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Treatment targeting children
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Medulloblastoma (MB) is the most common malignant paediatric brain tumour and a leading cause of cancer-related mortality and morbidity. Existing treatment protocols are aggressive in nature resulting in significant neurological, intellectual and physical disabilities for the children undergoing treatment. Thus, there is an urgent need for improved, targeted therapies that minimize these harmful side effects.
15p
vibransone
28-03-2024
4
2
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Osteosarcoma (OS) mainly happens in children and youths. Surgery, radiotherapy and chemotherapy are the common therapies for osteosarcoma treatment but all their anti-tumor effects are limited.
12p
vileonardodavinci
23-12-2023
5
4
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Osteosarcoma is the most common primary bone cancer that affects mostly children and young adults. Despite the advances in osteosarcoma treatment, the long-term survival rate of metastatic patients has not significantly improved in the past few decades, thus demonstrating the need for novel therapeutic targets or methods to improve metastatic osteosarcoma treatment.
16p
vialfrednobel
23-12-2023
4
4
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Medulloblastoma is the most common malignant brain tumor of childhood. Although the clinical outcome for medulloblastoma patients has improved significantly, children afflicted with the disease frequently suffer from debilitating side effects related to the aggressive nature of currently available therapy.
11p
vijisoo2711
30-09-2020
12
0
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euroblastoma (NB) is an aggressive childhood malignancy in children up to 5 years of age. High-stage tumors frequently relapse even after aggressive multimodal treatment, and then show therapy resistance, typically resulting in patient death. New molecular-targeted compounds that effectively suppress tumor growth and prevent relapse with more efficacy are urgently needed.
11p
viamsterdam
18-09-2020
17
1
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Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in children. NAFLD has emerged to be extremely prevalent, and predicted by obesity and male gender. It is defined by hepatic fat infiltration >5% hepatocytes, in the absence of other causes of liver pathology.
10p
vivalanbo2711
19-03-2020
15
1
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This paper describes a detailed protocol for manual intramuscular needle placement checked by passive stretching and relaxing of the target muscle for each individual muscle injection location in the lower extremity during botulinum toxin type-A treatment under general anaesthesia in children with spastic cerebral palsy.
8p
vivalanbo2711
19-03-2020
13
2
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Pseudo-ascites is a very rare condition in children and remains a challenging diagnosis. Targeted imaging may be helpful, but a high index of clinical suspicion is often necessary to guide the investigations, as pseudo-ascites may efficiently mimic true ascites.
4p
vivalletta2711
11-01-2020
10
1
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Autism spectrum disorder (ASD) is a heterogeneous group of neurodevelopmental disorders. Genetically based subtype identification may prove more beneficial not only in illuminating the course and prognosis, but also for individualized treatment targets of an ASD sub-group.
7p
vidublin2711
13-01-2020
11
0
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Upper limb (UL) deficits in children with unilateral cerebral palsy (uCP) have traditionally been targeted with motor execution treatment models, such as modified Constraint-Induced Movement Therapy (mCIMT). However, new approaches based on a neurophysiological model such as Action-Observation Training (AOT) may provide new opportunities for enhanced motor learning.
13p
vidublin2711
13-01-2020
17
1
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For the first time to our knowledge, short- and long-term effects of a multi-site randomizedcontrolled trial (RCT) of video feedback of infant–parent interaction (VIPI) intervention in naturalistic settings are published. The intervention targets families with children younger than 2 years old and parent–child interactions problems.
20p
vilisbon2711
07-01-2020
13
3
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Several databases were comprehensively searched for studies published from January 1980 through February 2018 that reviewed effects of parental opioid addiction on parent–child relationships and outcomes of children (age, 0–16 years).
11p
vigustavia2711
19-12-2019
5
0
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The ADB estimates that additional government investment of only around $3 per person per year, spent carefully to target specific healthcare gaps, could bring the MDGs within reach. Private sector contribution to health coverage is a vital component of strategies for meeting MDGs Four and Five. However, this should not detract from or replace government responsibility for public health care.
51p
nhamnhiqa
01-03-2013
39
2
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WHO’s advocacy will emphasize the additional health sector investments required to achieve the Millennium Development Goals and targets and the goal of universal access. Although the current global economic climate is threatening both domestic and overseas development assistance, new directions and opportunities for attaining universal access are emerging: combination prevention; the Treatment 2.0 platform; eliminating new HIV infections among children; and the emerging scientific and programmatic evidence guiding the development of new, more effective approaches to HIV.
531p
nhamnhiqa
01-03-2013
38
2
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In sub-Saharan Africa, 10 to 20 percent of children die before turning five, and maternal deaths from pregnancy-related events, rare in most industrialized countries, occur far too frequently. As of 2010, only 19 of the 68 Countdown to 2015 priority countries—which account for more than 90% of maternal and child deaths worldwide— were on track to meet the target on child survival. Maternal mortality continues to remain high with little evidence of progress.
72p
nhamnhiqa
01-03-2013
69
2
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Research conducted for Missing the Target 7 by civil society activists on-the- ground in six countries (Argentina, Cambodia, Moldova, Morocco, Uganda, and Zimbabwe) shows that efforts to prevent vertical transmission are failing to reach the very group it was designed for—HIV-positive pregnant women.
33p
le_minh_nha
18-12-2012
57
4
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Cushing’s disease is rare in children and adolescents. We report the clinical presenta- tions of three children with Cushing’s disease. All three exhibited the typical symptoms and signs of weight gain and growth retardation. Two also demonstrated personality changes, hypertension and hypokalemia, the last of these being rarely reported in patients with Cushing’s disease. Lack of diurnal changes in serum cortisol levels was the most common biochemical finding.
10p
connicquy
14-12-2012
73
2
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PSI began working in Cambodia in 1993 and has successfully social marketed a number of health products over the past 14 years. PSI/Cambodia and the MOH jointly decided to address the gaps in appropriate diarrhea treatment by launching a diarrhea treatment kit (DTK), a prepackaged product consisting of two sachets of low-osmolarity ORS and 10 tablets of zinc sulfate.
16p
connicquy
14-12-2012
32
3
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In recent years, in other disciplines as well, countries worldwide have been conducting large national studies targeting people. It is thought that each country intends to collect information about the people in these studies as part of its national strategy and accumulate it as intellectual property for the health and medical care of future generations. The United Kingdom, for example, is conducting research to determine the effects of lifestyle, the environment, and genetics, targeting 500,000 adults.
7p
connhobinh
10-12-2012
38
0
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Strategic Approach: 1) Utilize high throughput genomic/genetic platforms to characterize genetic susceptibility biomarkers of childhood cancer/cancer stem cells and to identify targets for novel tumour stem cell-directed molecular therapeutics, 2) develop advanced mechanisms and ethical/regulatory guidelines to conduct population-based genetic/genomic studies in children, 3) link biobanks to high-throughput functional analysis of individual tumours to assess responses to drugs and growth factors, adverse reactions to treatment, long-term side effects of treatment, and genome-wide ex...
0p
connhobinh
10-12-2012
58
2
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