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Trophoblastic neoplasia
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Single-agent chemotherapy using methotrexate or actinomycin D is the first-line treatment for patients with low-risk gestational trophoblastic neoplasia. Various methotrexate-based and actinomycin D-based single-agent regimens can be used.
7p
vioracle
29-09-2023
3
2
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To investigate the clinicopathological characteristics, diagnoses, treatments, and outcomes of a special type of gestational trophoblastic neoplasia (GTN) which only has extrauterine metastases without uterine primary lesions.
11p
viangelamerkel
27-07-2022
5
2
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Actinomycin-D (Act-D) and Methotrexate (MTX) are both effective first-line agents for low-risk gestational trophoblastic neoplasia (LRGTN) with no consensus regarding which is more effective or less toxic. The primary objective of this meta-analysis is to compare Act-D with MTX in the treatment of LRGTN.
14p
vimahuateng
26-11-2021
6
2
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To evaluate characteristics of hydatidiform mole, especially ultrasound imaging and serum β-hCG level. Moreover, β-hCG monitoring strategy posthydatidiform mole gestational neoplasia was analysed.
8p
viminnesota2711
22-03-2021
11
2
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The optimal treatment for patients with brain metastasis from gestational trophoblastic neoplasia (GTN) has not been established. This study aims to investigate the clinical characteristics and the management of brain metastasis from GTN in relation to patients’ outcomes.
9p
vialabama2711
21-09-2020
12
2
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Describe characteristics of uterine artery doppler ultrasound and prognostic factors in GTN patient treated by Methotrexat. Evaluate the effectiveness of uterine artery doppler ultrasound combined with related factor to predict MTX resistance in low-risk GTN patients.
24p
gaocaolon7
18-09-2020
21
2
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The objective of our study was to investigate the clinical characteristics and prognosis of postterm choriocarcinoma patients at Peking Union Medical College Hospital within the past 30 years. Methods: The clinical characteristics and pertinent follow-up data of 272 patients with postterm choriocarcinoma diagnosed from December 1985 through December 2014 in our hospital were reviewed.
8p
vinaypyidaw2711
26-08-2020
11
2
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HELLP syndrome is a combination of symptoms described as hemolysis, elevated liver enzymes and low platelets, that complicates 0.01–0.6 % of pregnancies. HELLP syndrome has been scarcely reported associated with partial moles, another rare complication of pregnancy.
5p
vimale2711
25-08-2020
11
1
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There are three main therapeutic strategies, namely expectant management (dilation and curettage only), prophylactic chemotherapy and prophylactic total hysterectomy for treating older women with complete hydatidiform mole (CHM).
7p
vimanama2711
30-07-2020
9
2
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Little data exists predicting the resistance to actinomycin D (Act-D) single-agent for gestational trophoblastic neoplasia (GTN). The objective was to determine the overall success of pulse Act-D and the factors predictive of resistance to pulse Act-D in the treatment of low-risk, non-choriocarcinoma post-molar GTN.
6p
vibaku2711
22-07-2020
14
2
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The clinical value of total hysterectomy for patients with hydatidiform mole (HM) being at least 40 years old remains highly controversial. Since the practice of hysterectomy has been applied globally for decades, there is an urgent need to perform a systematic review to assess its risks and benefits.
9p
viputrajaya2711
22-06-2020
9
0
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Gestational choriocarcinoma is a rare malignancy believed to arise from the trophoblast cells of the placenta. Despite the frequently aggressive clinical nature, choriocarcinoma has been routinely curable with cytotoxic chemotherapy for over 50 years.
10p
vikuala271
13-06-2020
10
0
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Etoposide (E) at 100 mg/m2 combined with Cisplatin (P) at 20 mg/m2 represents an induction 2-day regimen embedded in our clinical practice for patients with advanced GCT or TN at high risk of early death.
9p
vikuala271
13-06-2020
9
0
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Neo-angiogenesis is an early sign of cancers. This study assessed if among low-risk gestational trophoblastic neoplasia (LR-GTN) patients, the uterine artery pulsatility index (UAPI), which is a measure of tumor vascularity, can be an independent predictor to resistance to methotrexate chemotherapy (MTX-R).
9p
viartemis2711
22-10-2019
12
1
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Objectives: To describe the characteristics of gestational trophoblastic neoplasm (GTN) patients in period of July 2015 to August 2016 at the National Hospital of Obstetrics and Gynecology and to indicate the causes of late diagnostic of the GTN patients.
8p
jangni2
20-04-2018
25
0
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Gestational trophoblastic neoplasia with retroperitoneal metastases: A fatal complication
6p
matuot_238
12-10-2011
42
2
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Gestational trophoblastic neoplasias are neoplasms arising from placental syncytiotrophoblasts and cytotrophoblasts. The four tumors are: Hydatidiform mole (complete or partial) Invasive mole Choriocarcinoma Placental site trophoblastic tumor
41p
lananhanh123
27-08-2011
51
2
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Clinical Presentation Molar pregnancies are generally associated with first-trimester bleeding and excessive uterine size. About 45% of patients have ovarian theca-lutein cysts present on ultrasound. The β-hCG levels are generally markedly elevated. Fetal parts and heart sounds are not present. The diagnosis is generally made by the passage of grapelike clusters from the uterus, but ultrasound demonstration of the hydropic mole can be diagnostic. Patients suspected of a molar pregnancy require a chest film, careful pelvic examinations, and weekly serial monitoring of β-hCG levels.
7p
konheokonmummim
03-12-2010
86
5
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