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Understanding phenotypic
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Forensic anthropology builds upon the skills developed within physical anthropology which focus on human osteology. The aim is to allow the bones to "speak," to allow the deceased to tell a story about who they were, how they lived and how they died. Our ability to "listen" depends largely upon our willingness to understand the principles by which the body is formed, how and why humans may vary phenotypically, and how the body responds to the environment in which it lives and dies.
390p
vimeyers
29-05-2024
3
2
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Ebook "Regulation of gene expression in the tumor environment (Regulation of melanoma progression by the microenvironment: The roles of PAR-1 and PAF)" will discuss several different aspects on the cross talk within the tumor microenvironment components leading to the acquisition of the metastasis phenotype. It is our hope that these state-of-the-art studies will shed further light on our understanding of these complicated processes.
155p
ladongphongthanh1008
22-04-2024
3
2
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Ebook "Tight junctions" highlight the importance of understanding TJ physiology in order to develop effective strategies for the treatment of pathological conditions such as cancer and autoimmune diseases. The first chapter of this book describes the evolution of the transporting epithelium from primitive metazoans to mammalian epithelia. Then, Chapters 2, 3, 4, 5, 6 and 7 review the characteristics and functionality of difi^erent proteins of theTJ studied in cell culture models, natural epithelia, mutant mice and heritable human diseases.
235p
ladongphongthanh1008
22-04-2024
5
2
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Ebook "Evolutionary transitions to multicellular life: Principles and mechanisms" integrates our understanding of the factors and processes underlying the evolution of multicellularity by providing several complementary perspectives (both theoretical and experimental) and using examples from various lineages in which multicellularity evolved.
489p
ladongphongthanh1008
22-04-2024
5
2
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Large-scale genomic studies of within-host diversity in Staphylococcus aureus bacteraemia (SAB) are needed to understanding bacterial adaptation underlying persistence and thus refining the role of genomics in management of SAB.
17p
vibransone
28-03-2024
6
2
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The resurgence of immune therapies in cancer medicine has elicited a corresponding interest in understanding the basis of patient response or resistance to these treatments. One aspect of patient response clearly lies in the genomic alterations that are associated with cancer onset and progression, including those that contribute to genomic instability and the resulting creation of novel peptide sequences that may present as neoantigens.
12p
vibransone
28-03-2024
6
2
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To demonstrate the causative role of gut microbiome in human health and diseases, we first need to identify, via next-generation sequencing, potentially important functional members associated with specific health outcomes and disease phenotypes.
12p
vibransone
28-03-2024
2
2
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Drawing genotype-to-phenotype maps in tumors is of paramount importance for understanding tumor heterogeneity. Assignment of single cells to their tumor clones of origin can be approached by matching the genotypes of the clones to the mutations found in RNA sequencing of the cells.
16p
vibransone
28-03-2024
2
1
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With the increasing number of genomic sequencing studies, hundreds of genes have been implicated in neurodevelopmental disorders (NDDs). The rate of gene discovery far outpaces our understanding of genotype–phenotype correlations, with clinical characterization remaining a bottleneck for understanding NDDs.
26p
vibransone
28-03-2024
4
2
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Ebook "Protein misfolding, aggregation, and conformational diseases - Part B: Molecular mechanisms of conformational diseases" continues to fill the gap in protein review and protocal literature while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders.
557p
cotieubac1004
15-03-2024
0
0
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Mixed phenotype acute leukemia (MPAL), a rare subgroup of leukemia characterized by blast cells with myeloid and lymphoid lineage features, is difficult to diagnose and treat. A better characterization of MPAL is essential to understand the subtype heterogeneity and how it compares with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
25p
vicwell
29-02-2024
3
2
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In ebook "Ecology and the environment (The plant sciences series)" plant biology is considered from the perspective of plants and their surrounding environment, including both biotic and abiotic interactions. The intended audience is undergraduate students in the middle or final phases of their programs of study.
675p
manmanthanhla0201
26-02-2024
4
1
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Ebook "Human nucleotide expansion disorders" represents a comprehensive and up-to-date description of many of the better-studied disorders. The expert authors discuss molecular, clinical and pathological aspects of the diseases as well as our current understanding of their underlying mechanisms. Of special interest are ideas and initial results of the different therapeutic strategies that can be employed to overcome some of the disorders.
296p
manmanthanhla0201
27-02-2024
5
2
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Part 2 book "Nests, eggs, and incubation - New ideas about avian reproduction" includes content: Improvements in our understanding of behaviour during incubation, the energetic costs of incubation; influence of incubation temperature on off spring phenotype and fitness in birds; advances in techniques to study incubation; applications of incubation science to aviculture and conservation,... and other contents
154p
muasambanhan02
18-12-2023
6
2
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Despite recent advances in research, there are still critical lacunae in our basic understanding of the cause, pathogenesis, and natural history of many cancers, especially heterogeneity in patient response to drugs and mediators in the transition from malignant to invasive phenotypes.
24p
vioracle
29-09-2023
4
2
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Data integration methods that combine data from different molecular levels such as genome, epigenome, transcriptome, etc., have received a great deal of interest in the past few years. It has been demonstrated that the synergistic effects of different biological data types can boost learning capabilities and lead to a better understanding of the underlying interactions among molecular levels.
10p
visteverogers
24-06-2023
8
2
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Mappings between ontologies enable reuse and interoperability of biomedical knowledge. The Radiology Gamuts Ontology (RGO)—an ontology of 16 918 diseases, interventions, and imaging observations—provides a resource for differential diagnosis and automated textual report understanding in radiology.
6p
visteverogers
24-06-2023
4
2
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Electronic (e)-phenotype specification by noninformaticist investigators remains a challenge. Although validation of each patient returned by e-phenotype could ensure accuracy of cohort representation, this approach is not practical. Understanding the factors leading to successful e-phenotype specification may reveal generalizable strategies leading to better results.
9p
vighostrider
25-05-2023
7
3
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To answer these questions at a systems level, we conducted high-content profiling of Drosophila larval locomotor behaviors for over 100 genotypes. High content, quantitative phenotyping of larval locomotor behaviours provides a framework for system-level understanding of the gene networks underlying such behaviours.
11p
vinarcissa
21-03-2023
4
1
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Colour polymorphisms are common among animal species. When combined with genetic and ecological data, these polymorphisms can be excellent systems in which to understand adaptation and the molecular changes underlying phenotypic evolution.
16p
vinarcissa
21-03-2023
3
1
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