Variations in the pharmacokinetic

Variability in drug efficacy and adverse effects are observed in clinical practice. While the extent of genetic variability in classic pharmacokinetic genes is rather well understood, the role of genetic variation in drug targets is typically less studied.

15p vioraclene 31-03-2024 5 1   Download

Efflux transporters like MDR1 and MRP2 may modulate the pharmacokinetics of about 50 % of all drugs. It is currently unknown how much of the variation in the activities of important drug membrane transporters like MDR1 or MRP2 is determined by genetic or by environmental factors. In this study we assessed the heritability of the pharmacokinetics of talinolol as a putative probe drug for MDR1 and possibly other membrane transporters.

12p vioraclene 31-03-2024 10 2   Download

Part 1 book "Rang and Dale's pharmacology" includes content: How drugs act, how drugs act, how drugs act, how drugs act, cell proliferation, apoptosis, repair and regeneration, cellular mechanisms, method and measurement in pharmacology, absorption and distribution of drugs, drug metabolism and elimination, pharmacokinetics, individual variation, pharmacogenomics and personalised medicine,... and other contents.

413p muasambanhan05 22-01-2024 4 2   Download

Part 1 book "The physiological basis of veterinary clinical pharmacology" includes content: The pharmacokinetic basis of species variations in drug disposition, the concept of bioavailability and applications to veterinary dosage forms, interpretation of changes in drug disposition and interspecies scaling.

149p oursky05 20-09-2023 2 1   Download

The variation of drug responses and target does among individuals is mostly determined by genes. With the development of pharmacogenetics and pharmacogenomics, the differences in drug response between different races seem to be mainly caused by the genetic diversity of pharmacodynamics and pharmacokinetics genes.

20p vihagrid 30-01-2023 8 3   Download

The genetic variation underlying atorvastatin (ATV) pharmacokinetics was evaluated in a Mexican population. Aims of this study were: 1) to reveal the frequency of 87 polymorphisms in 36 genes related to drug metabolism in healthy Mexican volunteers, 2) to evaluate the impact of these polymorphisms on ATV pharmacokinetics, 3) to classify the ATV metabolic phenotypes of healthy volunteers, and 4) to investigate a possible association between genotypes and metabolizer phenotypes.

13p vinaypyidaw2711 26-08-2020 6 1   Download

Patients with febrile neutropenia (FN) exhibit changes in extracellular fluid that may alter the plasma concentrations of beta-lactams and result in therapeutic failure or toxicity. We evaluated the pharmacokinetics of piperacillin/tazobactam in patients with hematological malignancies and FN after receiving chemotherapy at a primary public cancer center.

6p vienzym2711 03-04-2020 12 2   Download

Given its narrow therapeutic range, digoxin’s pharmacokinetic parameters in infants are difficult to predict due to variation in birth weight and gestational age, especially for critically ill newborns. There is limited evidence to support the safety and dosage requirements of digoxin, let alone to predict its concentrations in infants.

11p vivalletta2711 11-01-2020 15 1   Download

This study aimed to estimate PKparameters of imipenem and those potential covariates. Methods: Burn patients with body surface area injured >20% andimipenem indicationwere recruited. Two set of plasma samples (30 min post-dose and 1-2 hours before next dose)were obtainedat imipeneminitiation and before the end of imipenem use. ARC was defined if 8h-urinary creatinine clearance (8hClcr) was above 130 mL.min1173 m2.

13p thithizone4 31-07-2019 18 1   Download

Principles of Genetic Variation and Human Traits (See also Chaps. 62 and 64) Variants in the human genome resulting in variation in level of expression or function of molecules important for pharmacokinetics and pharmacodynamics are increasingly recognized. These may be mutations (very rare variants, often associated with disease) or polymorphisms, variants that are much more common in a population. Variants may occur at a single nucleotide [known as single nucleotide polymorphism (SNP)] or involve insertion or deletion of one or more nucleotides.

6p tubreakdance 26-11-2010 111 5   Download