Vaccine design
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Vaccines are powerful agents in infectious disease prevention but often designed to protect against some strains that are most likely to spread and cause diseases. Most vaccines do not succeed in eradicating the pathogen and thus allow the potential emergence of vaccine evading strains.
12p vibransone 28-03-2024 3 2 Download
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While effective vaccines are being administered globally, there is still a great need for antiviral therapies as antigenically novel SARS-CoV-2 variants continue to emerge across the globe. Viruses require host factors at every step in their life cycle, representing a rich pool of candidate targets for antiviral drug design.
18p viellison 28-03-2024 1 1 Download
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Part 1 book "Aquaculture - Farming aquatic animals and plants" includes content: Introduction, principles of aquaculture, aquaculture systems design, water quality, resource use and the environment, reproduction, life cycles and growth, genetics, nutrition and feeds, hatchery and larval foods, disease principles, pathogens and parasites, prevention of disease by vaccination, post‐harvest technology and processing
322p oursky09 08-11-2023 7 3 Download
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Part 2 book "Vaccine design, methods and protocols (Vol 2 - Vaccines for veterinary diseases)" includes content: Strategies for vaccine design using phage display derived peptides, laboratory scale production of recombinant HAA86 tick protein in pichia pastoris and in escherichia coli system; transient expression of viral proteins in plants using agrobacterium tumefaciens, recombinant botulinum toxoids - a practical guide for production,.... and other contents.
433p oursky05 20-09-2023 1 0 Download
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Part 1 book "Vaccine design, methods and protocols (Vol 1 - Vaccines for human diseases)" includes content: Clinical impact of vaccine development, future challenges for vaccinologists, principles of vaccination, proteomic monitoring of b-cell immunity, application of droplet digital PCR to validate rift valley fever vaccines, methods to evaluate novel hepatitis C virus vaccines, designing efficacious vesicular stomatitis virus vectored vaccines against ebola virus,.... and other contents.
491p oursky05 20-09-2023 0 0 Download
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Part 2 book "Vaccine design, methods and protocols (Vol 1 - Vaccines for human diseases)" includes content: Assessment of live plague vaccine candidates, highly effective soluble and bacteriophage t4 nanoparticle plague vaccines against yersinia pestis, development of structure based vaccines for ehrlichiosis, dendritic cell based vaccine against fungal infection, flow cytometric analysis of protective T-cell response against pulmonary coccidioides infection,.... and other contents.
404p oursky05 20-09-2023 1 0 Download
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Part 1 book "Vaccine design, methods and protocols (Vol 2 - Vaccines for veterinary diseases)" includes content: Challenges in veterinary vaccine development and immunization, development of mycoplasma hyopneumoniae recombinant vaccines, computational prediction of immunodominant epitopes on outer membrane protein (OPM) H of pasteurella multocida toward designing of a peptide vaccine; DNA vaccines against maedi–visna virus, detection of avian antigen specific T-cells induced by viral vaccines,.... and other contents.
445p oursky05 20-09-2023 0 0 Download
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Part 1 book "Vaccine technologies for veterinary viral diseases methods and protocols" includes content: Vaccines and vaccination for veterinary viral diseases - a general overview; using ic tagging methodology for production and purification of epitope loaded protein microspheres for vaccination, plant based vaccine antigen production, novel adjuvants and immunomodulators for veterinary vaccines,...and other contents.
149p oursky05 20-09-2023 0 0 Download
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Part 2 book "Vaccine technologies for veterinary viral diseases methods and protocols" includes content: Generation of recombinant modified vaccinia virus ankara encoding VP2, NS1, and VP7 proteins of bluetongue virus, generation of recombinant capripoxvirus vectors for vaccines and gene knockout function studies,...and other contents.
130p oursky05 20-09-2023 1 0 Download
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Part 2 book "Development and formulation of veterinary dosage forms" includes content: Formulation of vaccines, administration devices and techniques, specification development and stability assessment, bioavailability bioequivalence assessments, design of preclinical studies
206p oursky04 14-09-2023 7 2 Download
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To propose a novel modeling of aflatoxin immunization and surrogate toxin conjugate from AFB1 vaccines, an immunogen based on the mimotope, (i.e. a peptide-displayed phage that mimics aflatoxins epitope without toxin hazards) was designed.
10p vihermione 06-01-2023 6 3 Download
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Glaesserella parasuis, the causative agent of Glӓsser’s disease, is widespread in swine globally resulting in significant economic losses to the swine industry. Prevention of Glӓsser’s disease in pigs has been plagued with an inability to design broadly protective vaccines, as many bacterin based platforms generate serovar or strain specific immunity.
9p vigandhi 23-02-2022 11 1 Download
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This article reports the steps of an educational intervention, which is designed to change livestock breeders’ preventive behavior in terms of vaccinating their livestock against brucellosis. The study has been conducted in a rural area in a country with the second highest brucellosis prevalence in the world.
13p vidarwin 22-02-2022 10 1 Download
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Mutant peptides presented by MHC (major histocompatibility complex) Class II in cancer are important targets for cancer immunotherapy. Both animal studies and clinical trials in cancer patients showed that CD4 T cells specific to tumor-derived mutant peptides are essential for the efficacy of immune checkpoint blockade therapy by PD1 antibody.
9p vitzuyu2711 29-09-2021 10 1 Download
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CD4+ T-cell epitopes play a crucial role in eliciting vigorous protective immune responses during peptide (epitope)-based vaccination. The prediction of these epitopes focuses on the peptide binding process by MHC class II proteins. The ability to account for MHC class II polymorphism is critical for epitope-based vaccine design tools, as different allelic variants can have different peptide repertoires.
11p viwyoming2711 16-12-2020 20 1 Download
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Recent efforts in HIV-1 vaccine design have focused on immunogens that evoke potent neutralizing antibody responses to a broad spectrum of viruses circulating worldwide. However, the development of effective vaccines will depend on the identification and characterization of the neutralizing antibodies and their epitopes.
15p vikentucky2711 26-11-2020 13 1 Download
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Coronaviruses are the diverse group of RNA virus. From 1960, six strains of human coronaviruses have emerged that includes SARS-CoV and the recent infection by deadly MERS-CoV which is now going to cause another outbreak. Prevention of these viruses is urgent and a universal vaccine for all strain could be a promising solution in this circumstance. In this study we aimed to design an epitope based vaccine against all strain of human coronavirus.
10p vikentucky2711 26-11-2020 6 3 Download
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One of the major challenges in the field of vaccine design is identifying B-cell epitopes in continuously evolving viruses. Various tools have been developed to predict linear or conformational epitopes, each relying on different physicochemical properties and adopting distinct search strategies.
15p vikentucky2711 26-11-2020 16 1 Download
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T cell epitope prediction tools and associated vaccine design algorithms have accelerated the development of vaccines for humans. Predictive tools for swine and other food animals are not as well developed, primarily because the data required to develop the tools are lacking.
11p vikentucky2711 24-11-2020 9 3 Download
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Malaria infection is still widespread in some parts of the world and threatens the lives of millions of people every year. Vaccines, especially oral vaccines are considered to be effective in reducing the burden of malaria morbidity and mortality.
15p vioklahoma2711 19-11-2020 9 2 Download