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Underlying genetic mechanisms
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Acute myeloid leukemia (AML), characterized by the abnormal accumulation of immature marrow cells in the bone marrow, is a malignant tumor of the blood system. Currently, the pathogenesis of AML is not yet clear. Therefore, this study aims to explore the mechanisms underlying the development of AML.
20p
vishanshan
27-06-2024
1
1
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Ebook "Evolutionary transitions to multicellular life: Principles and mechanisms" integrates our understanding of the factors and processes underlying the evolution of multicellularity by providing several complementary perspectives (both theoretical and experimental) and using examples from various lineages in which multicellularity evolved.
489p
ladongphongthanh1008
22-04-2024
5
2
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Ebook "Alginates: Biology and applications" provides an overview of the state of art of alginate material properties, genetics and the molecular mechanisms underlying alginate biosynthesis as well as applications of tailor-made alginates in medicine, food and biotechnology. Topics treated are: material properties of alginates, alginate production: precursor biosynthesis, polymerization and secretion, bacterial system for alginate uptake and degradation, enzymatic alginate modification,...
269p
tracanhphuonghoa1007
22-04-2024
2
2
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Ebook "Early life origins of health and disease" is a new book which presents and discusses the many factors that may have impact on normal development. In a concise and readable manner, the authors consider both the proven and suggestive evidence that the high prevalence of hypertension, diabetes, obesity and, in some populations, kidney disease, may not be all due to genetics or adult environment alone.
246p
tracanhphuonghoa1007
22-04-2024
4
1
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Neurodevelopmental disorders (NDDs) such as autism spectrum disorder, intellectual disability, developmental disability, and epilepsy are characterized by abnormal brain development that may affect cognition, learning, behavior, and motor skills. High co-occurrence (comorbidity) of NDDs indicates a shared, underlying biological mechanism.
14p
vibransone
28-03-2024
5
2
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The nature and underlying mechanisms of the observed increased vulnerability to posttraumatic stress disorder (PTSD) in women are unclear. Methods: We investigated the genetic overlap of PTSD with anthropometric traits and reproductive behaviors and functions in women.
10p
vioraclene
31-03-2024
6
2
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Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes (T2D). However, the underlying biological mechanisms for many of these associations remain unknown. GWAS signals close to the glucokinase regulatory protein gene (GCKR) have been reported for lipid and glucose metabolism traits and the risk of T2D.
14p
vioraclene
31-03-2024
3
2
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Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses
The interleukin (IL)-1 pathway is primarily associated with innate immunological defense and plays a major role in the induction and regulation of inflammation. Both common and rare genetic variation in this pathway underlies various inflammation-mediated diseases, but the role of rare variants relative to common variants in immune response variability in healthy individuals remains unclear.
17p
vibransone
28-03-2024
3
2
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Ebook "Centromeres and kinetochores: Discovering the molecular mechanisms underlying chromosome inheritance" presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms controlling the transmission of genetic material between cell divisions and from parent to offspring.
552p
lamquandat
28-12-2023
3
2
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Crucian carp is a popular ornamental strain in Asia with variants in body color. To further explore the genetic mechanisms underlying gray and red body color formation in crucian carp, the skin transcriptomes and partial DNA methylation sites were obtained from red crucian carp (RCC) and white crucian carp (WCC).
12p
vinarcissa
21-03-2023
3
1
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Researchers have been exploring the molecular mechanisms underlying the control of periodontal ligament stem cell (PDLSC) osteogenic differentiation. Recently, long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) were shown to function as competitive endogenous RNAs (ceRNAs) to regulate the effect of microRNAs (miRNAs) on their target genes during cell differentiation.
13p
vinarcissa
21-03-2023
2
1
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Understanding the molecular basis of insecticide resistance is key to improve the surveillance and monitoring of malaria vector populations under control. In the major malaria vector Anopheles funestus, little is currently known about the role of the knockdown resistance (kdr) mechanism.
11p
vinarcissa
21-03-2023
1
1
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The significant social and economic loss as a result of bovine tuberculosis (bTB) presents a continuous challenge to cattle industries in the UK and worldwide. However, host genetic variation in cattle susceptibility to bTB provides an opportunity to select for resistant animals and further understand the genetic mechanisms underlying disease dynamics.
10p
vinarcissa
21-03-2023
3
1
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Considerable natural variation for lifespan exists within human and animal populations. Genetically dissecting this variation can elucidate the pathways and genes involved in aging, and help uncover the genetic mechanisms underlying risk for age-related diseases.
13p
vinarcissa
21-03-2023
9
1
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The ability to eliminate a parental genome from a eukaryotic germ cell is a phenomenon observed mostly in hybrid organisms displaying an alternative propagation to sexual reproduction. For most taxa, the underlying cellular pathways and timing of the elimination process is only poorly understood.
9p
vinarcissa
21-03-2023
3
1
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Transgenic poplar (Populus × euramericana ‘Guariento’) plants harboring five exogenous, stress-related genes exhibit increased tolerance to multiple stresses including drought, salt, waterlogging, and insect feeding, but the complex mechanisms underlying stress tolerance in these plants have not been elucidated.
17p
vinarcissa
21-03-2023
2
1
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Plants with heterosis/hybrid vigor perform better than their parents in many traits. However, the biological mechanisms underlying heterosis remain unclear. The methylation patterns of the parents both partially and dynamically passed onto their hybrids, and F1 hybrids has a non-additive mathylation level. A multidimensional process is involved in the formation of heterosis.
17p
vinarcissa
21-03-2023
2
1
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Association studies using a single type of omics data have been successful in identifying diseaseassociated genetic markers, but the underlying mechanisms are unaddressed. To provide a possible explanation of how these genetic factors affect the disease phenotype, integration of multiple omics data is needed.
5p
vihagrid
30-01-2023
5
3
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The expression of genes involved in regulating adipogenesis and lipid metabolism may affect economically important fatness traits in pigs. Allele-specific expression (ASE) reflects imbalance between allelic transcript levels and can be used to identify underlying cis-regulatory elements.
9p
vihagrid
30-01-2023
6
3
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Genome-wide association studies (GWAS) have been successfully implemented in cattle research and breeding. However, moving from the associations to identify the causal variants and reveal underlying mechanisms have proven complicated.
12p
vihagrid
30-01-2023
6
3
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