![](images/graphics/blank.gif)
Tyrosine phosphatase 1
-
Euonymus laxiflorus bioactive compounds 1-β-D-glucopyranosyloxy-3,5-dimethoxy-4- hydroxybenzene (1), Walterolactone A/B β-D-pyranoglucoside (2), Gallocatechin (3), Leonuriside A (4), Methyl galloate (5), and Catechin (6) were experimentally evidenced for their multi-inhibition against αglucosidase and α-amylase.
16p
viritesh
02-04-2024
2
1
Download
-
Lymphoma represents a heterogeneous group of cancers affecting the lymphatic system, encompassing nonHodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). The majority of NHL cases originate from B cells. HL is characterized by the presence of rare Hodgkin and Reed-Sternberg cells. Within the context of the inflammatory response, two SH2 domain-containing protein tyrosine phosphatases (SHPs), namely SHP-1 and SHP-2, serve as negative regulators.
6p
viellison
28-03-2024
2
2
Download
-
Tumor-suppressor genes are inactivated by methylation in several cancers including acute myeloid leukemia (AML). Src homology-2 (SH2)-containing protein-tyrosine phosphatase 1 (SHP-1) is a negative regulator of the JAK/STAT pathway.
11p
vimoscow2711
29-08-2020
5
0
Download
-
We investigated the effect of arsenic trioxide (ATO) for inhibition of signal transducer and activator of transcription 3 (STAT3) and epithelial-mesenchymal transition (EMT) in gastric cancer cells, and the role of SH2 domain-containing phosphatase-1 (SHP-1) during this process.
10p
vibaku2711
22-07-2020
11
1
Download
-
The insulinoma associated protein tyrosine phosphatase 2 (IA-2) is one of the immunodominant autoantigens involved in the autoimmune attack to the beta-cell in Type 1 Diabetes Mellitus.
19p
vihamax2711
21-04-2020
11
0
Download
-
Inhibitors of protein tyrosine phosphatase 1B (PTP1B) are promising agents for the treatment of type 2 diabetes and obesity. From the alcoholic extract of the aerial parts of Selaginella tamariscina, four compounds including selaginellin (1), amentoflavone (2), βsitosterol (3), and scoparone (4) have been isolated and structurally elucidated by using combined chromatographic and spectroscopic experiments. Among the isolates, selaginellin (1) and amentoflavone (2), exhibited potential PTP1B inhibitory activities with IC50 values of 15.9 ± 0.6 and 7.4 ± 0.5 µM, respectively.
7p
cumeo3000
01-08-2018
24
1
Download
-
SHP-1, a protein-tyrosine phosphatase with two srchomology 2 domains, is expressed predominantly in hematopoietic and epithelial cells and has been implicated in numerous signaling pathways as a negative regulator. Two promoters direct the expression of human and murine SHP-1, and two types of transcripts (I) and (II) SHP-1, are initiated from each of these promoters. The cDNA sequences of (I)SHP-1 and (II)SHP-1 are identical except in the 5¢ untranslated region and in the first few coding nucleotides.
8p
system191
01-06-2013
31
2
Download
-
The association of tubulin carboxypeptidase with micro-tubules may be involved in the determination of the tyrosi-nation state of the microtubules, i.e. their proportion of tyrosinated vs. nontyrosinated tubulin. We investigated the role of protein phosphatases in the association of carb-oxypeptidase with microtubules in COS cells. Okadaic acid and other PP1/PP2A inhibitors, when added to culture medium before isolation of the cytoskeletal fraction, pro-duced near depletion of the carboxypeptidase activity asso-ciated with microtubules. ...
9p
fptmusic
12-04-2013
51
2
Download
-
PTP-S2⁄TC45 is a nuclear protein tyrosine phosphatase that activates p53 and induces caspase 1-dependent apoptosis. We analyzed the role of ICE protease-activating factor (Ipaf), an activator of caspase 1 in p53-depend-ent apoptosis. We also determined the sequence of events that lead to apoptosis upon caspase 1 activation by Ipaf.
13p
dell39
27-03-2013
38
2
Download
-
Src homology 2 (SH2) domain-containing protein tyrosine phosphatase-1 (SHP-1) is a critical inhibitory regulator in T cell-receptor (TCR) signaling. However, the exact molecular mechanism underlying this is poorly defined, largely because the physiological substrates for SHP-1 in T cells remain elusive.
11p
inspiron33
26-03-2013
31
3
Download
-
The protein tyrosine phosphatase (PTP)-like phytase, PhyAsr, fromSeleno-monas ruminantiumis a novel member of the PTP superfamily, and the only described member that hydrolyzes myo-inositol-1,2,3,4,5,6-hexakisphosphate.
10p
galaxyss3
07-03-2013
38
3
Download
-
MINIREVIEW Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease Rafael Pulido1 and Rob Hooft van Huijsduijnen2 ´ ´ 1 Centro de Investigacion Prıncipe Felipe, Valencia, Spain 2 Merck Serono International, Geneva, Switzerland Keywords arthritis; asthma; cancer; laforin; multiple sclerosis; myoclonus epilepsy; myotubular myopathy; protein phosphorylation ⁄ dephosphorylation; PTEN; signal transduction Correspondence ´ ´ R.
19p
media19
05-03-2013
39
2
Download
-
We report the development of a high-level bacterial expression system for the Alzheimer’s disease-associated amyloid b-peptide (Ab), together with a scaleable and inexpensive purification procedure. Ab(1–40) and Ab(1–42) coding sequences together with added ATG codons were cloned directly into a Pet vector to facilitate production of Met-Ab(1–40) and Met-Ab(1– 42), referred to as Ab(L1–40) and Ab(L1–42), respectively.
11p
vinaphone15
27-02-2013
42
1
Download
-
Activation of the c-JUN N-terminal kinase (JNK) pathway is implicated in a number of important physiological processes, from embryonic morpho-genesis to cell survival and apoptosis. JNK stimulatory phosphatase 1 (JSP1) is a member of the dual-specificity phosphatase subfamily of protein tyrosine phosphatases.
11p
mobifone23
21-01-2013
46
2
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)