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Tumor differentiations
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Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, and its molecular mechanisms are unclear. Nucleolar and spindle-associated protein 1 (NUSAP1), an indispensable mitotic regulator, has been reported to be involved in the development of several types of tumors.
16p
vikoch
27-06-2024
1
1
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Accurate lung cancer classification is crucial to guide therapeutic decisions. However, histological subtyping by pathologists requires tumor tissue—a necessity that is often intrinsically associated with procedural difficulties. The analysis of circulating tumor DNA present in minimal-invasive blood samples, referred to as liquid biopsies, could therefore emerge as an attractive alternative.
12p
vibransone
28-03-2024
6
2
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Large numbers of autosomal sites are found differentially methylated in the aging genome. Due to analytical difficulties in dealing with sex differences in X-chromosome content and X-inactivation (XCI) in females, this has not been explored for the X chromosome.
13p
vibransone
28-03-2024
1
1
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Endogenous retroelements (EREs) constitute about 42% of the human genome and have been implicated in common human diseases such as autoimmunity and cancer. The dominant paradigm holds that EREs are expressed in embryonic stem cells (ESCs) and germline cells but are repressed in differentiated somatic cells.
16p
vibransone
28-03-2024
7
2
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Populations of closely related microbial strains can be simultaneously present in bacterial communities such as the human gut microbiome. We recently developed a de novo genome assembly approach that uses read cloud sequencing to provide more complete microbial genome drafts, enabling precise differentiation and tracking of strain-level dynamics across metagenomic samples.
17p
vibransone
28-03-2024
9
1
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Precision medicine approaches are ideally suited for rare tumors where comprehensive characterization may have diagnostic, prognostic, and therapeutic value. We describe the clinical case and molecular characterization of an adolescent with metastatic poorly differentiated carcinoma (PDC).
17p
vioraclene
31-03-2024
8
1
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Epigenetic alterations are associated with normal biological processes such as aging or differentiation. Changes in global epigenetic signatures, together with genetic alterations, are driving events in several diseases including cancer. Comparative studies of cancer and healthy tissues found alterations in patterns of DNA methylation, histone posttranslational modifications, and changes in chromatin accessibility.
12p
vibransone
28-03-2024
7
2
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The human leukocyte antigen class I (HLA-I) genotype has been linked with differential immune responses to infectious disease and cancer. However, the clinical relevance of germline HLA-mediated immunity in gastrointestinal (GI) cancer remains elusive.
15p
vibransone
28-03-2024
5
2
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Pancreatic neuroendocrine neoplasms (PanNENs) fall into two subclasses: the well-differentiated, lowto high-grade pancreatic neuroendocrine tumors (PanNETs), and the poorly-differentiated, high-grade pancreatic neuroendocrine carcinomas (PanNECs). While recent studies suggest an endocrine descent of PanNETs, the origin of PanNECs remains unknown.
14p
viellison
28-03-2024
3
2
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Steatohepatitic hepatocellular carcinoma (SH-HCC) is one of the most common hepatocellular carcinoma (HCC) subtypes, with a frequency of 5-20%. These tumor are well-differentiated and show distinct histologic features resembling steatohepatitis: Macrovesicular steatosis, inflammation, balloon cells, Mallory-Denk bodies and pericellular fibrosis.
6p
vilarry
12-03-2024
3
2
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Ebook "Endocrine pathology: Differential diagnosis and molecular advances (Second edition)" provides detailed coverage of endocrine pathology with extensive discussion of the differential diagnosis as well as presentation of molecular pathobiology of the major endocrine organs. Revised and expanded from the first edition, each chapter, written by leaders in their respective field, has been updated with the latest advances that are transforming the field of endocrine pathology.
602p
duongthandue0501
28-02-2024
5
1
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In ebook "Advances in cancer stem cell biology" tumor-maintaining cells or cancer stem-like cells are a subpopulation of cancer cells that acquired some of the characteristics of stem cells to survive and adapt to ever-changing environments. These include the ability to self-renew and the capacity to produce progenitors that differentiate into other cell types.
349p
duongthandue0501
28-02-2024
3
1
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Allergic rhinitis is the most common allergic disease encountered in a primary care setting. Diagnosis is often made clinically based on response to empiric therapy. However, with long-term treatment failure and/or atypical disease presentation, a differential diagnosis should be considered.
7p
vilazada
31-01-2024
6
2
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Schwannomas are solitary well-circumscribed encapsulated benign tumors that exhibit Schwann cell differentiation, and arise directly from myelinated peripheral or central nerves. Although they are usually asymptomatic and found incidentally, schwannomas can cause symptoms due to compression of nearby structures which, depending on the location, can make clinical presentations widely variable.
4p
vitiki
30-01-2024
8
2
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Gastrointestinal stromal tumor is considered the most common mesenchymal neoplasm of the gastrointestinal tract. The majority of gastrointestinal stromal tumor cases are located in the stomach and usually affect older adults.
5p
vitiki
30-01-2024
3
2
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Papillary thyroid carcinoma accounts for the most common type of thyroid cancer of well-differentiated type. Papillary thyroid carcinoma is featured by biologically low-grade and less aggressive tumors with a survival rate of 10 years in most of the diagnosed cases.
8p
vitiki
30-01-2024
6
2
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The abscopal effect is a phenomenon in which a tumor located far from irradiated lesions regresses. We have experienced a case in which both intracranial and extracranial lesions showed an abscopal effect after radiotherapy for spinal metastases of unknown primary. We report the diferential abscopal effect in extracranial and intracranial lesions.
12p
vitiki
30-01-2024
6
2
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Pure tubular breast carcinoma is a rare and well-differentiated tumor with high survival and low local recurrence rate. Our study aims to determine the clinical, radiological, appropriate management, and prognosis of this carcinoma.
5p
vitiki
30-01-2024
6
2
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Plasmacytoma, a localized tumor of monoclonal plasma cells without any clinical, radiological or physical evidence of plasma cell neoplasm (PCN), is a rare entity that accounts for 1% of PCN. Immunoglobulin M (IgM) extramedullary plasmacytoma of mediastinal region has never been reported and is a diagnostic challenge considering other differential diagnoses.
8p
vitiki
30-01-2024
6
2
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Neuroendocrine differentiation (NED) in colorectal cancer (CRC) cells has been known for decades, and our previous meta-analysis indicated that CRC patients with neuroendocrine differentiation have a lower 5-year survival rate. In recent years, an increasing number of studies have found that exosome-derived long non-coding RNAs (lncRNAs) play important roles in cancer progression and metastasis.
17p
vimichaelfaraday
28-12-2023
11
3
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