Tumor tissues

Soft tissue sarcomas (STS), have significant inter- and intra-tumoral heterogeneity, with poor response to standard neoadjuvant radiotherapy (RT). Achieving a favorable pathologic response (FPR≥95%) from RT is associated with improved patient outcome.

16p vishanshan 27-06-2024 1 1   Download

Accurate evaluation of axillary lymph node metastasis (LNM) in breast cancer is very important. A large number of hyperplastic and dilated lymphangiogenesis cases can usually be found in the pericancerous tissue of breast cancer to promote the occurrence of tumor metastasis.

9p vishanshan 27-06-2024 1 1   Download

Biliary tract cancer (BTC) is a relatively rare but aggressive gastrointestinal cancer with a high mortality rate. Cancer stem cell (CSC) populations play crucial roles in tumor biology and are responsible for the low response to anti-cancer treatment and the high recurrence rate. This study investigated the role of Transgelin-2 (TAGLN2), overexpressed in CSC in BTC cells, and analyzed its expression in patient tissues and serum to identify potential new targets for BTC.

15p vishanshan 27-06-2024 1 1   Download

GBM is the most frequent malignant primary brain tumor in humans. The CLEC19A is a member of the C-type lectin family, which has a high expression in brain tissue. Herein, we sought to carry out an in-depth analysis to pinpoint the role of CLEC19A expression in GBM.

20p vishanshan 27-06-2024 2 1   Download

Emerging evidence suggests the dysregulation of long non-coding RNAs (lncRNAs) involved in pancreatic cancer (PC). However, the function of LINC00930 in PC has not been elaborated. In this study, we found that LINC00930 was significantly down-regulated in PC cell lines and tissues, and associated with tumor size, lymphatic metastasis, TNM stage and poor prognosis.

14p vishanshan 27-06-2024 2 1   Download

Gliomas are the deadliest malignant tumors of the adult central nervous system. We previously discovered that beta2-microglobulin (B2M) is abnormally upregulated in glioma tissues and that it exerts a range of oncogenic effects. Besides its tissue presence, serum B2M levels serve as biomarkers for various diseases. This study aimed to explore whether serum B2M levels can be used in the diagnosis and prognosis of gliomas.

10p vikoch 27-06-2024 1 1   Download

Almost one third of cancer patients in the United States will develop brain metastases on an annual basis. Surgical resection is indicated in the setting of brain metastases for reasons, such as maximizing local control in select patients, decompression of mass effect, and/or tissue diagnosis.

8p vikoch 27-06-2024 2 1   Download

This study aims to investigate the expression of UBQLN1 in lung cancer (LC) tissue and the diagnostic capability of autoantibody to UBQLN1 (anti-UBQLN1) in the detection of LC and the discrimination of pulmonary nodules (PNs).

17p vikoch 27-06-2024 1 1   Download

This study aimed to investigate the role of chemo- and radiotherapy in the formation of tumor necrosis and to evaluate the influence of tumor necrosis on overall survival and local recurrence-free survival. Data from BS patients and patients who did not receive neoadjuvant therapy were compared.

9p vikoch 27-06-2024 3 1   Download

Cancer-associated fibroblasts (CAFs) play an important role in the tumor microenvironment. Despite the well-known in vitro antitumoral efect of vitamin D3 (VD3), its impact on breast CAFs is almost unknown. In this study, we analyzed the ex vivo effects of calcitriol on CAFs isolated from breast cancer tissues.

25p vikoch 27-06-2024 2 1   Download

The prognostic significance of mast cells and different phenotypes of macrophages in the microenvironment of hepatocellular carcinoma (HCC) following resection is unclear. We aimed in this study to assess the local distribution of infiltrating macrophages and mast cells of specific phenotypes in tissues of HCC and to evaluate their prognostic values for survival of post-surgical patients.

13p vikoch 27-06-2024 2 1   Download

To evaluate the results of soft tissue defect treatment with ALT composite flaps in covering secondary soft tissue defects after radical tumors resection. Method: From October 2017 to April 2023, we performed a series of 10 single-stage surgeries using composite anterior lateral thigh flap to cover secondary tissue defects in 2 cases covered Achilles tendon defects and 8 cases covered secondary defects after resection of tumors.

6p viambani 21-05-2024 2 1   Download

Part 2 book "Robbins basic pathology" includes content: Heart, hematopoietic and lymphoid systems, lung, kidney and its collecting system, oral cavities and gastrointestinal tract, liver and gallbladder; male genital system and lower urinary tract; female genital system and breast; bones, joints, and soft tissue tumors, peripheral nerves and muscles; central nervous system; skin.

505p zizaybay1101 30-04-2024 2 2   Download

Part 1 book "Oral medicine and pathology - A guide to diagnosis and management" includes content: Anomalies of teeth, pathology of dental caries, periodontal diseases, inflammatory disorders of jaws including necrosis, cysts of the oral and maxillofacial region, odontogenic tumors, fibrocemento osseous lesions and related conditions, soft tissue and bone tumors, diseases of the maxillary antrum, salivary gland disorders, xerostomia.

286p muasambanhan10 06-04-2024 0 0   Download

Part 2 book "Pocket companion to Robbins cotran pathologic basis of disease" includes content: Red blood cells andbleeding disorders; the lung; head and neck; the gastrointestinal tract; liver and biliary tract; the pancreas; the kidney; the lower urinary tract and male genital system; the female genital tract; the breast; the endocrine system; the skin; bones, joints, and soft tissue tumors; peripheral nerve and skeletal muscle; the central nervous system; the eye.

432p muasambanhan10 06-04-2024 4 0   Download

In particular, immuno-histopathological analysis of biopsies sample from breast tumor showed an overexpressing of vimentin marker (68.1%) in cells which indicated status of malignant metastasis. The metastatic tumor cells in breast tumor might cause the change in blood biochemical parameters together with sepsis, thus the dog was not eligible for surgery.

4p visergey 02-04-2024 5 0   Download

Comprehensive mutational profiling data now available on all major cancers have led to proposals of novel molecular tumor classifications that modify or replace the established organ- and tissue-based tumor typing. The rationale behind such molecular reclassifications is that genetic alterations underlying cancer pathology predict response to therapy and may therefore offer a more precise view on cancer than histology.

17p vibransone 28-03-2024 4 2   Download

Transcriptome analysis of breast cancer discovered distinct disease subtypes of clinical significance. However, it remains a challenge to define disease biology solely based on gene expression because tumor biology is often the result of protein function. Here, we measured global proteome and transcriptome expression in human breast tumors and adjacent non-cancerous tissue and performed an integrated proteotranscriptomic analysis.

14p vibransone 28-03-2024 2 2   Download

Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic phenotypes of this disease based on 873 biopsy specimens collected in the German Cancer Aid MMML (Molecular Mechanisms in Malignant Lymphoma) consortium.

20p vibransone 28-03-2024 2 1   Download

Patient stratification based on molecular subtypes is an important strategy for cancer precision medicine. Deriving clinically informative cancer molecular subtypes from transcriptomic data generated on whole tumor tissue samples is a non-trivial task, especially given the various non-cancer cellular elements intertwined with cancer cells in the tumor microenvironment.

22p vibransone 28-03-2024 3 2   Download