Underlying biology

Building on the success of the previous editions, the Textbook of drug design and discovery, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects.

451p vimeyers 29-05-2024 3 2   Download

Ebook "Ecological connectivity among tropical coastal ecosystems" provides a first-time comprehensive review of the major ecological interactions across tropical marine ecosystems that result from the mutual exchange of nutrients, organic matter, fish, and crustaceans. A group of leading authors from around the world reviews the patterns and underlying mechanisms of important biogeochemical and biological linkages among tropical coastal ecosystems in 15 chapters.

617p giangdongdinh 28-05-2024 5 1   Download

In this study, a simple technique combining conventional electrospinning and facile gas–solid reaction for fabricating PAN/Ag2S nanofibers was presented and tested. The obtained fibers would have excellent properties such as the flexibility of PAN nanofibers and efficient photocatalysis of the Ag2S nanoshells under visible light. The photocatalytic elimination of RhB in water was used to evaluate the activity and application of the synthesized material under visible light irradiation.

11p dianmotminh02 03-05-2024 4 2   Download

The article discusses the prospects for the introduction of the Russian accounting practice of International financial reporting standards (IFRS), the calculation of the fair value of the biological asset of horse breeding organizations under IFRS. A number of methods of calculation of fair value, a technique based on market value and calculation based on the method of profit capitalization and money flow discounting are considered to justify the effectiveness of supply chain management.

9p longtimenosee10 26-04-2024 2 1   Download

Ebook "Uncertainty in biology: A computational modeling approach" wants to address four main issues related to the building and validation of computational models of biomedical processes: (1) Modeling establishment under uncertainty; (2) Model selection and parameter fitting; (3) Sensitivity analysis and model adaptation; (4) Model predictions under uncertainty in each of the abovementioned areas, the book discusses a number of key-techniques by means of a general theoretical description followed by one or more practical examples.

471p ladongphongthanh1008 22-04-2024 5 2   Download

Ebook "Alginates: Biology and applications" provides an overview of the state of art of alginate material properties, genetics and the molecular mechanisms underlying alginate biosynthesis as well as applications of tailor-made alginates in medicine, food and biotechnology. Topics treated are: material properties of alginates, alginate production: precursor biosynthesis, polymerization and secretion, bacterial system for alginate uptake and degradation, enzymatic alginate modification,...

269p tracanhphuonghoa1007 22-04-2024 2 2   Download

Ebook "Early life origins of health and disease" is a new book which presents and discusses the many factors that may have impact on normal development. In a concise and readable manner, the authors consider both the proven and suggestive evidence that the high prevalence of hypertension, diabetes, obesity and, in some populations, kidney disease, may not be all due to genetics or adult environment alone.

246p tracanhphuonghoa1007 22-04-2024 4 1   Download

Ebook "X-ray free electron lasers: A revolution in structural biology" aims to provide the readers with an overview of the new methods that have been recently developed as well as a prospective on new methods under development. It highlights the most important and novel Structural Discoveries made recently with XFELS, contextualized with a big-picture discussion of future developments.

486p tracanhphuonghoa1007 22-04-2024 5 3   Download

Spatial patterns of forest trees have been long recognized as evidences of underlying biological processes within forests. We used point pattern analysis methods and process-based models to detect the demography and dynamics of trees in a primary rainforest stand. A fully mapped 1-ha plot was investigated in the tropical rain forest of Cuc Phuong National Park. Trees were stem-mapped, diameter-measured at breast height and classified into species.

13p vilarry 01-04-2024 3 0   Download

Neurodevelopmental disorders (NDDs) such as autism spectrum disorder, intellectual disability, developmental disability, and epilepsy are characterized by abnormal brain development that may affect cognition, learning, behavior, and motor skills. High co-occurrence (comorbidity) of NDDs indicates a shared, underlying biological mechanism.

14p vibransone 28-03-2024 5 2   Download

Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes (T2D). However, the underlying biological mechanisms for many of these associations remain unknown. GWAS signals close to the glucokinase regulatory protein gene (GCKR) have been reported for lipid and glucose metabolism traits and the risk of T2D.

14p vioraclene 31-03-2024 3 2   Download

Expression quantitative trait loci (eQTL) analysis is a powerful method to detect correlations between gene expression and genomic variants and is widely used to interpret the biological mechanism underlying identified genome wide association studies (GWAS) risk loci.

15p vioraclene 31-03-2024 4 2   Download

Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. However, despite extensive clinical and genomic studies, the molecular basis of AD development and progression remains elusive.

21p vioraclene 31-03-2024 2 2   Download

Cancer researchers use cell lines, patient-derived xenografts, engineered mice, and tumoroids as models to investigate tumor biology and to identify therapies. The generalizability and power of a model derive from the fidelity with which it represents the tumor type under investigation; however, the extent to which this is true is often unclear.

27p vibransone 28-03-2024 2 2   Download

The interleukin (IL)-1 pathway is primarily associated with innate immunological defense and plays a major role in the induction and regulation of inflammation. Both common and rare genetic variation in this pathway underlies various inflammation-mediated diseases, but the role of rare variants relative to common variants in immune response variability in healthy individuals remains unclear.

17p vibransone 28-03-2024 3 2   Download

Ebook "Solid state NMR (Topics in Current chemistry, Volume 306)" have provided first-hand accounts of various important research topics in solid-state NMR. The applications of solid-state NMR are illustrated in the context of amyloid fibrils. The techniques highlighted are mainly taken from the literature of amyloid research. These two chapters together provide a complementary account for the current status of biological solid-state NMR under magicangle spinning conditions.

328p coduathanh1122 27-03-2024 6 1   Download

Ebook "Mesenchymal stem cells: Basics and clinical application I" provides readers with contents including: prospective isolation and characterization of human bone marrow-derived MSCs; urine as a source of stem cells; expansion of mesenchymal stem/stromal cells under xenogenic-free culture conditions; adipose-derived mesenchymal stem cells - biology and potential applications;...

198p coduathanh1122 27-03-2024 3 1   Download

Ebook "Novel synthetic chemistry of ureas and amides" investigates the chemistry and application of molecules containing urea and amide bonds. These bonds are some of the strongest known and are fundamental to biological processes. The author describes his discovery that sterically hindered ureas undergo solvolysis at room temperature under neutral conditions. This is a remarkable finding, since ureas are inert under these conditions and a general rule of chemistry is that hindered substrates are less reactive.

179p coduathanh1122 27-03-2024 3 1   Download

Ebook "Electron paramagnetic resonance: Elementary theory and practical applications (Second edition)" provides an introduction to the underlying theory, fundamentals, and applications of EPR spectroscopy, as well as new developments in the area. Knowledge of the topics presented will allow the reader to interpret of a wide range of EPR spectra, as well as help them to apply EPR techniques to problem solving in a wide range of areas: organic, inorganic, biological, and analytical chemistry; chemical physics, geophysics, and minerology.

687p coduathanh1122 27-03-2024 2 1   Download

Ebook "Structural interfaces and attachments in biology" describes the attachment of dissimilar materials from multiple perspectives. The text will simultaneously elucidate natural bimaterial attachments and outline engineering principles underlying successful attachments to the communities of tissue engineers and surgeons.

385p cotieubac1004 15-03-2024 2 0   Download