Unresolved problem

Medical digital twins are computational disease models for drug discovery and treatment. Unresolved problems include how to organize and prioritize between disease-associated changes in digital twins, on cellulomeand genome-wide scales. We present a dynamic framework that can be used to model such changes and thereby prioritize upstream regulators (URs) for biomarker- and drug discovery.

21p viellison 28-03-2024 5 2   Download

Ebook "Epstein barr virus: Methods and protocols" explores data from the applications of molecular biological methods and the applications of recent immunological and cytogenetic methods in Epstein-Barr Virus (EBV) that will offer readers possible new solutions to the unresolved problems in the EBV field. Chapters in this book cover topics such as: viral life cycle, latency, EBV-associated diseases and EBV diagnostics;...

273p lucchinguyen 28-12-2023 5 2   Download

Postoperative nausea and vomiting (PONV) as a clinically most common postoperative complication requires multimodal antiemetic medications targeting at a wide range of neurotransmitter pathways. Lacking of neurobiological mechanism makes this ‘big little problem’ still unresolved. We aim to investigate whether gut-vagus-brain reflex generally considered as one of four typical emetic neuronal pathways might be the primary mediator of PONV.

9p vidietmarhopp 28-12-2021 2 0   Download

This paper discuss current and emerging research on privacy and confidentiality concerns in data outsourcing and pinpoint potential issues that are still unresolved.

20p trinhthamhodang11 04-05-2021 20 5   Download

Fractures of the humeral shaft are associated with a profound temporary (and in the elderly sometimes even permanent) impairment of independence and quality of life. These fractures can be treated operatively or non-operatively, but the optimal tailored treatment is an unresolved problem.

9p viannito2711 20-04-2021 8 1   Download

Although the loss of bone mineral density (BMD) after total hip arthroplasty (THA) is a known problem, it remains unresolved. This study prospectively examined the effect of zoledronic acid (ZA) on bone turnover and BMD after cementless THA.

10p vitennessee2711 02-02-2021 10 1   Download

Distinguishing biologically relevant interfaces from lattice contacts in protein crystals is a fundamental problem in structural biology. Despite efforts towards the computational prediction of interface character, many issues are still unresolved.

16p viwyoming2711 16-12-2020 11 1   Download

The impact and consequences of cancer on the patients and their family caregivers (FCs) are closely intertwined. Caregivers’ burdens can be increased due to the patients’ unmet needs and unresolved problems. Additionally, the caregivers’ unmet needs may adversely affect their own well-being and the patients’ health outcomes.

15p vimale2711 21-08-2020 7 1   Download

The document History of the world from the 20th to the 21st century present the content: social change and national rivalry in Europe, beyond Europe the shifting balance of global power, the great war, revolution and the search for stability, post-war Europe, the united states and the beginning of the cold war, the transformation of Asia, the ending of European dominance in the Middle east, the cold war superpower confrontation, Latin America after 1945 problems unresolved, Africa after 1945 conflict and the threat of famine, the united states and the Soviet bloc after 1963 the great transf...

1008p cao_duy_son 15-08-2019 53 1   Download

Bài giảng Quản trị công - Chapter 4: Public management in flux (Reforms). Learning objectives of this chapter include: To be aware of the objectives of the first generation of public sector reforms, to be aware of the results of the first generation of public sector reforms, to be aware of unresolved problems of the first generation of public sector reforms, to understand differences in public sector reform trajectories of OECD governments, to be able to undertake a more systemic analysis of public sector reforms.

12p tangtuy02 08-03-2016 60 5   Download

We present a geometric view on bilingual lexicon extraction from comparable corpora, which allows to re-interpret the methods proposed so far and identify unresolved problems. This motivates three new methods that aim at solving these problems. Empirical evaluation shows the strengths and weaknesses of these methods, as well as a significant gain in the accuracy of extracted lexicons. and polysemy problems.

8p bunbo_1 17-04-2013 33 2   Download

This book focuses on the growing problems of governance in the United States and on potential means of alleviating them. The prob- lems are familiar: more single-issue politics and gridlock in Congress, more breakdowns in administrative control and accountability within the executive branch, and more litigation over public policy in the courts—as well as persistently low levels of public trust in the federal government since the 1960s. Relatively few Americans, however, have appreciated the potential of community-based initiatives to help re- solve some problems of governance.

318p huetay_1 28-02-2013 46 5   Download

Efforts to master the crisis have fallen short so far. Measures have been primarily implemented at a national level, if they have been implemented at all. As in many other countries, the bank rescue package in Germany has only been partially successful. The package’s provisions for the sale of toxic assets have hardly been taken advantage of to date.

39p enterroi 02-02-2013 51 3   Download

Although passive exposure to tobacco smoke has been linked to a number of health problems, it is unresolved whether it alters breast cancer risk. Most, but not all, studies that compared women who were passively exposed to tobacco smoke to women with no exposure to tobacco smoke reported an association of passive smoking with an increased risk of breast cancer. Only two of these studies showed a “dose- relationship”, where an increase in breast cancer risk was related to more tobacco smoke exposure.

4p taisaokhongthedung 09-01-2013 48 2   Download

Parallel and distributed computing has offered the opportunity of solving a wide range of computationally intensive problems by increasing the computing power of sequential computers. Although important improvements have been achieved in this field in the last 30 years, there are still many unresolved issues. These issues arise from several broad areas, such as the design of parallel systems and scalable interconnects, the efficient distribution of processing tasks, or the development of parallel algorithms....

298p bi_bi1 11-07-2012 80 7   Download