Understanding epigenetic regulations

Ebook "Epigenetics in cardiac disease" describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field.

321p ladongphongthanh1008 22-04-2024 7 2   Download

Ebook "Epigenetics in plants of agronomic importance: Fundamentals and applications (Transcriptional regulation and chromatin remodelling in plants)" provides a detailed understanding of the epigenetic mechanisms involved in plants of agronomic importance. The information presented here is significant because it is expected to provide the knowledge needed to develop in the future treatments to manipulate and selectively activate/inhibit proteins and metabolic pathways to counter pathogens, to treat important diseases and to increase crop productivity.

158p manmanthanhla0201 26-02-2024 6 1   Download

(BQ) Ebook Brain, behavior and epigenetics: Part 2 presents the following content: Chapter 8: The Strategies of the Genes: Genomic Conflicts, Attachment Theory, and Development of the Social Brain; Chapter 9: Genomic Imprinting Effects on Brain and Behavior: Future Directions; Chapter 10: Epigenetic Influence of the Social Environment; Chapter 11: Toward an Understanding of the Dynamic Interdependence of Genes and Environment in the Regulation of Phenotype; Chapter 12: Histone Deacetylase Inhibitors: A Novel Therapeutic Approach for Cognitive Disorders; Chapter 13: Epigenetic Mechanisms of ...

175p runordie7 30-08-2022 7 2   Download

Functional characterization of the noncoding genome is essential for biological understanding of gene regulation and disease. Here, we introduce the computational framework PINES (Phenotype-Informed Noncoding Element Scoring), which predicts the functional impact of noncoding variants by integrating epigenetic annotations in a phenotype-dependent manner.

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Emerging single-cell epigenomic methods are being developed with the exciting potential to transform our knowledge of gene regulation. Here we review available techniques and future possibilities, arguing that the full potential of single-cell epigenetic studies will be realized through parallel profiling of genomic, transcriptional, and epigenetic information.

10p viaristotle 29-01-2022 4 0   Download

DNA methylation is a key epigenetic modification in human development and disease, yet there is limited understanding of its highly coordinated regulation. Here, we identify 818 genes that affect DNA methylation patterns in blood using large-scale population genomics data.

24p viarchimedes 26-01-2022 7 1   Download

Gene expression can be influenced by DNA methylation 1) distally, at regulatory elements such as enhancers, as well as 2) proximally, at promoters. Our current understanding of the influence of distal DNA methylation changes on gene expression patterns is incomplete. Here, we characterize genome-wide methylation and expression patterns for ~ 13 k genes to explore how DNA methylation interacts with gene expression, throughout the genome.

13p vibeauty 23-10-2021 12 1   Download

Development of the face and mouth is orchestrated by a large number of transcription factors, signaling pathways and epigenetic regulators. While we know many of these regulators, our understanding of how they interact with each other and implement changes in gene expression during orofacial development is still in its infancy. Therefore, this study focuses on uncovering potential cooperation between transcriptional regulators and one important signaling pathway, retinoic acid, during development of the midface.

23p vitzuyu2711 29-09-2021 17 1   Download

Recognition of the airway epithelium as a central mediator in the pathogenesis of asthma has necessitated greater understanding of the aberrant cellular mechanisms of the epithelium in asthma. The architecture of chromatin is integral to the regulation of gene expression and is determined by modifications to the surrounding histones and DNA.

11p vimaine2711 26-03-2021 13 2   Download

MicroRNAs (miRNAs) are small noncoding RNAs that act as post-transcriptional regulators of gene targets. Accurate quantification of miRNA expression using validated internal controls should aid in the understanding of their role in epigenetic modification of genome function.

10p viwyoming2711 16-12-2020 11 1   Download

The identification of DNA methyltransferases (Dnmt) expression patterns during development and their regulation is important to understand the epigenetic mechanisms that modulate larval plasticity in marine fish. In this study, dnmt1 and dnmt3 paralogs were identified in the flatfish Solea senegalensis and expression patterns in early developmental stages and juveniles were determined.

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Identification and analysis of recurrent combinatorial patterns of multiple chromatin modifications provide invaluable information for understanding epigenetic regulations.

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Oral tongue squamous cell carcinoma (OTSCC) is one of the most aggressive forms of head and neck/oral cancer (HNOC), and is a complex disease with extensive genetic and epigenetic defects, including microRNA deregulation. Identifying the deregulation of microRNA-mRNA regulatory modules (MRMs) is crucial for understanding the role of microRNA in OTSCC.

11p vimale2711 25-08-2020 11 1   Download

The success of social insects is governed by remarkable levels of phenotypic plasticity displayed by colony members which is mediated by epigenetic inheritance. Waddington originally defined epigenetics as the study of the mechanisms that led to the development of a particular phenotype from a given genotype. Social insects have been primary model systems used for understanding the importance of insect DNA methylation. Epigenetic states are initiated by some type of environmental stimulus.

12p angicungduoc5 12-06-2020 17 1   Download

Typically the processes are adapted from wood processing which benefit from the larger mill size (Paper I). However, concerns associated with the local availability of non-wood raw material force pulp mills to remain small and thus lead to the need for processes to be as simple as possible in order to be competitive unless very valuable by-products can also be extracted. The benefits of utilising agro-fibres are their generally lower lignin content compared with woods (Grant 1958, Hurter 1988).

25p loixinloi 08-05-2013 57 5   Download

Many organizations and individuals played a role in the preparation of this report, and although it is not possible to cite all of them, several deserve particular mention. O. B. Hemeng and Baffour Asafo-Adjei of the Crops Research Institute (CRI) embraced the proposal to carry out the study and offered the use of CRI staff and facilities. Nana Koranteng and Mark Mostovac of the Canadian International Development Agency (CIDA-Ghana) were instrumental in mobilizing financial support from CIDA.

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Graphic design is a creative process that combines art and technology to communicate ideas in print and electronic media. Graphic design often refers to both the process (designing) by which the visual communication is created and the products (designs) which are generated. Common uses of graphic design include identity (logos and branding), websites, publications (magazines, newspapers, and books), advertisements, and product packaging.

66p hoangphiyeah1tv 24-04-2013 71 7   Download

The demand and supply side of the housing markets have been diverging for a while now. New households’ formation indicates a need for new dwellings to the extent of some 233,000 per year 4 . There is already a substantial backlog in building homes for individual households. The need for new dwellings is clear. Supply, demand and the price mechanism do not seem to get the market moving in the desired direction. The main cause is that the supply is driven by demand, but demand is not driven by supply but by individual households’ income and home equity levels. The...

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The folding of eukaryotic DNA into the 30 nm fibre comprises the first level of transcriptionally dormant chromatin. Understanding its structure and the processes of its folding and unfolding is a prerequisite for under-standing the epigenetic regulation in cell differentiation.

11p galaxyss3 07-03-2013 32 3   Download

Mixed lineage leukemias (MLLs) are histone-methylating enzymes with critical roles in gene expression, epigenetics and cancer. Although MLLs are important gene regulators little is known about their own regulation. Herein, to understand the effects of toxic stress onMLLgene regulation, we treated human cells with a common food contaminant mycotoxin, deoxynivalenol (DON).

9p viettel02 22-02-2013 31 2   Download