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Tumour associated antigen
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Cerebellar degeneration-related (CDR) proteins are associated with paraneoplastic cerebellar degeneration (PCD) – a rare, neurodegenerative disease caused by tumour-induced autoimmunity against neural antigens resulting in degeneration of Purkinje neurons in the cerebellum.
16p
vikoch
27-06-2024
1
1
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The aim of this research was to design an electrochemical immunosensor for determination of tumour necrosis factor receptor-associated protein-1(TRAP1) antigen, a heat shock protein linked to tumour necrosis factor. The indium-tin oxide covered polyethylene terephthalate (ITO-PET) electrode surface was cleaned and was prepared for the introduction of hydroxyl groups on its surface by using NH4 OH/H2 O2 /H2 O. As a silanization agent for covalent attachment of anti-TRAP1 on the surface of the ITO working electrode, 3-glycidoxypropyltrimethoxysilane (3-GOPS) was used.
11p
tudichquannguyet
29-11-2021
9
1
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Cancer-testis antigens (CTAs) and tumour-associated antigens (TAAs) are frequently expressed in hepatocellular carcinoma (HCC); however, the role of tumour-antigen-specific T cell immunity in HCC progression is poorly defined. We characterized CTA- and TAA-specific T cell responses in different HCC stages and investigated their alterations during HCC progression.
11p
vimahuateng
26-11-2021
8
1
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Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a multifunctional Ig-like cell adhesion molecule that has a wide range of biological functions. According to previous reports, serum CEACAM1 is dysregulated in different malignant tumours and associated with tumour progression.
10p
vijennie2711
29-09-2020
17
0
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Therefore in this study immunodominant region in TP53 gene was amplified and cloned in prokaryotic expression vector. Further the conditions were optimized for the expression of the recombinant protein. The recombinant protein was purified using Ni-NTA affinity chromatography. The hyperimmune sera were raised in rabbits against the recombinant protein. In the hyperimmune sera, antibodies specific to TP53 were detected by Indirect ELISA, confirming the serological reactivity of the immunodominant region.
8p
nguaconbaynhay7
15-08-2020
12
2
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Solitary pulmonary nodules (SPNs) is a common radiographic finding and require further evaluation because of the possibility of lung cancer.
8p
vikuala271
13-06-2020
12
1
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Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs) that affect prime naive T cells and create proper immune responses. The uncontrolled growth of cancer cells often results from the cell’s successful inhibition of cytotoxic T lymphocytes. In addition to conventional cancer treatments, including surgery, chemotherapy, and radiation therapy, immunotherapies have been seen to offer promising and innovative cancer treatments. Currently, DC therapy is one of the most popular immunotherapies because it uses tumour antigen-pulsed DC vaccines to fight against cancers.
5p
caygaocaolon1
13-11-2019
10
0
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