Understanding in an interactive

The aim of Beacon is to develop the understanding of fundamental processes that lead to material homogenisation, as well as to improve capabilities for numerical modelling. In earlier assessments of bentonite EBS, the mechanical interaction between the installed bentonite components has been neglected and an “ideal” final state has generally been assumed.

8p christabelhuynh 29-05-2020 12 2   Download

In the course of trying to understand the pathogenesis of leishmaniasis in relation to extracellular matrix (ECM) elements, laminin, a major ECM protein, has been found to bind saturably and with high affinity to a 67-kDa cell surface protein of Leishmania donovani. This interaction involves a single class of binding sites, which are ionic in nature, conformation-dependent and possibly involves sulfhydryls. Binding activity was significantly enhanced by Zn2+, an effect possibly mediated through Cys-rich zinc finger-like sequences on laminin....

8p system191 01-06-2013 41 4   Download

The availability of extensive genomic information and content has spawned an era of high-throughput screening that is generating large sets of func-tional genomic data. In particular, the need to understand the biochemical wiring within a cell has introduced novel approaches to map the intricate networks of biological interactions arising from the interactions of proteins.

14p fptmusic 12-04-2013 29 2   Download

Defining how the agonist–receptor interaction differs from that of the antagonist–receptor and understanding the mechanisms of receptor activation are fundamental issues in cell signalling. The V1a vasopressin receptor (V1aR) is a member of a family of related G-protein coupled receptors that are activated by neurohypophysial peptide hormones, including vasopressin (AVP). It has recently been reported that anarginyl in the distalN-terminus of theV1a Riscritical for binding agonists but not antagonists....

8p fptmusic 12-04-2013 28 2   Download