Underlying pathology
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Endometrial cancer is a prevalent gynecologic malignancy found in postmenopausal women. However, in the last two decades, the incidence of early-stage has doubled in women under 40 years old. This study aimed to investigate the clinical and pathological characteristics and adjuvant therapeutic modalities of both young and not -young patients with early-stage endometrial cancer in China’s real world.
10p vishanshan 27-06-2024 2 1 Download
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In this article, we explore the fundamental characteristics and mechanisms underlying the self-healing properties of bone tissue. In certain instances of trauma or pathological conditions resulting in bone defects, the natural healing process may be insufficient.
7p vikoch 27-06-2024 2 1 Download
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Comprehensive mutational profiling data now available on all major cancers have led to proposals of novel molecular tumor classifications that modify or replace the established organ- and tissue-based tumor typing. The rationale behind such molecular reclassifications is that genetic alterations underlying cancer pathology predict response to therapy and may therefore offer a more precise view on cancer than histology.
17p vibransone 28-03-2024 4 2 Download
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Systemic sclerosis (SSc) is a multi-organ autoimmune disease characterized by skin fibrosis. Internal organ involvement is heterogeneous. It is unknown whether disease mechanisms are common across all involved affected tissues or if each manifestation has a distinct underlying pathology.
24p vioraclene 31-03-2024 6 2 Download
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Ebook "Human nucleotide expansion disorders" represents a comprehensive and up-to-date description of many of the better-studied disorders. The expert authors discuss molecular, clinical and pathological aspects of the diseases as well as our current understanding of their underlying mechanisms. Of special interest are ideas and initial results of the different therapeutic strategies that can be employed to overcome some of the disorders.
296p manmanthanhla0201 27-02-2024 5 2 Download
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Adult Intussusception is an uncommon diagnosis, with one to three cases occurring in a population of 1,000,000 per year, primarily due to underlying pathological lead points, of which 70% are malignant. Lipoma is the most common benign tumour, and primary adenocarcinoma is the most common malignant one.
5p vitiki 30-01-2024 3 2 Download
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Colposcopy is an important tool in diagnosing cervical cancer, and the International Federation of Cervical Pathology and Colposcopy (IFCPC) issued the latest version of the guidelines in 2011. This study aims to systematically assess the accuracy of colposcopy in predicting low-grade squamous intraepithelial lesions or worse (LSIL+) / high-grade squamous intraepithelial lesions or worse (HSIL+) under the 2011 IFCPC terminology.
16p vischultz 20-10-2023 1 1 Download
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To investigate underlying mechanism of JMJD2A in regulating cytoskeleton remodeling in castrationresistant prostate cancer (CRPC) resistant to docetaxel. Tissue samples from CRPC patients were collected, and the expression of JMJD2A, miR-34a and cytoskeleton remodeling-related proteins were evaluated by qPCR, western blot and immunohistochemistry, and pathological changes were observed by H&E staining.
13p visharma 20-10-2023 4 2 Download
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Elastofibroma dorsi is a rare benign tumor of soft tissue, typically under the lower angle of the scapula. Its specific location and distinctive clinical symptoms can provide enough information for diagnosis. Nevertheless, pathological confirmation by biopsy may be needed to rule out other malignancies.
5p vigamora 23-05-2023 2 2 Download
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Suburbs in Melbourne present to us a unique context with which a new approach towards urban form can be devised using the existing conditions and opportunities found with infrastructural developments. This thesis contains the investigations on the various 'pathologies' of the urban fabric specifically on the potential use of 'Spaces Left-Over After Planning' as by-product to infrastructural development in relation to the reinvigoration of Melbourne suburbs under the influence of current and future metropolitan growth pressures.
98p runthenight05 01-03-2023 6 2 Download
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Marek’s disease (MD) is caused by the oncogenic Marek’s disease virus (MDV), and is a highly contagious avian infection with a complex underlying pathology that involves lymphoproliferative neoplasm formation.
9p vigalileogalilei 28-02-2022 10 1 Download
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This study is focused on the measurement of trace elements (zinc, copper, cadmium, lead and selenium) in the saliva of pigs in order to study their levels on different porcine pathological conditions in the field. The experiment involved 15 pigs without clinical signs of disease and 42 diseased pigs (suffering from lameness, rectal prolapse, fatigue or growth rate retardation).
12p vigalileogalilei 28-02-2022 13 1 Download
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Prevotella histicola is a facultative oral pathogen that under certain conditions causes pathologies such as caries and periodontitis in humans. Prevotella spp. also colonize the oral cavity of horses and can cause disease, but P. histicola has not yet been identified.
13p vidarwin 22-02-2022 15 1 Download
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Organizing pneumonia (OP) can be diagnosed pathologically, and cryptogenic OP (COP) and secondary OP (SOP) have been classifed by cause and particular underlying context. Because it is clinically difficult to difer‑ entiate between COP and SOP, this study investigated characteristics that could distinguish between COP and SOP.
10p vimackenziebezos 29-11-2021 7 0 Download
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Cholesterol plays vital roles in human physiology; abnormal levels have deleterious pathological consequences. In cancer, elevated or reduced expression of cholesterol biosynthesis is associated with good or poor prognosis, but the underlying mechanisms are largely unknown.
12p vimahuateng 26-11-2021 7 1 Download
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Parkinson’s disease (PD) is a degenerative disease with early-stage pathology hypothesized to manifest in brainstem regions. Vocal deficits, including soft, monotone speech, result in significant clinical and quality of life issues and are present in 90% of PD patients; yet the underlying pathology mediating these significant voice deficits is unknown.
13p vijeeni2711 30-06-2021 7 1 Download
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MicroRNAs play an important role in many fundamental biological and pathological processes. Defining the microRNAs profile underlying the processes by beneficial and detrimental lifestyles, including caloric restriction (CR), exercise and high-fat diet (HF), is necessary for understanding both normal physiology and the pathogenesis of metabolic disease.
14p vilichoo2711 23-06-2021 12 1 Download
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The present study was conducted under the pot condition. Pot experiment was laid out in Completely Randomized Design (CRD) with three replications at research field of the Department of Plant Pathology, Sam Higginbottom University of Agriculture, Technology and Science, during the Rabi season of 2019-20.
9p trinhthamhodang11 27-04-2021 8 1 Download
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Src homology 2 containing protein tyrosine phosphatase (PTP) 2 (Shp2) is a typical tyrosine phosphatase interacting with receptor tyrosine kinase to regulate multiple signaling pathways in diverse pathological processes. Here, we will investigate the effect of Shp2 inhibition on pulmonary arterial hypertension (PAH) in a rat model and its potential cellular and molecular mechanisms underlying.
10p vimontana2711 05-04-2021 11 3 Download
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Many studies have investigated whether pleural cholesterol levels can aid in diagnosis of pleural exudates, and the results have varied considerably. To gain a more reliable answer to this question, we meta-analyzed the literature on using pleural cholesterol or the ratio of cholesterol in pleural fluid to cholesterol in serum (P/S cholesterol ratio) as diagnostic tests to help identify pleural exudates.
9p vimontana2711 05-04-2021 12 1 Download