Type III secretion system

Diarrhea is the leading cause of infant mortality worldwide, especially in the developing world. Among various etiologic agents within the Escherichia genus, Escherichia albertii is becoming recognized as a significant human enteropathogen. There has been little knowledge about the colonization and infection of E. albertii in comparison to its close relatives, E. coli.

11p viinuzuka 28-02-2025 1 1   Download

pH-Dependent structural changes forEscherichia coliO157:H7 EspA were characterized by CD, 8-anilino-2-naphthyl sulfonic acid (ANS) fluores-cence, and sedimentation equilibrium ultracentrifugation. Far- and near-UV CD spectra, recorded between pH 2.0 and 7.0, indicate that the protein has significant amounts of secondary and tertiary structures. An increase in ANS fluorescence intensity (in the presence of EspA) was observed at aci-dic pH;

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The structural properties of EspB, a virulence factor of theEscherichia coli O157 type III secretion system, were characterized. Far-UV and near-UV CD spectra, recorded between pH 1.0 and pH 7.0, show that the protein assumesa-helical structures and that some tyrosine tertiary contacts may exist. All tyrosine side-chains are exposed to water, as determined by acryl-amide fluorescence quenching spectroscopy.

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Type III secretion systems of Gram-negative pathogenic bacteria allow the injection of effector proteins into the cytosol of host eukaryotic cells. Cros-sing of the eukaryotic plasma membrane is facilitated by a translocon, an oligomeric structure made up of two bacterial proteins inserted into the host membrane during infection.

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EspB is a multifunctional protein associated with the type III secretion system of enterohaemorrhagic Escherichia coli, and interacts with various biomolecules includinga-catenin in the host cell. The binding of EspB to a-catenin is thought be involved in actin reorganization during bacterial infection, although the precise mechanism of this phenomenon is still unclear.

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Enterohemorrhagic and enteropathogenicEscherichia coliproduce various effector proteins that are directly injected into the host-cell cytosol through the type III secretion system. E. colisecreted protein (Esp)B is one such effector protein, and affects host-cell morphology by reorganizing actin net-works.

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EnterohemorrhagicEscherichia coli(EHEC) and enteropathogenic Escheri-chia coli (EPEC) are attaching⁄effacing pathogens that possess a type III secretion system and deliver a variety of effectors into host cells for suc-cessful infection. EHEC produces at least 20 effector families with various functions.

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Tham khảo luận văn - đề án 'báo cáo y học: " always one step ahead: how pathogenic bacteria use the type iii secretion system to manipulate the intestinal mucosal immune system"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system...

10p thulanh26 09-12-2011 57 5   Download