanced gastric cancer (LAGC) in the clinical setting of adjuvant chemotherapy (ACT) remains unclear. Purpose This study aimed to investigate the dynamic recurrence risk of LAGC in patients who received ACT or not.
15p visharma 20-10-2023 4 2 Download
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To understand the proportion of uHCC (unresectable hepatocellular carcinoma) patients who achieve successful conversion resection in a high-volume setting with state of the art treatment options.
14p visharma 20-10-2023 4 2 Download
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Synovial sarcoma (SS) is one of the commonest non-rhabdomyosarcoma soft tissue sarcoma with limited treatment options in the relapsed and advanced settings. The combination of gemcitabine and docetaxel has demonstrated its role predominantly in leiomyosarcoma and pleomorphic sarcomas but has not been prospectively studied in SS.
10p vioracle 29-09-2023 3 2 Download