Understanding options

Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding the time course of molecular changes responsible for the development of acquired resistance could enable optimization of patients’ treatment options.

22p vibransone 28-03-2024 3 2   Download

A comprehensive understanding of cancer has been furthered with technological improvements and decreasing costs of next-generation sequencing (NGS). However, the complexity of interpreting genomic data is hindering the implementation of high-throughput technologies in the clinical context: increasing evidence on gene–drug interactions complicates the task of assigning clinical significance to genomic variants.

15p vibransone 28-03-2024 2 2   Download

Limited treatment options are available for patients infected with multidrug (MDR)- or pan-drug (PDR)- resistant bacterial pathogens, resulting in infections that can persist for weeks or months. In order to better understand transmission and evolutionary dynamics of MDR Acinetobacter baumannii (Ab) during long-term infection, we analyzed genomes from a series of isolates from individual patients at isolate-specific, patient-specific, and population levels.

12p vioraclene 31-03-2024 2 2   Download

Ebook "Conservation agriculture" is a ready reference on conservation agriculture and reinforces the understanding for its utilization to develop environmentally sustainable and profitable food production systems. The book describes various elements of conservation agriculture; highlights the associated breeding and modeling efforts; analyses the experiences and challenges in conservation agriculture in different regions of the world; and proposes some pragmatic options and new areas of research in this very important area of agriculture.

662p manmanthanhla0201 26-02-2024 3 1   Download

Part 1 book "Dogs all-In-One for dummies" includes content: What are dogs and why do they behave that way; ready, set, stop: what you need to know before you choose a dog; considering all the options; looking for love in all the right places; helping your adopted dog make the homecoming transition; all the right stuff; understanding your new roommate’s view of the world; fido and the law,... and other contents.

332p muasambanhan04 07-01-2024 2 1   Download

Continued part 1, part 2 of ebook "Principles of corporate finance (12th edition)" provides readers with contents including: payout policy and capital structure; payout policy; financing and valuation; understanding options; valuing options; real options; debt financing; credit risk and the value of corporate debt; risk management; financial planning and working capital management; mergers, corporate control, and governance; governance and corporate control around the world part eleven;...

539p tuongnhuoclan 27-11-2023 3 3   Download

To understand the proportion of uHCC (unresectable hepatocellular carcinoma) patients who achieve successful conversion resection in a high-volume setting with state of the art treatment options.

14p visharma 20-10-2023 4 2   Download

Continued part 1, part 2 of ebook "Business risk management: Models and analysis" provides readers with contents including: Chapter 6 - Understanding risk behavior; Chapter 7 - Stochastic optimization; Chapter 8 - Robust optimization; Chapter 9 - Real options; Chapter 10 - Credit risk; Appendix A - Tutorial on probability theory; Appendix B - Answers to even-numbered exercises;...

204p hanlinhchi 28-08-2023 4 4   Download

Ebook "Financial reporting and analysis (6th edition)" to foster a “critical thinking” approach to learning the subject matter. Our approach develops students’ understanding of the environment in which financial reporting choices are made, what the options are, how accounting information is used for various types of decisions, and how to avoid misusing financial statement data.

1147p tichhythan 17-08-2023 6 5   Download

Understanding the relationship between genetic admixture and performances is crucial for the success of crossbreeding programs. Use of small sets of ancestry informative markers (AIMs) is a cost effective option to estimate the levels of admixture in situations where pedigree recording is difficult.

14p vinarcissa 21-03-2023 2 1   Download

This study aims to identify potential marketing solutions for promoting the consumption of safe Ban pork in the urban market. A total of 35 in-depth interviews were conducted with green food stores and consumers in Hanoi city, who have been consuming Ban pork, to understand constraints of buyers, potential marketing channels, and quality certification options for marketing Ban pork in the urban market. Results show that green food stores and consumers had major difficulties in Ban pork consumption due to high price and inability of distinguish pure and crossbred Ban pork.

7p vihennessey 26-09-2022 8 2   Download

Lecture Class #18: Employee stock options and valuation. After studying this section will help you understand: Employee stock options and valuation. Structure of management compensation contracts.

12p huangminghao_1902 27-02-2022 11 1   Download

Lecture Class #4: Using accounting earnings for valuation. After studying this section will help you understand: overview of dell abnormal earnings valuation, quickly discuss accounting and real options, overview of dell abnormal earnings valuation, quickly discuss accounting and real options.

26p huangminghao_1902 27-02-2022 16 1   Download

Lecture Class #5: Comparative analysis. After studying this section will help you understand: Teams, company choices & due diligence matches can be found on sloanspace; CF may miss growth options, options to expand, options to redirect. You may need to adjust projections for GAAP expense treatment of R&D, customer acquisition costs, selected L/T marketing, etc. All difficult

30p huangminghao_1902 27-02-2022 13 1   Download

Lecture Class #7: How companies cook the books. After studying this section will help you understand: provide hints guidance today and during tuesday’s class; e mail me and your due diligence counterparty part 1 of your team’s project report by noon on friday, march 7.

14p huangminghao_1902 27-02-2022 17 1   Download

Lecture Engineering Economy (8e): Chapter 18. After completing this section, you will understand knowledge about: explain sensitivity to parameter variation; use three estimates for sensitivity analysis; calculate expected value E(X); determine E(X) of cash flow series; use decision trees for staged decisions; understand real options for staged funding;...

19p bachkhinhdaluu 03-12-2021 12 1   Download

Lecture Management the new competitive landscape (6e) - Chapter 5: Strategic management. After completing this section, you will understand knowledge about: develop a workable strategic plan for an organization using SWOT analysis; identify a company’s current corporate strategies, and list its strategic options; develop a vision and mission statement; accurately identify a company’s “core competence.”; explain each of the strategic planning tools you think the CEO should use, and why; ...

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Diagnosing patellofemoral instability disorders correctly, weight-bearing MRI (WB-MRI) has become an option. Aiming for a best possible accuracy in displaying potentially underlying causes, the named MRI modalities were sporadically even investigated in different knee flexion angles. However, despite conformed MRI-outcomediferences between WB-MRI and non-WB-MRI, none of the described MRI modalities have so far established themselves. Mainly this is due to an unfeasibility in daily clinical routine in regard to time and economic aspects.

10p vimackenziebezos 30-11-2021 14 1   Download

Cervical cancer is a common malignancy of the female genital tract. Treatment options for cervical cancer patients diagnosed at FIGO (2009) stage IB2 and IIA2 remains controversial. We perform a Bayesian network meta-analysis to directly or indirectly compare various interventions for FIGO (2009) IB2 and IIA2 disease, in order to improve our understand of the optimal treatment strategy for these women.

13p vimahuateng 26-11-2021 7 1   Download

Lecture Brand management - Lecture 6: Integrating Marketing Communications to Build Brand Equity, after studying this section will help you understand: Changes in the new media environment; Marketing communication options; Criteria in developing an integrated marketing communication program.

32p caphesuadathemtac 09-11-2021 24 1   Download