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Vaccine candidates
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Although HPV prophylactic vaccines can provide effective immune protection against high-risk HPV infection, studies have shown that the protective effect provided by them would decrease with the increased age of vaccination, and they are not recommended for those who are not in the appropriate age range for vaccination.
11p
vikoch
27-06-2024
1
1
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Ebook "Synthesis and vaccine evaluation of the tumor associated carbohydrate antigen RM2 from prostate cancer" focuses on the synthesis and vaccine evaluation of the prostate tumor- associated carbohydrate antigen RM2. The author first presents the use of the [1+2+3] one-pot sequential strategy to successfully synthesise the RM2 antigen and its analogues as single stereoisomers in every glycosylation step, producing good yields and stereoselectivity.
116p
tracanhphuonghoa1007
22-04-2024
5
3
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Shigella is a major diarrheal pathogen for which there is presently no vaccine. Whole genome sequencing provides the ability to predict and derive novel antigens for use as vaccines. Here, we aimed to identify novel immunogenic Shigella antigens that could serve as Shigella vaccine candidates, either alone, or when conjugated to Shigella O-antigen.
13p
vibransone
28-03-2024
3
2
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While effective vaccines are being administered globally, there is still a great need for antiviral therapies as antigenically novel SARS-CoV-2 variants continue to emerge across the globe. Viruses require host factors at every step in their life cycle, representing a rich pool of candidate targets for antiviral drug design.
18p
viellison
28-03-2024
1
1
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T-cells play a crucial role in the adaptive immune system by triggering responses against cancer cells and pathogens, while maintaining tolerance against self-antigens, which has sparked interest in the development of various T-cell-focused immunotherapies.
24p
vicwell
29-02-2024
2
1
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Ebook "Bacteriophage applications - Historical perspective and future potential" explores key applications of phage biotechnology and reviews recent advances in phage display technologies. The applications covered were selected on the basis of their significance and representativeness in the field. The small size and enormous diversity of bacteriophages make them ideal candidates for numerous applications across many industries.
88p
lamquandat
28-12-2023
6
2
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Part 2 book "Control of poultry mites" includes content: The testing of antibodies raised against poultry red mite antigens in an in vitro feeding assay; preliminary screen for vaccine candidates; endosymbiotic bacteria living inside the poultry red mite (Dermanyssus gallinae); molecular phylogenetic assessment of host range in five Dermanyssus species, monitoring of Dermanyssus gallinae in free-range poultry farms,...and other contents.
98p
oursky10
04-12-2023
3
2
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Part 2 book "Vaccine design, methods and protocols (Vol 1 - Vaccines for human diseases)" includes content: Assessment of live plague vaccine candidates, highly effective soluble and bacteriophage t4 nanoparticle plague vaccines against yersinia pestis, development of structure based vaccines for ehrlichiosis, dendritic cell based vaccine against fungal infection, flow cytometric analysis of protective T-cell response against pulmonary coccidioides infection,.... and other contents.
404p
oursky05
20-09-2023
1
0
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In this study, alkyl hydroperoxide reductase (AhpC) from M. bovis was evaluated as a new candidate vaccine antigen against TB in BALB/c mice model. The ahpC gene was amplified from M.bovis genome, cloned, and expressed in Escherichia coli. Vaccine antigen AhpC was formulated with Montanide ISA 61 VG, an oil-based emulsion adjuvant. Both IgG and IL-12 responses were observed in mice after administering the formulation both as a subunit vaccine alone and also as a booster vaccine for BCG immunization.
14p
lyhuyenthu
31-01-2023
6
2
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The development of an influenza vaccine for poultry that provides broadly protective immunity against influenza H5Nx viruses is a challenging goal. L. lactis/pNZ8149-HA1-M2 can serve as a promising vaccine candidate in poultry industry for providing protection against H5Nx virus infection in the field application.
12p
vidarwin
22-02-2022
12
1
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Bacterial ghosts are the evacuated bacterial cellular membranes from most of the genetic and pro‑ tein contents which preserved their surface characters. Recently, bacterial ghosts exploited for different biomedical applications, for instance, vaccination.
11p
vidarwin
22-02-2022
11
1
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The structural analysis also disclosed the similarities and differences between the models (Vtx1-1 and Vtx2). Furthermore, the thermal stability profile of plasmid-mediated nonO157 VTEC were studied. The molecular dynamics simulations of plasmid-mediated non-O157 VTEC structures (Vtx1-1 and Vtx2) illustrated the interactions between amino acids. On the other hand, Vtx1-1 and Vtx2 showed noticeable differences in their relative conformational flexibility and stability at elevated temperature.
7p
mudbound
10-12-2021
9
1
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Reverse vaccinology accelerates the discovery of potential vaccine candidates (PVCs) prior to experimental validation. Current programs typically use one bacterial proteome to identify PVCs through a filtering architecture using feature prediction programs or a machine learning approach.
21p
viansan2711
30-07-2021
9
1
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General objectives: Creating of attenuated mutant Vibrio parahaemolyticus strains causing immune response for fish to develop production of vaccines against nephrotic and hepatic necrosis disease for some marine fish.
27p
tunelove
10-06-2021
9
3
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Subunit vaccines based on recombinant proteins have been effective in preventing infectious diseases and are expected to meet the demands of future vaccine development. Computational approach, especially reverse vaccinology (RV) method has enormous potential for identification of protein vaccine candidates (PVCs) from a proteome.
11p
viwyoming2711
16-12-2020
13
0
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Malaria infection is still widespread in some parts of the world and threatens the lives of millions of people every year. Vaccines, especially oral vaccines are considered to be effective in reducing the burden of malaria morbidity and mortality.
15p
vioklahoma2711
19-11-2020
9
2
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With advances in reverse vaccinology approaches, a progressive improvement has been observed in the prediction of putative vaccine candidates. Reverse vaccinology has changed the way of discovery and provides a mean to propose target identification in reduced time and labour.
7p
vioklahoma2711
19-11-2020
8
1
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Computational scanning of peptide candidates that bind to a specific major histocompatibility complex (MHC) can speed up the peptide-based vaccine development process and therefore various methods are being actively developed.
9p
viconnecticut2711
29-10-2020
42
0
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A revolutionary diversion from classical vaccinology to reverse vaccinology approach has been observed in the last decade. The ever-increasing genomic and proteomic data has greatly facilitated the vaccine designing and development process.
10p
vicoachella2711
27-10-2020
21
1
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Canine parvovirus is the major cause of haemorrhagic gastroenteritis in canines worldwide. There is a high morbidity and mortality in the young puppies. The currently available CPV vaccine is protecting from all antigenic strains but still there is vaccination failure as the strains are emerging at higher rate.
6p
angicungduoc6
22-07-2020
7
1
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